CAS: 3273-68-5; 4-(2-Oxo-2,3-Dihydro-1H-Benzo[d]Imidazol-1-yl)Butanoic Acid

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Sodium Salt Of N-Isopropenylbenzimidazolin-2-One,γ-丁内酯 反应生成1-苯并咪唑酮-4-丁酸
参考文献:Ayupova,A. T.;Xalikov,S. S.;Molchanov,L. V.;Kadyrov,Ch. Sh.,Ximiya Prirod. Soedin.,1983,N 6,776-778
标题:Ayupova,A. T.;Xalikov,S. S.;Molchanov,L. V.;Kadyrov,Ch. Sh.,Ximiya Prirod. Soedin.,1983,N 6,776-778

专利信息

专利号:US-8629134-B2
优先权日:2007-02-01
标题:Enantioselective synthesis of 6-amino-7-hydroxy-4,5,6,7-tetrahydro-imidazo[4,5,1-jk][1]-benzazepin-2[1H]-one and zilpaterol
发明人：ALMENA-PEREA JUAN JOSE; BRINK MONIKA; GEIBETA GERHARD; KADYROV RENAT; MEYER THORSTEN
权利人:ALMENA-PEREA JUAN JOSE; BRINK MONIKA; GEIBETA GERHARD; KADYROV RENAT; MEYER THORSTEN; INTERVET INT BV
摘要:This invention relates to a process for the hydrogenation of a ketooxime to selectively form an aminoalcohol stereoisomer, and, in particular, to a process for the hydrogenation of 4,5-dihydro-imidazo[4,5,1-jk][1]benzazepin-2,6,7[1H]-trione-6-oxime or a salt thereof to selectively form a stereoisomer of 6-amino-7-hydroxy-4,5,6,7-tetrahydro-imidazo[4,5,1-jk][1]-benzazepin-2[1H]-one or a salt thereof. This invention also relates to the use of the 6-amino-7-hydroxy-4,5,6,7-tetrahydro-imidazo[4,5,1-jk][1]-benzazepin-2[1H]-one hydrogenation product or a salt thereof to selectively make a stereoisomer of zilpaterol or a salt thereof, as well as the use of such a zilpaterol stereoisomer or salt in methods of treatment and medicaments for animals.

专利号:US-11214551-B2
优先权日:2018-04-27
标题 :One pot synthesis of 4-(1,2-dihydro-2-oxobenzo[d]imidazol-3-yl)butanoic acid, a key intermediate of zilpaterol
发明人：RAVI KUMAR KANNASANI; MALLIK YADAV KASA; SREENU MULU; BABU V V V
权利人:RA CHEM PHARMA LTD
摘要:The present invention relates to one pot process for the preparation of 4-(1,2-dihydro-2-oxobenzo[d]imidazol-3-yl)butanoic acid of Formula-I, which is a key intermediate and its use in the preparation of Zilpaterol, which comprises condensation of methyl-4-chloro butyrate with 1-(prop-1-en-2-yl)-1H-benzo[d]imidazol-2(3H)-one in presence of a base and suitable solvent to give corresponding ester derivative, further hydrolyzation and acidification in presence of inorganic solvent to obtain Formula-I.

专利号:BR-112020021893-A2
优先权日:2018-04-27
标题:synthesis of a single container of 4- (1,2-dihydro-2-oxobenzo [d] imidazol-3-yl) butanoic acid, a key intermediate of zilpaterol

专利号:MX-2020011336-A
优先权日:2018-04-27
标题:SINGLE VESSEL SYNTHESIS OF 4-(1,2-DIHYDRO-2-OXOBENZO [D]IMIDAZOL-3-IL)BUTANOIC ACID, A KEY INTERMEDIATE OF ZILPATEROL.

专利号:WO-2019207591-A1
优先权日:2018-04-27
标 题 :One pot synthesis of 4-(1,2-dihydro-2-oxobenzo[d]imidazol-3-yl)butanoic acid, a key intermediate of zilpaterol

专利号:US-2021238146-A1
优先权日:2018-04-27
标 题 :One pot synthesis of 4-(1,2-dihydro-2-oxobenzo[d]imidazol-3-yl)butanoic acid, a key intermediate of zilpaterol