CAS: 159749-28-7; 1-(Tert-Butoxycarbonyl)Azetidine-2-Carboxylic Acid

相似化合物

374791-02-3 496918-44-6 496918-48-0

上下游产品

CAS号24424-99-5 二碳酸二叔丁酯 | CAS号2133-34-8 (|S|)-(-)-2-羧基环丁胺 | CAS号2517-04-6 氮杂环丁烷-2-羧酸 | CAS号255882-72-5 N-B°C-2-氮杂环丁基甲酸甲酯 | CAS号255882-72-5 N-B°C-2-氮杂环丁基甲酸甲酯

N-Boc-2-氮杂环丁基甲酸甲酯置于lithium Hydroxide Monohydrate体系中,用 1,4-二氧六环,水 用作溶剂,化学反应 2.5H,反应生成1-叔丁氧羰基-L-氮杂环丁烷-2-甲酸
参考文献: Sulphone Compounds For Use In The Treatment Of Obesity[fr] Composés Sulfonés Et Leurs Procédés De Fabrication Et D'Utilisation
标题: Sulphone Compounds For Use In The Treatment Of Obesity[fr] Composés Sulfonés Et Leurs Procédés De Fabrication Et D'Utilisation

专利信息

专利号:US-8772301-B2
优先权日:2009-12-18
标题 :Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
发明人：HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D
权利人:HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, neurodegenerative disorders, neuropsychiatric disorders, disorders of cognition, learning or memory, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds set forth herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

专利号:US-8329686-B2
优先权日:2006-08-29
标题:Isatin analogues and uses therefor
发明人：MACH ROBERT H; WELCH MICHAEL; CHU WENHUA; ROTHFUSS JUSTIN
权利人:MACH ROBERT H; WELCH MICHAEL; CHU WENHUA; ROTHFUSS JUSTIN; UNIV WASHINGTON
摘要:Novel isatin analogues, including isatin analogues comprising Michael Acceptors (IMAs) are disclosed. Further disclosed are methods of synthesis of the isatin analogues, and uses of the analogues, including inhibition of caspase-3 and caspase-7, and in vivo imaging of apoptosis by Positron emission tomography (PET) or Single Photon Emission Computed Tomography (SPECT).

专利号:US-7691843-B2
优先权日:2002-07-11
标 题 :N-hydroxyamide derivatives possessing antibacterial activity
发明人：RAJU BORE G; O'DOWD HARDWIN; GAO HONGWU; PATEL DINESH V; TRIAS JAOQUIM
权利人:PFIZER
摘要:Novel N-hydroxyamide derivatives are disclosed. These N-hydroxyamide derivatives inhibit UPD-3-O—(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase, an enzyme present in gram negative bacteria and are therefore useful as antimicrobials and antibiotics. Methods of synthesis and of use of the compounds are also disclosed.