CAS: 1217366-74-9; 4-(4-Bromo-3-(1,3-Dioxolan-2-yl)Phenoxy)Benzonitrile

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1160182-44-4 173427-53-7 98015-07-7

上下游产品

4-溴-3-(1,3-二氧杂环戊烷-2-基)苯酚 4-Bromo-3-(1,3-Dioxolan-2-yl)Phenol 1160182-44-4
4-(4-溴-3-甲酰基苯氧基)苯甲腈 4-(4-Bromo-3-Formylphenoxy)Benzonitrile 906673-54-9

4-溴-3-(1,3-二氧杂环戊烷-2-基)苯酚,对氟苯腈置于potassium Carbonate体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应生成4-(4-溴-3-(1,3-二氧戊环-2-基)苯氧基)苯甲腈
参考文献:Discovery And Structure-activity Study Of A Novel Benzoxaborole Anti-Inflammatory Agent (An2728) For The Potential Topical Treatment Of Psoriasis And Atopic Dermatitis
标题:Discovery And Structure-activity Study Of A Novel Benzoxaborole Anti-Inflammatory Agent (An2728) For The Potential Topical Treatment Of Psoriasis And Atopic Dermatitis
摘要:A Series Of Phenoxy Benzoxaboroles Were Synthesized And Screened For Their Inhibitory Activity Against Pde4 And Cytokine Release. 5-(4-Cyanophenoxy)-2,3-Dihydro-1-Hydroxy-2,1-Benzoxaborole (An2728) Showed Potent Activity Both In Vitro And In Vivo. This Compound Is Now In Clinical Development For The Topical Treatment Of Psoriasis And Being Pursued For The Topical Treatment Of Atopic Dermatitis. (C) 2009 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmcl.2009.03.007