CAS: 124605-42-1; Methyl (2R,3S)-3-(Tert-Butoxycarbonylamino)-2-Hydroxy-3-Phenylpropionate

相似化合物

158830-39-8 131968-74-6 145514-62-1

上下游产品

tert-butyl dicarbonatedi-tert-butyl dicarbonate Methyl (2R,3S)-(+)-2-hydroxy-3-azido-3-phenyl-propionate (2R,3S)-3-phenylisoserine methyl ester methyl (2R,3S)-2-benzyloxy-3-tert-butoxycarbonylamino-3-phenylpropanoate(4S,5R)-2,2-Dimethyl-4-phenyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-methyl ester (2R,4S,5R)-2-(3,4-Dimethoxy-phenyl)-4-phenyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-methyl ester (2R,4S,5R)-2,4-Diphenyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-methyl ester (2S,4S,5R)-2-(4-Methoxy-phenyl)-4-phenyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-methyl ester

Methyl Cinnamate置于palladium On Activated Charcoal,四氧化锇 Sodium Azide,Dihydroquinidine 4-Chlorobenzoate,氢气,Potassium Carbonate,N-甲基吗啉氧化物,三乙胺体系中,用 甲醇,二氯甲烷,甲酸甲酯,水,乙酸乙酯,N,N-二甲基甲酰胺,丙酮,甲苯 用作溶剂,化学反应 190.0H,反应生成(2R,3S)-N-叔丁氧羰基-3-苯基异丝氨酸甲酯
参考文献:An Improved Synthesis Of The Taxol Side Chain And Of Rp 56976
标题:An Improved Synthesis Of The Taxol Side Chain And Of Rp 56976
摘要:
Doi:10.1021/jo00293A052

专利信息

专利号:US-8987504-B2
优先权日:2010-06-18
标题 :Aminohydroxylation of alkenes
发明人：MEE SIMON PETER HAROLD; LUXENBURGER ANDREAS; HARRIS LAWRENCE DANIEL
权利人:MEE SIMON PETER HAROLD; LUXENBURGER ANDREAS; HARRIS LAWRENCE DANIEL; VICTORIA LINK LTD
摘要:The invention relates to a process for the aminohydroxylation of alkenes using N-oxycarbamate reagents, e.g. N-acyloxycarbamate, N-alkyloxycarbonyloxycarbamate and N-aralkoxycarbonyloxycarbamate reagents. The invention particularly relates to an intermolecular aminohydroxylation reaction that can be carried out in the absence of added base. The invention also relates to novel N-oxycarbamate reagents that are stable crystalline materials. The process of the invention is useful in the synthesis of compounds having a vicinal amino alcohol moiety, such as biologically active compounds.