CAS: 217806-26-3; Tert-Butyl Azetidin-3-Ylcarbamate Hydrochloride

相似化合物

91188-13-5 193269-78-2 454703-20-9

1-二苯甲基氮杂环丁烷-3-氨基甲酸叔丁酯置于盐酸,Palladium 10% On Activated Carbon,氢气体系中,用 甲醇,醋酸异丙酯 用作溶剂,10.0~40.0 °C,400.01 Kpa 条件下,反应 49.0H,反应生成3-Boc-氨基氮杂环丁烷盐酸盐
参考文献:Efficient Manufacturing Process For The Selective Estrogen Receptor Degrader Gdc-9545 (Giredestrant) Via A Crystallization-Driven Diastereoselective Pictet-spengler Condensation
标题:Efficient Manufacturing Process For The Selective Estrogen Receptor Degrader Gdc-9545 (Giredestrant) Via A Crystallization-Driven Diastereoselective Pictet-spengler Condensation
摘要:
Doi:10.1021/acs.Oprd.1C00263

专利信息

专利号:US-11780834-B2
优先权日:2018-06-21
标题:Solid forms of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3- yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol and processes for preparing fused tricyclic compounds comprising a substituted phenyl or pyridinyl moiety, including methods of their use
发明人：CHUNG CHEOL KEUN; XU JIE; IDING HANS; CLAGG KYLE; DALZIEL MICHAEL; FETTES ALEC; GOSSELIN FRANCIS; LIM NGIAP-KIE; MCCLORY ANDREW; ZHANG HAIMING; CHAKRAVARTY PAROMA; NAGAPUDI KARTHIK; ROBINSON SARAH
权利人:HOFFMANN LA ROCHE; GENENTECH INC
摘要:Provided herein are solid forms, salts, and formulations of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol, processes and synthesis thereof, and methods of their use in the treatment of cancer.

专利号:US-7737166-B2
优先权日:2005-08-17
标 题:Antifungal bicyclic hetero ring compounds
发明人：KAWAKAMI KATSUHIRO; KANAI KAZUO; HORIUCHI TAKAO; TAKESHITA HIROSHI; KOBAYASHI SYOZO; SUGIMOTO YUICHI; ACHIWA ISSEI; KUROYANAGI JUNICHI
权利人:DAIICHI SANKYO CO LTD
摘要:A 1,6-β-glucan synthetase inhibitor is provided, having potent growth inhibition and having excellent safety. A compound is provided, capable of expressing in a wide spectral range and specifically or selectively, an antifungal effect based on its functional mechanism of 1,6-β-glucan synthesis inhibition. Also provided is a drug, a salt or hydrate thereof, especially an antifungal that contains the compound. Concretely, provided is a compound of the following formula (I), its salt or hydrate, and a drug or antifungal containing, as the active ingredient, the compound, its salt or hydrate: