CAS: 7223-50-9; N-Propargylphthalimide

上下游产品

CAS号106-96-7 溴代丙炔 | CAS号1074-82-4 邻苯二甲酰亚胺钾盐 | CAS号624-65-7 3-氯丙炔 | CAS号16156-58-4 甲磺酸-2-丙炔-1-醇 | CAS号107-19-7 丙炔醇 | CAS号119812-51-0 邻苯二甲酰亚胺-DBU盐 | CAS号22509-74-6 N-乙氧羰基邻苯二甲酰亚胺 | CAS号2450-71-7 炔丙胺 | CAS号3416-57-7 邻苯二甲酰亚胺基丙酮 | CAS号19446-30-1 2-[4-(az°Can-1-... | CAS号19446-29-8 2-[4-(azepan-1-... | CAS号2450-71-7 炔丙胺 | CAS号132456-42-9 3-hydroxy-2-pro... | CAS号5428-09-1 N-烯丙基邻苯二甲酰亚胺 | CAS号5323-50-2 N-丙基酞酰亚胺

在 Pyridinium Chlorochromate体系中,用 二氯甲烷 作为反应溶剂,化学反应 2.0H,以86%的收率获得产物n-丙炔基邻苯二甲酸胺
参考文献:一锅烯复分解/ Diels-Alder反应用于构建高度官能化的新型多环氮杂化合物
标题:一锅烯复分解/ Diels-Alder反应用于构建高度官能化的新型多环氮杂化合物
摘要:使用第一代grubbs催化剂通过酶复分解合成了各种三环服务.乙炔的复分解反应在ch 2 Cl 2的回流过程中顺利进行,催化剂负载量低(3.0 Mol%),三环产物6和16的收率高(72-89%).所得的1,3-二烯经diels-Alder法是多环结构的合适前体.烯炔产物与亲二烯体的一锅rcm / Diels-Alder反应平稳进行,得到多环化合物,为单个环加合物.diels-Alder加合物的结构通过1 H NMR光谱和x射线分析确定.环加合物是通过亲二烯体向二烯中的二烯形成的.内在模式.
DOI:10.1016/j.Tet.2007.11.001

专利信息

专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人：SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

专利号:US-2003082830-A1
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products

专利号:WO-0006525-A9
优先权日:1998-07-25
标题:Synthesis of combinatorial libraries of compounds reminiscent of natural products

专利号:WO-0006525-A2
优先权日:1998-07-25
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products

专利号:US-6448443-B1
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products

专利号:RU-2071962-C1
优先权日:1987-12-18
标题 :Method of synthesis of triazolo-[4,3-a]-[1,4]-diazepines