CAS: 23688-89-3; 6-Chloropyrazine-2-Carboxylic Acid

相似化合物

23611-75-8 6863-74-7 1240602-95-2

上下游产品

6-chloro-pyrazine-2-carboxylic acid methyl ester methyl pyrazine-2-carboxylate methylester of pyrazinecarboxylic acid 4-oxide 6-chloropyrazine-2-carboxylic acid chloride 6-chloro-N-(1H-tetrazol-5-yl)-2-pyrazinecarboxamide 6-chloropyrazine-2-carboxylic acid chloride (6-chloropyrazin-2-yl)carbamic acid tert-butyl ester

6-氯-2-吡嗪甲酸甲酯置于乙醇,Sodium Hydroxide,盐酸,水体系中,用 乙醇 用作溶剂,化学反应 2.0H,以94%的收率获得6-氯吡嗪-2-羧酸
参考文献:Selective Ligands For The Neuronal Nicotinic Receptors And Uses Thereof
标题:Selective Ligands For The Neuronal Nicotinic Receptors And Uses Thereof
摘要:本申请描述了公式(i)的选择性配体,用于神经元尼古丁受体(nnrs),更具体地用于α4β2 Nnr亚型,以及其组合物和使用方法,其中x,R1,X,R2,R3,L1,M,N,P和q在规范中有定义.

专利信息

专利号:US-9695191-B2
优先权日:2009-08-05
标题 :Conformationally constrained, fully synthetic macrocyclic compounds
发明人：OBRECHT DANIEL; ERMERT PHILIPP; OUMOUCH SAID; LACH FRANCK; LUTHER ANATOL; MARX KARSTEN; MÖHLE KERSTIN
权利人:OBRECHT DANIEL; ERMERT PHILIPP; OUMOUCH SAID; LACH FRANCK; LUTHER ANATOL; MARX KARSTEN; MÖHLE KERSTIN; POLYPHOR AG
摘要:Conformationally restricted, spatially defined 12-30 membered macrocyclic ring systems of type (I) are constituted by three distinct building blocks: an aromatic template a, a conformation modulator b and a spacer moiety c as detailed in the description and the claims. Macrocycles of type (I) are readily manufactured by parallel synthesis or combinatorial chemistry. They are designed to interact with specific biological targets. In particular, they show agonistic or antagonistic activity on the motilin receptor (MR receptor), on the serotonin receptor of subtype 5-HT 2B (5-HT 2B receptor), and on the prostaglandin F2•receptor (FP receptor). They are thus potentially useful for the treatment of hypomotility disorders of the gastrointestinal tract such as diabetic gastroparesis and constipation type irritable bowl syndrome; of CNS related diseases like migraine, schizophrenia, psychosis or depression; of ocular hypertension such as associated with glaucoma and preterm labour.

专利号:US-8518952-B2
优先权日:2008-08-06
标题 :6 substituted 2-heterocyclylamino pyrazine compounds as CHK-1 inhibitors
发明人：BRAGANZA JOHN FREDERICK; COLLINS MICHAEL RAYMOND; KATH JOHN CHARLES; NINKOVIC SACHA; LI HUI; RICHTER DANIEL TYLER
权利人:BRAGANZA JOHN FREDERICK; COLLINS MICHAEL RAYMOND; KATH JOHN CHARLES; NINKOVIC SACHA; LI HUI; RICHTER DANIEL TYLER; PFIZER
摘要:The present invention is directed to compounds of formula (I), n nand pharmaceutically acceptable salts thereof, their synthesis, and their use as CHK-1 inhibitors.