CAS: 825-40-1; 1-(2-Bromo-4-Chlorophenyl)Ethanone

该化合物是带有分子式C8H6BRClO的卤化芳烃酮,该化合物是有机合成的多用途中间体,特别是在制药,农用化学品和特殊化学品的制作方面.其独特的溴和氯替代成分可增强回动性,从而能够在芳香环上的特定位置有选择地发挥功能.该氯酮混合物还允许进行诸如减少,核分裂生物添加或凝聚等转化.该化合物在标准条件下表现出高度的纯度和稳定性,适合精确的合成应用.其明确界定的结构和一贯性有助于其在需要受控的再活性和再选择性的研究和工业过程中发挥作用.

英文名称1-(2-Bromo-4-Chlorophenyl)Ethanone
中文名称2-溴-4-氯苯乙酮
IUPAC名称1-(2-bromo-4-chlorophenyl)ethan-1-one
其它别名1-(2 -溴-4-氯苯基)乙酮; 2-Bromo-P-Chloroacetophenone
CAS编号825-40-1
MFCD编号:MFCD02683063
EINECS号:672-231-0
分子式:C8H6BrClO
分子量:233.49
产品CID: 1815958
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: URBATMJMOGHOCE-UHFFFAOYSA-N
InChI=1S/C8H6BrClO/c1-5(11)7-3-2-6(10)4-8(7)9/h2-4H,1H3…
计算化学: 氢键受体数1.0氢键供体数0.0可旋转键数1.0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
严重眼刺激类别2A
警示词Warning(警告)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险品标志Xi
安全声明26-36/37/39
危险类别码36/37/38

欧盟法规

C&L通报

上下游产品

CAS号1777-56-6 1-(4-chlorophen... | CAS号133111-56-5 6-(4-CHLOROPHEN...

合成工艺路线路线简述

108-37-2 = 825-40-1
反应条件:1.1 Reagents: Aluminum Chloride Solvents: Carbon Disulfide
标题:Behavior Of Three Bromochlorobenzenes In Friedel-Crafts Acylation Reactions
作者:Cam-Van,N. T.; Et Al
参考文献:Tetrahedron 日期:1964 卷标:20(10) 页码:2195-9]

84459-33-6 = 825-40-1
反应条件:1.1 Solvents: Diethyl Ether; 3 H,-10 °C1.2 Reagents: Ammonium Chloride Solvents: Water2.1 Reagents: Silica,Pyridinium Chlorochromate Solvents: Dichloromethane; 2 H,Rt
标题:α-Oxocarboxylic Acids As Three-Carbon Insertion Units For Palladium-Catalyzed Decarboxylative Cascade Synthesis Of Diverse Fused Heteropolycycles
作者:Zhou,Liwei; Et Al
参考文献:Organic Letters 日期:2021 卷标:23(8) 页码:2878-2883]

84459-33-6 = 825-40-1
反应条件:1.1 Solvents: Tetrahydrofuran; 0 °C; 0 °C1.2 Reagents: Ammonium Chloride Solvents: Water2.1 Reagents: Silica,Pyridinium Chlorochromate Solvents: Dichloromethane; Rt
标题:The Intramolecular Reaction Of Acetophenone N-Tosylhydrazone And Vinyl: Bronsted Acid-Promoted Cationic Cyclization Toward Polysubstituted Indenes
作者:Wang,Zhixin; Et Al
参考文献:Chemical Communications (Cambridge 日期:2021 卷标:57(14) 页码:1810-1813]

1086601-87-7 = 825-40-1
反应条件:1.1 Reagents: Dess-Martin Periodinane Solvents: Dichloromethane; 45 Min,Rt
标题:Direct Synthesis Of 1-Naphthylamines Enabled By 6-Endo-Dig Cyclization Strategy Using Copper Catalysis
作者:Ma,Peng; Et Al
参考文献:Applied Organometallic Chemistry 日期:2022 卷标:36(6)]

1086601-87-7 = 825-40-1
反应条件:1.1 Reagents: Silica,Pyridinium Chlorochromate Solvents: Dichloromethane; Rt
标题:Asymmetric Synthesis And Application Of Chiral Spirosilabiindanes
作者:Chang,Xin; Et Al
参考文献:Angewandte Chemie 日期:2020 卷标:59(23) 页码:8937-8940]

1086601-87-7 = 825-40-1
反应条件:1.1 Reagents: Silica,Pyridinium Chlorochromate Solvents: Dichloromethane; 2 H,Rt
标题:α-Oxocarboxylic Acids As Three-Carbon Insertion Units For Palladium-Catalyzed Decarboxylative Cascade Synthesis Of Diverse Fused Heteropolycycles
作者:Zhou,Liwei; Et Al
参考文献:Organic Letters 日期:2021 卷标:23(8) 页码:2878-2883]

1345036-19-2 = 825-40-1
反应条件:1.1 Reagents: Oxygen Catalysts: Uranyl Acetate Solvents: Acetone; 1 Atm,Rt1.2 Solvents: Dichloromethane; Rt
标题:Stepwise Benzylic Oxygenation Via Uranyl-Photocatalysis
作者:Hu,Deqing; Et Al
参考文献:Green Chemistry 日期:2022 卷标:24(1) 页码:124-129]

936-08-3 = 825-40-1
反应条件:1.1 Solvents: Diethyl Ether; 0 °C; 0 °C -> Rt; Overnight,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Cooled
标题:Enantioselective Bromo-Oxycyclization Of Silanol
作者:Xia,Zilei; Et Al
参考文献:Organic Letters 日期:2016 卷标:18(1) 页码:80-83]

84459-33-6 = 825-40-1
反应条件:1.1 Solvents: Diethyl Ether; 0 °C; 6 H,0 °C1.2 Reagents: Ammonium Chloride Solvents: Water2.1 Reagents: Dess-Martin Periodinane Solvents: Dichloromethane; 45 Min,Rt
标题:Direct Synthesis Of 1-Naphthylamines Enabled By 6-Endo-Dig Cyclization Strategy Using Copper Catalysis
作者:Ma,Peng; Et Al
参考文献:Applied Organometallic Chemistry 日期:2022 卷标:36(6)

1-(2-Bromo-4-Chlorophenyl)Ethan-1-Ol置于silica Gel,Pyridinium Chlorochromate体系中,用二氯甲烷作为反应溶剂,以65%的收率获得产物2-溴-4-氯苯乙酮
参考文献:手性螺硅双茚满烃的不对称合成及应用.
标题:手性螺硅双茚满烃的不对称合成及应用.
摘要:本文首次报道了通过rh催化的不对称双氢硅化反应开发的一类手性螺硅双茚满骨架.enantiopure Spsiol(螺硅双茚满二醇)是一种用于制备各种手性配体和催化剂的新型手性结构单元,使用该方案可以轻松地以大于10克的规模制备.通过开发相应的单齿亚磷酰胺配体(spsiphos),初步证明了这种新型螺硅双茚满骨架在不对称催化中的潜力,该配体既可用于rh催化的加氢反应,又可用于pd催化的分子内碳胺化反应.
DOI:10.1002/anie.202002289

海关参考信息

2902600000-乙苯
2903919090-氯苯
2912110000-甲醛
2912120000-乙醛
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-8461184-B2
优先权日:2006-05-31
标题 :Sulphur containing pyrazole derivatives as selective cannabinoid CB1 receptor antagonists
发明人：LANGE JOSEPHUS H M; KRUSE CORNELIS G; VLIET VAN BERNARD J
权利人:LANGE JOSEPHUS H M; KRUSE CORNELIS G; VLIET VAN BERNARD J; SOLVAY PHARM BV
摘要:The present invention relates to sulphur containing pyrazole derivatives, and their S-oxidized active metabolites, as selective cannabinoid CB 1 receptor antagonists having a high CB 1 /CB 2 receptor subtype selectivity, to methods for the preparation of these compounds, to novel intermediates useful for the synthesis of these pyrazole derivatives, to pharmaceutical compositions comprising one or more of these pyrazole derivatives as active ingredients, as well as to the use of these pharmaceutical compositions for the treatment of psychiatric and neurological disorders. The compounds have the general formula (I) n nwherein the symbols have the meanings given in the specification.

专利号:WO-2007138050-A1
优先权日:2006-05-31
标题:Sulphur containing pyrazole derivatives as selective cannabinoid cb1 receptor antagonists
发明人：LANGE JOSEPHUS H M; KRUSE CORNELIS G; VAN VLIET BERNARD J
权利人:SOLVAY PHARM BV; LANGE JOSEPHUS H M; KRUSE CORNELIS G; VAN VLIET BERNARD J
摘要:The present invention relates to sulphur containing pyrazole derivatives, and their S-oxidized active metabolites, as selective cannabinoid CB1 receptor antagonists having a high CB1/CB2 receptor subtype selectivity, to methods for the preparation of these compounds, to novel intermediates useful for the synthesis of said pyrazole derivatives, to pharmaceutical compositions comprising one or more of these pyrazole derivatives as active ingredients, as well as to the use of these pharmaceutical compositions for the treatment of psychiatric and neurological disorders. The compounds have the general formula (I) wherein the symbols have the meanings given in the specification.

专利号:DD-204092-A1
优先权日:1982-03-30
标题:PROCESS FOR SYNTHESIS OF 2-ALKYLIMINO-3,4-DIALKYL-2.3-DIHYDRO-4H-1.3.4-THIADIAZINES

专利号:CN-113880786-A
优先权日:2021-10-16
标题 :Synthesis method and antioxidant application of camphene aldehyde thiazole hydrazone derivative

专利号:CN-113880786-B
优先权日:2021-10-16
标题 :Synthesis method and anti-oxidation application of camphene aldehyde thiazole hydrazone derivative