CAS: 452-77-7; 3-Fluoro-4-Methylaniline

该化合物是一种有机化合物,属于芳香氨胺类的类,该物质具有氟原子和亚麻素苯环的甲基组,具体地分别位于3和4个位置.该物质一般没有色度,视其纯度和形态而具有黄色黄色液体或固体;氟原子的存在具有独特的化学特性,例如,在核分裂性替代反应中增加电子浓度和潜在的再活动.3-Fluoro-4-甲基碘在有机溶剂中溶解,并显示出水中的中等溶性.该物质用于各种应用,包括合成药物,农业化学品和染料.安全考虑十分重要,因为吸入或浸入这种物质可能会对健康造成危害,而且应当采用适当的处理程序来减少接触.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号1427-07-2 2-氟-4-硝基甲苯 | CAS号88-72-2 邻硝基甲苯 | CAS号372-19-0 3-氟苯胺 | CAS号593-53-3 氟甲烷 | CAS号452-75-5 2-氟-4-氯甲苯 | CAS号394-42-3 2-氟-4-甲氧基苯甲酸 | CAS号452-78-8 3-氟-4-甲基苯酚 | CAS号405-06-1 3-氟-4-甲基苯甲醚 | CAS号446-31-1 4-氨基-2-氟苯甲酸 | CAS号64359-35-9 3-氟-4-甲基苯硫酚 | CAS号102561-42-2 3-氟-4-甲基苯异氰酸酯 | CAS号202865-78-9 2-溴-5-氟-4-甲基苯胺 | CAS号885021-03-4 4-(溴甲基)-3-氟苯氨基甲酸叔丁酯 | CAS号458-10-6 N-(3-氟-4-甲基苯基)乙酰胺 | CAS号494789-04-7 tert-butyl N-(3...

合成工艺路线路线简述

  • 合成目标产物 3-Fluoro-4-Methylaniline 主要起始原料 2-Fluoro-4-Nitrotoluene
  • (文献来源)合成步骤主要原料 2-Fluoro-4-Nitrotoluene
甲基硝基苯置于aluminum Nickel体系中,用 乙醇 作为反应溶剂,化学反应生成 3-氟-4-甲基苯胺
参考文献:Us6020379
标题:Us6020379

海关参考信息

专利信息


专利号:US-2025179012-A1
优先权日:2022-03-04
标 题:Synthesis of sulfur(vi) compounds and reagents for same
发明人:LOPCHUK JUSTIN MATTHEW; SHULTZ ZACHARY
权利人:H LEE MOFFITT CANCER CT & RES
摘要:This disclosure provides reagents and processes for the synthesis of organic compounds, more particularly reagents and processes for the asymmetric synthesis of sulfur (VI) containing organic compounds.

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:WO-0053313-A2
优先权日:1999-03-09
标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries

专利号:US-5998595-A
优先权日:1996-11-05
标题:Azidohalogenobenzyl derivatives, sugar compounds and protection of hydroxy groups
发明人:KUSUMOTO SHOICHI; FUKASE KOICHI
权利人:WAKO PURE CHEM IND LTD
摘要:Azidohalogenobenzyl derivatives of the formula (I) ##STR1## wherein A is a halogen atom, B is a halogen atom or a hydrogen atom, and X is a group reactive with a hydroxy group, methods of protecting hydroxy group(s) using said derivatives, and sugar compounds wherein a hydrogen atom of at least one hydroxy group is substituted by an azidohalogenobenzyl group. According to the present invention, there are provided novel derivatives capable of introducing a group into a compound having hydroxy group(s), which group is useful as a stable hydroxy-protecting group even in solid phase synthesis for the purpose of the extension of sugar chain under continuous acidic conditions and of being removed under mild conditions; sugar compounds protected by using said derivatives; and methods of protecting hydroxy group(s) using said derivatives.

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-7002020-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
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合成参考文献


摘要:Schafer, E.W. 1972. The acute oral toxicity of 369 pesticidal, pharmaceutical and other chemicals to wild birds. Toxicology and Applied Pharmacology. 21:315-330.
摘要:Schafer, E. W., Jr., W. A. Bowles Jr., and J. Hurlbut. 1983. The acute oral toxicity and repellency and hazard potential of 998 chemicals to one or more species of wild and domestic birds. Archives of Environmental Contamination and Toxicology 12:355-382.
摘要:Schafer, E. W., Jr., and W. A. Bowles Jr. 1985. Acute oral toxicity and repellency of 933 chemicals to house and deer mice. Archives of Environmental Contamination and Toxicology 14:111-129.
摘要:Schafer, E. W., Jr., and W. A. Bowles Jr. 2004. Toxicity, Repellency of Phytotoxicity of 979 Chemicals to Birds, Mammals and Plants. Research Report No. 04-01. National Wildlife Research Center, Fort Collins, Colorado. 118 pp. https://www.aphis.usda.gov/ws/nwrc/chem-effects-db/U_schafer041_2004.pdf
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