CAS: 20173-04-0; N-Methyl-1-(Pyridin-3-yl)Methanamine

相似化合物

102297-41-6 63361-56-8 3000-75-7

上下游产品

CAS号16273-54-4 (E)-n-(吡啶-3-基亚甲基)甲胺 | CAS号500-22-1 吡啶-3-甲醛 | CAS号74-89-5 氨基甲烷 | CAS号3731-52-0 吡考胺 | CAS号102297-41-6 N-B°C-3-氨甲基吡啶 | CAS号100-54-9 3-氰基吡啶 | CAS号104936-47-2 Formamide, N-me... | CAS号56625-04-8 N-(pyridin-3-yl... | CAS号6959-48-4 3-氯甲基吡啶盐酸盐 | CAS号22083-74-5 (+/-)-尼古丁 | CAS号578-89-2 匹美酰胺

N-Boc-3-氨甲基吡啶置于盐酸,Sodium Hydride体系中,用 1,4-二氧六环 用作溶剂,化学反应 2.75H,反应生成N-甲基-N-(3-甲基吡啶)胺
参考文献:Hiv蛋白酶的基于对称性的抑制剂.酰化的2,4-二氨基-1,5-二苯基-3-羟基戊烷和2,5-二氨基-1,6-二苯基己烷-3,4-二醇的结构活性研究.
标题:Hiv蛋白酶的基于对称性的抑制剂.酰化的2,4-二氨基-1,5-二苯基-3-羟基戊烷和2,5-二氨基-1,6-二苯基己烷-3,4-二醇的结构活性研究.
摘要:描述了两种新的基于对称性的hiv蛋白酶抑制剂(负责人类免疫缺陷病毒成熟的酶)的构效关系.从铅化合物3-6开始,探讨了向对称或假对称抑制剂的一个或两个末端添加极性杂环末端基团的效果.水溶性增加> 1000倍,同时在体外保持对纯化的hiv-1蛋白酶的有效抑制和抗hiv活性.在大鼠中进行的药代动力学研究表明,单醇基和二醇基抑制剂的吸收特性存在显着差异.抑制剂19在大鼠中的口服生物利用度为19%;但是,体外获得的cmax未能超过抗hiv Ec50.在大鼠中口服给药后未获得实质性的二醇类有效抑制剂的血浆水平.然而,几种抑制剂的水溶性和体外抗病毒活性的最佳组合支持了它们在静脉治疗中的潜在用途.
Doi:10.1021/jm00055A003

专利信息

专利号:US-5424436-A
优先权日:1990-08-10
标题 :Processes for the synthesis of unsymmetrical secondary amines
发明人：GOE GERALD L; KEAY JAMES G; SCRIVEN ERIC F V; PRUNIER MICHAEL L; QUIMBY STEVEN J
权利人:REILLY IND INC
摘要:Imines are synthesized by the hydrogenation of pyridinecarbonitriles with amines in the presence of a rhodium-loaded catalyst. The resulting imines are stable and may be transiminated and then hydrogenated to form selected secondary amine products or may be hydrolyzed to aldehydes. n Further, a very useful class of unsymmetrical secondary amines represented by the formula RCH 2 NHAr (in which R is not aliphatic and Ar is aromatic and not attached to R), which has heretofore been accessible only with some difficulty, can be synthesized by processes herein disclosed utilizing the reductive intermolecular coupling of nitriles and primary aromatic amines.

专利号:EP-0548233-B1
优先权日:1990-08-10
标 题:Processes for the synthesis of imines, aldehydes, and unsymmetrical secondary amines
发明人：GOE GERALD; KEAY JAMES G; SCRIVEN ERIC F V; PRUNIER MICHAEL L; QUIMBY STEVEN J
权利人:REILLY IND INC
摘要:Imines are synthesized by the hydrogenation of pyridinecarbonitriles with amines in the presence of a rhodium-loaded catalyst. The resulting imines are stable and may be transiminated and then hydrogenated to form selected secondary amine products or may be hydrolyzed to aldehydes. Further, a very useful class of unsymmetrical secondary amines represented by the formula RCH2NHAr (in which R is not aliphatic and Ar is aromatic and not attached to R), which has heretofore been accessible only with some difficulty, can be synthesized by processes herein disclosed utilizing the reductive intermolecular coupling of nitriles and primary aromatic amines.

专利号:US-8981092-B2
优先权日:2008-09-19
标题 :Substituted 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-ones as modulators of protein kinase activity
发明人：MIRIZZI DANILO; CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; FERGUSON RON; CASUSCELLI FRANCESCO
权利人:MIRIZZI DANILO; CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; FERGUSON RON; CASUSCELLI FRANCESCO; NERVIANO MEDICAL SCIENCES SRL
摘要:Compounds which are 4,7-disubstituted derivatives of 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-one compounds, n nor pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

专利号:US-7468375-B2
优先权日:2004-04-26
标题:Inhibitors of the HIV integrase enzyme
发明人：DRESS KLAUS RUPRECHT; HU QIYUE; JOHNSON TED WILLIAM; PLEWE MICHAEL BRUNO; TANIS STEVEN PAUL; WANG HAI; YANG ANLE; YIN CHUNFENG; ZHANG JUNHU
权利人:PFIZER
摘要:The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIVâ€?) integrase enzyme.

专利号:US-4963572-A
优先权日:1987-08-12
标题:N-pyridyl methyl-N-'-cyanoisothiourea compounds useful in controlling insect pests
发明人：GSELL LAURENZ
权利人:CIBA GEIGY CORP
摘要:Novel substituted N-pyridylmethyl-N'-cyanoisothioureas of formula wherein R is C1-C4alkyl, cyclopropyl or benzyl; R1 is C1-C4alkyl or cyclopropyl; X is halogen; and n is the integer 0, 1, 2 or 3. Processes for the preparation of these compounds, the corresponding starting materials and intermediates and the use of the novel compounds in pest control, especially for controlling insects and representatives of the order Acarina, especially insect pests in rice crops, and as starting materials for the synthesis of novel pesticidal compositions are described.

专利号:EP-0548233-A1
优先权日:1990-08-10
标 题:METHODS OF SYNTHESIS OF IMINES, ALDEHYDES AND NON-SYMMETRIC SECONDARY AMINES.