专利号:US-2023097824-A1 优先权日:2020-05-08 标 题:Semi-synthesis and use of racemic hematoxylin 发明人:DURRANT EDWARD E; HEINDL DIETER; HUBER FLORIAN MAURITIUS ERASUMU; KLEIN ERIC; KOSMEDER II JEROME W; VOSS EDGAR 权利人:VENTANA MED SYST INC; ROCHE DIAGNOSTICS OPERATIONS INC 摘要:A racemic hematoxylin formulation is disclosed that includes one or both of a stabilizer compound and an antioxidant. The disclosed composition exhibits sufficient stability to be utilized in an automated staining process. Methods of using and making the stabilized composition also are disclosed.
专利号:US-10772990-B2 优先权日:2014-04-01 标题 :Tissue filler compositions and methods of use 发明人:NIKOLIS ANDREAS; HERBERT LISE 权利人:KLOX TECH INC 摘要:The present disclosure relates to methods for stimulating collagen synthesis, cosmetic enhancement of soft tissue and/or inhibiting or treating scarring comprising administering a composition to an area to be treated within a soft tissue, wherein the composition comprises a tissue filler medium and a fluorophore; and illuminating the area with light having a wavelength which can be absorbed by the fluorophore.
专利号:US-2003186237-A1 优先权日:2001-02-14 标题:Methods and compositions of amplifying RNA 发明人:GINSBERG STEPHEN D; CHE SHAOLI 权利人:BAYLOR COLLEGE MEDICINE 摘要:The present invention pertains to a method that will increase the efficiency of second strand cDNA synthesis through a mechanism of “terminal continuationâ€? before further RNA amplification by RNA transcription using, for example, a bacteriophage promoter. In a specific embodiment, a transcription promoter is attached to the 5′ region of cDNA through the same mechanism of “terminal continuationâ€?. Genetic signals are subsequently amplified in a linear manner through RNA transcription. In specific embodiments, the orientation of the transcribed RNA is either sense or antisense, depending on the desired downstream application. In other embodiments, the present invention pertains to methods for extraction and amplification of RNA, particularly mRNA, from histologically stained tissues and cells.
专利号:WO-2024097977-A1 优先权日:2022-11-04 标题:Silk nanoparticle synthesis: tuning size, dispersity, and surface chemistry for drug delivery 发明人:SHAIDANI SAWNAZ; FALCUCCI THOMAS; FOSTER OLIVIA; SAHOO JUGAL KISHORE; HASTURK ONUR; KAPLAN DAVID L; JACOBUS CHARLOTTE S 权利人:TUFTS COLLEGE 摘要:Methods disclosed herein relate to generating silk nanoparticles with a low polydispersity index (PDI). Methods include adding a silk solution dropwise into a volatile solvent that is miscible with water, thereby forming a precipitate-bearing solution and applying shear forces to the precipitate-bearing solution for a length of time sufficient to achieve evaporation of at least 95% of the volatile solvent, thereby producing a population of silk fibroin nanoparticles in water having a polydispersity index (PDI) of 0.35 or less, including but not limited to, a PDI of 0.330 or less, 0.325 or less, 0.315 or less, 0.310 or less, 0.30 or less, 0.275 or less, 0.250 or less, 0.225 or less, or 0.200 or less. Parameters related to silk fibroin molecular weight, silk fibroin concentration, shear force application, and temperature may all be modified to achieve silk nanoparticles of a particular size exhibiting particular PDIs.
专利号:WO-2021224361-A2 优先权日:2020-05-08 标题 :Semi-synthesis and use of racemic hematoxylin
专利号:EP-4147024-A2 优先权日:2020-05-08 标 题:Semi-synthesis and use of racemic hematoxylin
1: Goel A, Lasyal R. Iridium nanoparticles with high catalytic activity in degradation of acid red-26: an oxidative approach. Water Sci Technol. 2016 Dec;74(11):2551-2559. doi: 10.1016/j.chemosphere.2016.05.033. Epub 2016 May 27. doi: 10.1002/jat.3134. Epub 2015 Feb 27. Spanish.
合成参考文献
摘要:National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina. 摘要:S86 | TATTOOINK | Regulated Tattoo Ink Ingredients as per EU regulation 2020/2081 | A list of regulated ingredients for tattoo ink and permanent make up (https://ec.europa.eu/jrc/en/news/how-safe-are-our-tattoos-and-permanent-makeup), Appendix 13 added to Commission Regulation (EU) 2020/2081, 14 December 2020 amending Annex XVII of REACH (https://eur-lex.europa.eu/eli/reg/2020/2081/oj). Dataset DOI:10.5281/zenodo.5710243