(4-Chloro-Phenylsulfanyl)-Methanesulfonic Acid置于氯化亚砜体系中,化学反应生成 对氯苯氯甲基硫醚 参考文献:Barber Et Al.,Journal Of Applied Chemistry,1953,Vol. 3,P. 266,273 标题:Barber Et Al.,Journal Of Applied Chemistry,1953,Vol. 3,P. 266,273
专利号:US-2014309424-A1 优先权日:2011-06-30 标题:Direct synthesis of 18f-fluoromethoxy compounds for pet imaging and the provision of new precursors for direct radiosynthesis of protected derivatives of o-([18f] fluoromethyl) tyrosine 发明人:BRUMBY THOMAS; GRAHAM KEITH; KRUGER MARTIN 权利人:BRUMBY THOMAS; GRAHAM KEITH; KRUGER MARTIN; PIRAMAL IMAGING SA 摘要:The invention describes novel direct synthesis methods for converting a precursor into a PET-tracer with a 18 F-fluoromethoxy-group. The invention is also directed to novel and stable precursors for the direct radiosynthesis of protected derivatives of O—([ 18 F]Fluoromethyl)tyrosines.
专利号:JP-2014523890-A 优先权日:2011-06-30 标题:Novel precursors for the direct synthesis of 18F-fluoromethoxy compounds for PET imaging and the direct radioactive synthesis of protected derivatives of O-([18F] fluoromethyl) tyrosine
专利号:WO-2013001088-A1 优先权日:2011-06-30 标 题 :Direct synthesis of 18f-fluoromethoxy compounds for pet imaging and the provision of new precursors for direct radiosynthesis of protected derivatives of o-([18f]fluoromethyl) tyrosine
专利号:EP-2751087-A1 优先权日:2011-06-30 标题 :Direct synthesis of 18f-fluoromethoxy compounds for pet imaging and the provision of new precursors for direct radiosynthesis of protected derivatives of o-([18f]fluoromethyl)tyrosine
专利号:MX-2013015239-A 优先权日:2011-06-30 标题 :DIRECT SYNTHESIS OF COMPOUNDS 18F-FLUOROMETOXI FOR GENERATION OF PET IMAGES AND THE SUPPLY OF NEW PRECURSORS FOR DIRECT RADIOSYNTHESIS OF PROTECTED DERIVATIVES OF OR - ([18F] FLUOROMETILE) TYPOSINE.
专利号:CN-103857660-A 优先权日:2011-06-30 标 题:For PET imaging18Direct synthesis of F-fluoromethoxy compounds and use thereof in direct radiosynthesis of O- ([ 2 ]18F]Novel precursors of protected derivatives of fluoromethyl) tyrosine
[参考文献]: Dennis N Kevill, Et Al. Nucleophilic Participation In The Solvolyses Of (Arylthio)Methyl Chlorides And Derivatives: Application Of Simple And Extended Forms Of The Grunwald-Winstein Equations. Curr Org Chem. 2012 Jun 1;16(12):1502-1511.