CAS: 1025687-58-4; Sodium (6-((5-Fluoro-2-((3,4,5-Trimethoxyphenyl)Amino)Pyrimidin-4-yl)Amino)-2,2-Dimethyl-3-Oxo-2,3-Dihydro-4H-Pyrido[3,2-B][1,4]Oxazin-4-yl)Methyl Phosphate

专利信息

专利号:US-2025289827-A1
优先权日:2022-12-02
标 题:Morphic forms of a mutant braf degrader and methods of manufacture thereof
发明人：YU ROBERT T; HE MINSHENG; SCHNADERBECK MATTHEW J; KREGER BRIDGET; POLLOCK ROY MACFARLANE; JIANG SIYI; LI MEIQI; CHEN BOLU; LU JIANNAN
权利人:C4 THERAPEUTICS INC
摘要:Advantageous isolated morphic forms of (3R)-3-[6-[2-cyano-3-[[ethyl(methyl)sulfamoyl]amino]-6-fluorophenoxy]-4-oxoquinazolin-3-yl]-8-[2-[1-[3-(2,4-dioxo-1,3-diazinan-1-yl)-5-fluoro-1-methylindazol-6-yl]-4-hydroxypiperidin-4-yl]acetyl]-1-oxa-8-azaspiro[4.5]decane (Compound 1), which is a mutant BRAF degrader, and methods to prepare Compound 1 morphic forms for therapeutic applications are provided in the invention. The invention also provides improved methods for the synthesis of Compound 1, new pharmaceutical compositions comprising Compound 1, and new uses of Compound 1.

专利号:US-8299242-B2
优先权日:2009-07-02
标 题 :Synthesis of 2,4-pyrimidinediamines

专利号:US-8481724-B2
优先权日:2009-07-02
标题:Synthesis of 2,4-pyrimidinediamines

专利号:US-2013274499-A1
优先权日:2009-07-02
标题 :Synthesis of 2,4-Pyrimidinediamines

专利号:US-8691798-B2
优先权日:2009-07-02
标题 :Synthesis of 2,4-pyrimidinediamines
发明人：FEIFER ULFRIED
权利人:RIGEL PHARMACEUTICALS INC
摘要:Disclosed herein are methods for synthesizing 2,4-pyrimidinediamines as well as intermediates used therein.

专利号:US-2011003986-A1
优先权日:2009-07-02
标 题 :Synthesis of 2,4-Pyrimidinediamines