CAS: 349-95-1; (4-(Trifluoromethyl)Phenyl)Methanol

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CAS号455-24-3 4-三氟甲基苯甲酸 | CAS号2967-66-0 4-(三氟甲基)苯甲酸甲酯 | CAS号455-19-6 对三氟甲基苯甲醛 | CAS号583-02-8 4-(三氟甲基)苯甲酸乙酯 | CAS号64-17-5 乙醇 | CAS号329-15-7 对三氟甲基苯甲酰氯 | CAS号18282-51-4 4-碘苄醇 | CAS号289706-46-3 4-[2,2,2-三氟-1-[... | CAS号109-04-6 2-溴吡啶 | CAS号101466-85-7 3-(4-(三氟甲基)苯基)丙烯酸乙酯 | CAS号1053242-55-9 1,5-Bis[4-(trif... | CAS号32857-62-8 4-(三氟甲基)苯乙酸 | CAS号455-24-3 4-三氟甲基苯甲酸 | CAS号455-19-6 对三氟甲基苯甲醛 | CAS号455-18-5 对三氟甲基苯腈 | CAS号651735-47-6 [4-(trifluorome... | CAS号939-99-1 4-(三氟甲基)苄基氯 | CAS号402-49-3 4-三氟甲基苄溴

4-三氟甲基苯甲酸置于lithium Aluminium Tetrahydride,硫酸体系中,用 四氢呋喃 作为反应溶剂,化学反应 4.0H,反应生成 4-(三氟甲基)苄醇
参考文献:Synthesis And Selective Anticancer Activity Evaluation Of 2-Phenylacrylonitrile Derivatives As Tubulin Inhibitors
标题:Synthesis And Selective Anticancer Activity Evaluation Of 2-Phenylacrylonitrile Derivatives As Tubulin Inhibitors
摘要:研究目的 本研究旨在用 2-苯基丙烯腈合成 13 个系列的新型衍生物,评估它们在体内和体外的抗肿瘤活性. 与 2-苯基丙烯腈合成 13 个系列的新型衍生物,评估其体内和体外抗肿瘤活性,并获得新型微管蛋白抑制剂. 获得新型微管蛋白抑制剂. 研究方法 通过 Knoevenagel 缩合法合成了 13 个系列的 2-苯基丙烯腈衍生物,并在体内和体外评估了它们的抗肿瘤活性. 缩合合成了 13 个系列的 2-苯基丙烯腈衍生物,并用 Mtt 法测定了它们的抗增殖活性. 用流式细胞仪分析细胞周期和细胞凋亡.定量细胞迁移 用 24 孔 Boyden 室进行.蛋白质通过 用 Elisa 试剂盒检测微管组装的体外动力学. 试剂盒检测微管组装的体外动力学.分子对接由 Discovery Studio (Ds) 2017 客户端在线工具完成. 结果 在这些衍生物中,化合物 1G2A 对 Hct116 和 Bel-7402 具有很强的抑制活性. 对hct116(ic50 = 5.9 Nm)和bel-7402(ic50 = 7.8 Nm)细胞具有很强的抑制活性.化合物 1G2A 的选择性抗增殖活性和特异性均优于包括紫杉醇在内的所有阳性对照药物. 包括紫杉醇在内的所有阳性对照药物相比,化合物 1G2A 表现出更好的选择性抗增殖活性和特异性.化合物 1G2A 可抑制 Hct116 和 Bel-7402 细胞的增殖,使其停滞在细胞周期的 G2/m 期,抑制 Hct116 和 Bel-7402 细胞的迁移. 抑制 Hct116 和 Bel-7402 细胞的迁移以及细胞集落的形成.化合物 1G2A 对 Hct116 和 Bel-7402 细胞表现出卓越的微管蛋白聚合抑制活性. Bel-7402 细胞表现出优异的小管蛋白聚合抑制活性.分子对接分析结果表明,1G2A 可抑制微管蛋白,从而发挥抗癌作用. 小管蛋白,从而发挥抗癌作用. 结论 化合物 1G2A 在体内和体外都显示出了突出的抗肿瘤活性,有望进一步开发成高效的抗肿瘤药物. 有可能被进一步开发成对正常组织毒性小的高效抗肿瘤药. 对正常组织毒性小的高效抗肿瘤药物.
DOI:10.2174/0109298673263854231009063053

专利信息

专利号:US-2012129939-A1
优先权日:2009-02-26
标题:Polyamine inhibitors for the treatment and prevention of parkinson's disease
发明人：SMALL SCOTT A; LEWANDOWSKI NICOLE; LANDRY DONALD W; DENG SHI-XIANG
权利人:SMALL SCOTT A; LEWANDOWSKI NICOLE; LANDRY DONALD W; DENG SHI-XIANG
摘要:Disclosed herein are methods for treating a disease involving α-synucleic aggregation using (1) a compound which reduces the amount of polyamines in an amount effective to reduce α-synucleic aggregation; (2) a compound which inhibits polyamine synthesis in an amount effective to reduce α-synucleic aggregation; or (3) a compound which inhibits α-synucleic aggregation in an amount effective to reduce α-synucleic aggregation. Also disclosed are methods for reducing the amount of α-synucleic aggregation in a brain cell using (1) a compound which reduces the amount of polyamines in an amount effective to reduce α-synucleic aggregation; (2) a compound which inhibits polyamine synthesis in an amount effective to reduce α-synucleic aggregation; or (3) a compound which inhibits α-synucleic aggregation in an amount effective to reduce α-synucleic aggregation. Disclosed herein are also compounds which can be used in the above described methods.

专利号:US-2014243404-A1
优先权日:2010-09-14
标题 :Unique halogen-induced cyclizations, reagents therefor, and compounds produced thereby
发明人：SNYDER SCOTT ALAN; TREITLER DANIEL S; BRUCKS ALEXANDRIA P; GOLLNER ANDREAS; CHIRIAC MARIA I; WRIGHT NATHAN E; PFLUEGER JASON J; BREAZZANO STEVEN P
权利人:SNYDER SCOTT ALAN; TREITLER DANIEL S; BRUCKS ALEXANDRIA P; GOLLNER ANDREAS; CHIRIAC MARIA I; WRIGHT NATHAN E; PFLUEGER JASON J; BREAZZANO STEVEN P; UNIV COLUMBIA
摘要:This disclosure is related to halonium compounds useful for cyclization of polyenes, alkenoic acids, and alkenyl alkyl ethers, and halogenation of aromatic compounds. The synthesis of such halonium compounds, compounds made using such halonium compounds, and synthesis of natural compounds, including decalins, using the halonium compounds is also disclosed. A representative halonium compound of the disclosure is:

专利号:US-2002049320-A1
优先权日:2000-04-27
标 题:6-amino-2,4-dioxo-3,4-dihydro-1,3,5-triazine derivatives and methods for the solid phase synthesis thereof
发明人：GOPALSAMY ARIAMALA; YANG HUI Y
权利人:AMERICAN CYANAMID CO
摘要:The present invention relates to substituted 6-amino-2,4-dioxo-3,4-dihydro-1,3,5-triazine compounds of formula (I) n n n having pharmacological activity, to solid phase synthesis methods for their preparation, to combinatorial libraries thereof, utilizing libraries of the compounds for drug discovery, and to pharmaceutical compositions thereof.

专利号:US-11858880-B2
优先权日:2017-06-16
标题 :Anti-fungals compounds targeting the synthesis of fungal sphingolipids

专利号:US-2022394973-A1
优先权日:2017-06-16
标 题:Anti-fungals compounds targeting the synthesis of fungal sphingolipids

专利号:US-2018141897-A1
优先权日:2014-12-08
标 题 :Anti-fungals targeting the synthesis of fungal shingolipids