专利号:US-12077484-B2 优先权日:2019-12-23 标 题 :Process for the synthesis of melphalan 发明人:ALLEGRINI PIETRO; BONETTI ANDREA; MOLINARI MARCO; GAMBINI ANDREA 权利人:INDENA SPA 摘要:The invention relates to a process for the preparation of Melphalan (4-[bis(2-chloroethyl)amino]-L-phenylalanine of formula (I)said process comprising the reaction of a 4-amino-L-phenylalanine protected at the carboxy and amino aminoacidic groups with an agent able to convert the aromatic amino group into a group of formula: —N(CH2CH2OS(O)nO−)2, wherein n is 1 or 2 followed by conversion of the —N(CH2CH2OS(O)nO−)2 group into a —N(CH2CH2Cl)2 group.The invention also provides novel intermediates useful for the preparation of Melphalan.
专利号:US-6277982-B1 优先权日:1999-08-20 标题:Alkylation of alcohols, amines, thiols and their derivatives by cyclic sulfate intermediates 发明人:FRASER ALLISTER S; MANOHARAN MUTHIAH; COOK PHILLIP DAN; JUNG MICHAEL E; KAWASAKI ANDREW M 权利人:ISIS PHARMACEUTICALS INC 摘要:Methods for the alkylation of alcohols, amines and thiols by the use of cyclic sulfates are disclosed. The alkylated sulfates formed are versatile intermediates which may be further elaborated by methods of the invention. In particular, methods for the alkylation of the 2′, 3′ or 5′-hydroxy position of nucleosides and nucleoside analogs with cyclic sulfates to form the 2′, 3′ or 5′-O-alkyl sulfate modified compounds are disclosed. Displacement of the 2′,3′ or 5′-O-sulfate with a nucleophile provides 2′, 3′ or 5′-O-modified nucleosides and nucleoside analogs useful for the synthesis of oligomeric compounds having improved hybridization affinity and nuclease resistance.
专利号:US-5053530-A 优先权日:1990-04-10 标 题 :Preparation of isethionic acid with organic acid 发明人:ROBERTS JOHN S; MARK HAROLD W 权利人:PHILLIPS PETROLEUM CO 摘要:Synthesis of isethionic acid comprising contacting an alkali metal isethionate and an organic acid.
专利号:US-2017373306-A1 优先权日:2016-06-22 标题:Carbon-metal/alloy composite material, synthesis method, and electrode including same 发明人:ADAMSON PAUL; KENDRICK EMMA 权利人:SHARP KK 摘要:A carbon-metal/alloy composite material includes a composition represented by (1-a)Sn 1-x M 1 x +aM 2 +cC, wherein: M 1 includes one or more transition metals, metals, or metalloids; M 2 includes one or more transition metals, metals, or metalloids; x is 0≦x≦1; a is 0≦a≦1; and c is 0 专利号:US-12221429-B2 优先权日:2022-11-01 标 题:Method for synthesizing 1,3,2-dioxathiolane 2,2-dioxide by in-situ catalytic oxidation 发明人:LIU QIKUI; ZHANG XIAOMENG 权利人:UNIV SHANDONG 摘要:Disclosed is a method for synthesizing 1,3,2-dioxathiolane 2,2-dioxide (DTD) by in-situ catalytic oxidation. A titanium silicon (TS)-1 molecular sieve is modified with a Pd salt and an Au salt to obtain an Au—Pd/TS-1 molecular sieve, which catalyzes oxygen and hydrogen to form hydrogen peroxide, and oxidizes glycol sulfite in situ in a reactor to synthesize DTD. An Au—Pd/TS-1 molecular sieve catalyst prepared by the present disclosure, which has two catalytic activities of catalytic synthesis of hydrogen peroxide and catalytic oxidation of sulfite, can significantly increase the reaction rate, enable the complete conversion of raw materials in a shorter residence time, and effectively inhibit the hydrolysis of products, and a high-purity DTD product can be obtained by washing and evaporatively crystallizing an organic phase.
专利号:US-10461368-B2 优先权日:2018-01-12 标 题 :Deuterated electrolyte solvents 发明人:POIRIER ERIC 权利人:FORD GLOBAL TECH LLC 摘要:The disclosure generally relates to rechargeable batteries, for example, lithium-ion batteries including electrolytes with deuterated solvents. The use of deuterated solvents in the synthesis of lithium-ion electrolytes in rechargeable cells or batteries increases the chemical stability of the cell or batteries by reducing the rate of hydrogen related reactions during decomposition or inhibiting some of these parasitic reactions.
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合成参考文献
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