CAS: 2102-59-2; (-)-Carveol

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(R)-Carvone aluminum isopropoxide isopropyl alcohol L-trans-pin°Carveol cis-(1R,5R)-5-isopropyl-2-methyl-2-cyclohexen-1-ol (1R-cis)-2-methyl-5-(1-methylethenyl)-2-cyclohexen-1-ol acetate trans carveol 3,5-dinitrobenzoate (-)-cis-carveol 3,5-dinitrobenzoate

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    专利号:US-10981850-B2
    优先权日:2019-04-15
    标 题 :One-step flow-mediated synthesis of cannabidiol (CBD) and derivatives
    发明人:PORCO JOHN A; BEELER AARON B; BROWN LAUREN E; TRILLES RICHARD V
    权利人:UNIV BOSTON
    摘要:Herein are described apparatus and processes for the preparation of cannabinoids, such as cannabidiol (CBD) and derivatives thereof. The apparatus and processes described can be used for the one-step, flow-mediated synthesis of cannabidiol and derivatives with improved overall yield, material throughput, and product purity relative to batch processes.

    专利号:US-12194020-B2
    优先权日:2017-12-22
    标 题:Reversing baldness through cannabinoid receptor activation
    发明人:POSTREL RICHARD
    权利人:POSTREL RICHARD
    摘要:This invention reverses male pattern baldness by shocking dormant hair follicles out of their androgen induced hibernation phase back to the active hair-growing anagenic phase. The invention integrates two functions: 1) It blocks synthesis of compounds holding the follicles in the telogenic/hibernating phase and 2) It stimulates synthesis of compounds animating the hair-growing/anagenic phase in the follicular activity cycle. One preferred embodiment comprises an enzyme inhibitor blocking the conversion of testosterone to dihydrotestosterone (DHT), a flavonoid simultaneously increasing synthesis of prostaglandins alternative to prostaglandin D2, and a selected cannabinoid compound stimulating restore the hair follicle to its normal growth cycle. This novel trimodal therapy restores the hair follicles to their normal cycling processes and maintains these restorative properties so long as this rebalance in maintained.

    专利号:WO-2020158831-A1
    优先权日:2019-01-30
    标 题:Transdermal absorption composition with controlled release of water-soluble hydrochloride
    发明人:ONO FUMIYASU; GOTO MASAHIRO
    权利人:UNIV KYUSHU NAT UNIV CORP; NISSAN CHEMICAL CORP
    摘要:The objective of the present invention is to provide a method for simply raising the transdermal absorption properties of a water-soluble hydrochloride without forming a prodrug by organic synthesis. The present invention relates to: a composition containing a water-soluble hydrochloride and a liposoluble compound having an aldehyde group; a transdermal absorption composition containing said composition, a transdermal absorption control agent, and a liposoluble medium; and a method for controlling the release of the water-soluble hydrochloride from the composition into the skin.

    专利号:US-5879690-A
    优先权日:1995-09-07
    标题:Topical administration of catecholamines and related compounds to subcutaneous muscle tissue using percutaneous penetration enhancers
    发明人:PERRICONE NICHOLAS V
    摘要:Compositions for the topical treatment of sagging subcutaneous muscle and overlying cutaneous tissue contain an active ingredient exhibiting or producing catecholamine activity such as catecholamines and/or related compounds in a dermatologically acceptable carrier that contains at least one percutaneous penetration enhancer. Examplary catecholamines include adrenaline, norepinepherine, dopamine and their precursors; catecholamine precursors such as tyrosine and phenylalanine are preferred. Many embodiments, particularly those employing tyrosine and/or phenylalanine as a catecholamine precursor, further contain a neurotransmitter synthesis enhancer such as dimethylaminoethanol, and other co-factors such as vitamin B 6 and pantothenic acid or calcium pantothenate are included in the composition to enhance the action of the active ingredients. Other compounds that scavenge free radicals and antioxidants may also be added.

    专利号:US-7211693-B2
    优先权日:2002-08-02
    标题:Preparation of lactic acid derivatives and their use
    发明人:SELIFONOV SERGEY
    权利人:AROMAGEN CORP
    摘要:The present invention relates to preparing lactic acid derivatives that are useful as odorants and monomers for polymer synthesis.

    专利号:WO-8911536-A1
    优先权日:1988-05-27
    标题:Microbial biocatalyst for production of terpenic aldehydes
    发明人:DAVIS KAREN JOHANNA; BEST DAVID JOHN; BURFIELD ANTHONY GRAHAM; TAYLOR FRANK; TALBOT JANE STELLA
    权利人:NOVALAL LTD
    摘要:An active biocatalyst for converting alpha-pinene epoxide to terpenic aldehydes useful in perfumery, e.g. formula (I), is produced by growing a microorganism, preferably Pseudomonas fluorescens NCIB 40043, to late log phase in a medium containing carbohydrate (e.g. glucose) as the carbon source, and adding alpha-pinene. The resulting culture comprises active biocatalyst which is brought into contact with alpha-pinene epoxide for aldehyde synthesis.
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    合成参考文献


    摘要:Ohmatsu, K.; Ooi, T., Science of Synthesis Knowledge Updates, (2011) 4, 122.
    摘要:Herter, S.; Turner, N. J., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 3, 107.
    参考文献:10.1124/dmd.30.5.602
    摘要:Miyazawa M, Shindo M, Shimada T. Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes. Drug Metab Dispos. 2002 May;30(5):602–7. doi: 10.1124/dmd.30.5.602.
    参考文献:10.1016/j.phytochem.2006.04.025
    摘要:Yadegarinia D, Gachkar L, Rezaei MB, Taghizadeh M, Astaneh SA, Rasooli I. Biochemical activities of Iranian Mentha piperita L. and Myrtus communis L. essential oils. Phytochemistry. 2006 Jun;67(12):1249–55. doi: 10.1016/j.phytochem.2006.04.025.
    参考文献:10.1111/j.1540-8159.2011.03128.x
    摘要:Li VH, Mallick A, Concannon C, Li VY. Wide complex tachycardia causing congestive heart failure. Pacing Clin Electrophysiol. 2011 Sep;34(9):1154–7. doi: 10.1111/j.1540-8159.2011.03128.x.
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