CAS: 53199-31-8; Bis(Tri-Tert-Butylphosphine)Palladium

上下游产品

(0)bis(tri-ortho-tolylphosphine)palladium(0) tri-tert-butyl phosphine 3C6H4)3PC6H4(C4H9)PdCl)2((CH3C6H4)3PC6H4(C4H9)PdCl)23-(1-pyrrolidinyl)phenol tBu3PPd(Ph)BrtBu3PPd(Ph)Br [Pd(2-thienyl)(tri(tert-butyl)phosphine)(bis(3,5-bis(trifluoromethyl)phenyl)amide)]

三叔丁基膦置于sodium Tert-Butoxide,Dibutylamine体系中,用 甲苯 作为反应溶剂,化学反应生成 二(三叔丁基膦)钯
参考文献:表征,反应性和环金属三的潜在催化居中性-叔丁基膦乙酸钯复杂
标题:表征,反应性和环金属三的潜在催化居中性-叔丁基膦乙酸钯复杂
摘要:醋酸钯和三-叔丁基膦在经由ch活化的室温下反应叔丁基团,以形成新颖的钯(II)配合物[(p吨卜3)的pd(ch 2 C(ch 3)2 P T Bu 2)(oac)].该环金属化的配合物可以通过加热或氢还原为pd(p T Bu 3)2,但是耐醇盐碱和胺的还原.由于存在这种环金属化的配合物,因此可以从pd(oac)2和三碘甲烷原位反应生成催化活性的钯(0)物质.如该配合物的催化惰性所表明的,叔丁基膦减少了.此外,Datively结合三-叔丁基膦容易通过胺和碱性较弱的膦移位以形成一系列新颖环金属钯(II)络合物.
DOI:10.1021/om2006936

专利信息

专利号:US-11427530-B2
优先权日:2018-02-09
标 题 :Synthesis of 4-chlorokynurenines and intermediates
发明人：LEVIN DANIEL; LEEMING PETER; EISENREICH EMERICH; LIU XUEJUN KARL
权利人:VISTAGEN THERAPEUTICS INC
摘要:The invention relates to an overall enantio-specific synthesis of 4-chlorokynurenine compounds, in particular L-4-chlorokynurenine, with improved yields. Large-scale syntheses are disclosed. The invention also relates to novel intermediates in the synthesis of L-4-chlorokynurenine.

专利号:US-9994567-B2
优先权日:2015-05-22
标 题:Synthesis of heterocyclic compounds
发明人：IBRAHIM PRABHA N; LIN JACK; SPEVAK WAYNE; ZHANG JIAZHONG
权利人:PLEXXIKON INC
摘要:Provided herein are intermediates and processes useful for facile synthesis of compounds of formula (I): n nor a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein Q, P 1 and P 2 are as defined in this disclosure.

专利号:US-11059835-B2
优先权日:2014-08-15
标 题 :Synthesis of cephalosporin compounds
发明人：WALLER DAVID; GAZDA GREGORY; MINDEN ZACHARY; BARTON LISA; LEIGH CLIFTON
权利人:MERCK SHARP & DOHME
摘要:Provided herein is a method for the synthesis of cephalosporin antibiotic compounds comprising a palladium-catalyzed coupling reaction.

专利号:US-9695169-B2
优先权日:2012-05-31
标 题:Synthesis of heterocyclic compounds
发明人：IBRAHIM PRABHA N
权利人:PLEXXIKON INC
摘要:Provided herein are intermediates and processes useful for facile synthesis of biologically active molecules.

专利号:US-9422259-B2
优先权日:2011-01-18
标题:Synthetic transtaganolide and basiliolide products, derivatives thereof, and synthesis methods thereof
发明人：NELSON HOSEA; MURAKAMI KEI; VIRGIL SCOTT C; STOLTZ BRIAN M; GORDON JONATHAN R
权利人:CALIFORNIA INST OF TECHN
摘要:Compounds represented by Formula I are provided that include synthetic transtaganolide and basiliolide products. Derivatives of these compounds and methods of synthesis are also provided.

专利号:US-12275733-B2
优先权日:2016-11-07
标 题:Substituted pyrido[3,4-b]indoles for the treatment of cartilage disorders
发明人：GRETZKE DIRK; RITZELER OLAF; HEINELT UWE; WEHNER VOLKMAR; SCHMIDT FRIEDEMANN
权利人:SANOFI SA
摘要:The present invention relates to 8-aryl-substituted and 8-heteroaryl-substituted 9H-pyrido[3,4-b]indoles of the formula (I), in which A, E, G, R1 to R6 and R10 are as defined in the claims, which stimulate chondrogenesis and cartilage matrix synthesis and can be used in the treatment of cartilage disorders and conditions in which a regeneration of damaged cartilage is desired, for example joint diseases such as osteoarthritis. The invention furthermore relates to processes for the synthesis of the compounds of the formula (I), their use as pharmaceuticals, and pharmaceutical compositions comprising them.