合成目标产物 1-Methylimidazole 主要起始原料 Basionic(Tm) Ac 75
(文献来源)合成步骤主要原料 Basionic(Tm) Ac 75
1-甲基氯化咪唑鎓置于sodium Hydroxide体系中,用 水 作为反应溶剂,以95%的收率获得产物n-甲基咪唑 参考文献:Ionic Liquids,The Method For Preparing The Same And Method For Removing Acetylenes From Olefin Mixtures Using The Ionic Liquids 标题:Ionic Liquids,The Method For Preparing The Same And Method For Removing Acetylenes From Olefin Mixtures Using The Ionic Liquids 摘要:提供了一种含有醚基的离子液体,其中包括铜(I)化合物,以及制备该离子液体的方法和使用该离子液体通过吸收或萃取去除烯烃中包含的微量乙炔基碳氢化合物的方法.当使用所披露的溶液时,由于离子液体稳定了cux,防止了cu(I)氧化为cu(II).因此,乙炔化合物的选择性去除效率大大提高,同时保持了长时间的去除性能.此外,由于根据本公开的溶液可用作萃取剂和吸收剂,相关操作简单,设备成本可以降低.
专利信息
专利号:US-2025313590-A1 优先权日:2024-03-16 标题:Phosphoramidite morpholino monomers towards synthesis/convergent synthesis of PMO, TMO, their chimera oligos in 5 prime to 3 prime direction 发明人:SINHA SURAJIT; GHOSH ATANU; BANERJEE ARPAN 权利人:INDIAN ASS FOR THE CULTIVATION OF SCIENCE 摘要:The present invention relates to 5′-morpholino amidite monomers as 5′-CE/5′- t Bu phosphoramidite morpholino monomers (2) and process chemistry for the efficient synthesis of N-Trityl or monomethoxytrityl (MMTr)-protected 5′-morpholino amidite monomers and their use in the synthesis of phosphorodiamidate morpholino oligonucleotides (PMO), thiophosphoramidate morpholino oligonucleotides (TMO) and their chimeras which can be used for antisense technology or in general oligonucleotides related research.
专利号:US-12012427-B2 优先权日:2019-10-31 标 题 :Synthesis of Fmoc-protected morpholino monomers and their use in the synthesis of morpholino oligomer 发明人:SINHA SURAJIT; KUNDU JAYANTA; GHOSH UJJWAL 权利人:INDIAN ASS FOR THE CULTIVATION OF SCIENCE 摘要:Present invention relates to stable Fmoc protected Morpholino monomers and corresponding oligonucleotides (PMO) and efficient synthesis of the same involving chlorophosphoramidate and H-Phosphonate chemistry. Successful syntheses of the oligonucleotide with higher yield and lesser time have been accomplished employing solid phase synthesis and easy deprotection of Fmoc group with Piperidine.
专利号:US-6683189-B1 优先权日:1996-02-26 标 题 :Method for the synthesis of pyrrole and imidazole carboxamides on a solid support 发明人:DERVAN PETER B; BAIRD ELDON 权利人:CALIFORNIA INST OF TECHN 摘要:The present invention describes a novel method for the solid phase synthesis of polyamides containing imidazole and pyrrole carboxamides. The polyamides are prepared on a solid support from aromatic carboxylic acids and aromatic amines with high stepwise coupling yields (>99%), providing milligram quantities of highly pure polyamides. The present invention also describes the synthesis of analogs of the natural products Netropsin and Distamycin A, two antiviral antibiotics. The present invention also describes a novel method for the solid phase synthesis of imidazole and pyrrole carboxamide polyamide-oligonucleotide conjugates. This methodology will greatly increase both the complexity and quantity of minor-groove binding polyamides and minor-groove binding polyamide-oligonucleotide conjugates which can be synthesized and tested.
专利号:US-10995049-B2 优先权日:2019-07-19 标 题 :Total synthesis of prostaglandin J natural products and their intermediates 发明人:LI JIAMING; XU CHEN; AHMED TONIA S; GRUBBS ROBERT H; STOLTZ BRIAN M 权利人:CALIFORNIA INST OF TECHN 摘要:The present disclosure is directed to methods of preparing prostaglandin J natural products by stereoretentive metatheses reactions and intermediates used in the synthesis of these natural products, including the use of intermediates of Formula (I-A), where R 1 is defined in the specification
专利号:US-9755163-B2 优先权日:2010-04-30 标 题:Synthesis of four coordinated palladium complexes and their applications in light emitting devices thereof 发明人:LI JIAN; TURNER ERIC 权利人:ARIZONA BOARD OF REGENTS ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIV; ARIZONA BOARD OF REGENTS ACTING FOR OR ON BEHALF OF ARIZONA STATE UNIV 摘要:Synthesis of four coordinated palladium complexes and their applications in light emitting devices thereof.
专利号:WO-2024185734-A1 优先权日:2023-03-03 标 题:Polyphosphorylated nucleoside, phosphate-activated nucleotide used for synthesis of polyphosphorylated nucleoside and method for synthesis of same, and method for synthesis of polyphosphorylated nucleoside using phosphate-activated nucleotide 发明人:KATAOKA MASANORI; FUKUI CHIHARU; TSUJI YOHEI; FUJIMURA Kazuma 权利人:NATIAS INC 摘要:The present invention provides: a polyphosphorylated nucleoside which has a structure represented by formula (I) and can be efficiently produced by a short process and a simple operation with use of a less expensive material; a phosphate-activated nucleotide which is used for the synthesis of the polyphosphorylated nucleoside and a method for the synthesis of this phosphate-activated nucleotide; and a method for the synthesis of a polyphosphorylated nucleoside using a phosphate-activated nucleotide. In the formula, B represents a protected or unprotected, natural or artificial nucleoside base; R 1 , R 2 , R 4 and R 5 each represent H or an alkyl group or the like, and R 1 , R 2 , R 4 and R 5 may be the same as or different from each other; X and Y each represents H, OH, OCH 3 or the like; h represents an integer of 1 to 3; p, n, m and q each represent 0 or an integer, and p, n, m and q are in no particular order; and (p + n + m + q) is an integer of 0 to 5,000.
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合成参考文献
参考文献:10.1021/jf903998d 摘要:Zhang A, Lu F, Sun RC, Ralph J. Isolation of cellulolytic enzyme lignin from wood preswollen/dissolved in dimethyl sulfoxide/n-methylimidazole. J Agric Food Chem. 2010 Mar 24;58(6):3446–50. doi: 10.1021/jf903998d. 参考文献:10.1007/978-1-61779-188-8_17 摘要:Lan T, Kandimalla ER. Synthesis, purification, and characterization of oligoribonucleotides that act as agonists of TLR7 and/or TLR8. Methods Mol Biol. 2011;764():249–61. doi: 10.1007/978-1-61779-188-8_17. 参考文献:10.1007/978-1-61779-188-8_18 摘要:Putta MR, Yu D, Kandimalla ER. Synthesis, purification, and characterization of immune-modulatory oligodeoxynucleotides that act as agonists of Toll-like receptor 9. Methods Mol Biol. 2011;764():263–77. doi: 10.1007/978-1-61779-188-8_18. 参考文献:10.4061/2011/480570 摘要:Sugizaki K, Umemoto T, Okamoto A. On-chip DNA methylation analysis using osmium complexation. J Nucleic Acids. 2011;2011():480570.