CAS: 98-97-5; Pyrazine-2-Carboxylic Acid

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98-97-5 5780-66-5 6924-68-1

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CAS号89-01-0 2,3-吡嗪二羧酸 | CAS号109-08-0 2-甲基吡嗪 | CAS号13925-00-3 2-乙基吡嗪 | CAS号98-96-4 吡嗪酰胺 | CAS号13961-37-0 2-乙基哌嗪 | CAS号13481-25-9 2,3-二氰基吡嗪 | CAS号6924-68-1 吡嗪-2-甲酸乙酯 | CAS号123-32-0 2,5-二甲基吡嗪 | CAS号34569-20-5 N-benzenesulfon... | CAS号107-21-1 乙二醇 | CAS号5780-66-5 2-吡嗪甲醛 | CAS号4604-72-2 吡嗪-2-硫代酰胺 | CAS号402958-96-7 (2S)-2-环己基-N-(2... | CAS号36070-79-8 6-氯-2-吡嗪羧酰胺 | CAS号402958-98-9 (1S,3AR,6AS)-(2... | CAS号402957-28-2 特拉匹伟 | CAS号5049-61-6 氨基吡嗪 | CAS号39204-47-2 2-氯甲基吡嗪 | CAS号191739-36-3 1,4-双((苄氧基)羰基)哌... | CAS号23688-89-3 6-氯吡嗪-2-羧酸

吡嗪酰胺置于水体系中,用 Aq. Phosphate Buffer 作为反应溶剂,化学反应 3.0H,反应生成 2-甲酸吡嗪
参考文献:红球菌全细胞酰胺酶对芳香族和杂环酰胺的生物转化.mtb5:生物催化表征和底物特异性
标题:红球菌全细胞酰胺酶对芳香族和杂环酰胺的生物转化.mtb5:生物催化表征和底物特异性
摘要:摘要 在这项研究中,酰胺酶在红球菌属全细胞中的酰胺水解酶活性.mtb5 已用于将芳香族,单杂环和二杂环酰胺生物转化为相应的羧酸.苯甲酸,烟酸和吡嗪酸是具有广泛工业应用的羧酸.发现该菌株的酰胺酶在自然界中是可诱导的.针对存在于 Mtb5 全细胞中的酰胺酶的生物催化条件针对苯甲酰胺进行了优化.该酶在 50 Mm 磷酸钾缓冲液 Ph 7.0 中表现出最佳活性.该酶的最适温度和底物浓度分别为 50 oc 和 50 Mm.该酶在 30oc 下可稳定超过 6 小时.它显示出针对不同酰胺的底物特异性,包括脂肪族,芳香族和杂环酰胺.在优化的反应条件下,酰胺酶能够分别在 100,160 和 120 分钟内将 50 Mm 苯甲酰胺,烟酰胺和吡嗪酰胺转化为相应的酸,每毫升反应混合物使用 5 Mg 干细胞质量 (Dcm).这些酰胺的各自转化百分比分别为 95.02%,98.00% 和 98.44%,由全细胞实现.
DOI:10.1080/10242422.2017.1282467

专利信息

专利号:US-7344863-B2
优先权日:1998-03-13
标题:Methods for producing polypeptides through enhanced synthesis of encoding nucleic acid molecules
发明人：LI WU-BO; JESSEE JOEL A; SCHUSTER DAVID; XIA JIULIN; GEBEYEHU GULILAT
权利人:INVITROGEN CORP
摘要:The present invention is directed to compositions and methods for enhancing synthesis of nucleic acid molecules, particularly GC-rich nucleic acid molecules. Specifically, the invention provides compositions comprising one or more nitrogen-containing organic compounds having a formula selected from the group consisting of formula I and formula II (or salts or derivatives thereof), preferably 4-methylmorpholine N-oxide or betaine (carboxymethyltrimethylammonium), and further comprising one or more compounds selected from the group consisting of proline and an N-alkylimidazole compound, and more preferably proline, 1-methylimidazole or 4-methylimidazole. The invention further relates to methods for enhanced, high-fidelity synthesis of nucleic acid molecules, including via amplification (particularly PCR), reverse transcription, and sequencing methods. The invention also relates to nucleic acid molecules synthesized by these methods, to fragments or derivatives thereof, and to vectors and host cells comprising such nucleic acid molecules, fragments, or derivatives. The invention also relates to kits for synthesizing, amplifying, reverse transcribing or sequencing nucleic acid molecules comprising one or more of the compositions of the invention.

专利号:US-5877278-A
优先权日:1992-09-24
标题:Synthesis of N-substituted oligomers
发明人：ZUCKERMANN RONALD N; GOFF DANE A; NG SIMON; SPEAR KERRY; SCOTT BARBARA O; SIGMUND AARON C; GOLDSMITH RICHARD A; MARLOWE CHARLES K; PEI YAZHONG; RICHTER LUTZ; SIMON REYNA
权利人:CHIRON CORP
摘要:A solid-phase method for the synthesis of N-substituted oligomers, such as poly (N-substituted glycines) (referred to herein as poly NSGs) is used to obtain oligomers, such as poly NSGs of potential therapeutic interest which poly NSGs can have a wide variety of side-chain substituents. Each N-substituted glycine monomer is assembled from two 'sub-monomers' directly on the solid support. Each cycle of monomer addition consists of two steps: (1) acylation of a secondary amine bound to the support with an acylating agent comprising a leaving group capable of nucleophilic displacement by -NH2, such as a haloacetic acid, and (2) introduction of the side-chain by nucleophilic displacement of the leaving group, such as halogen (as a solid support-bound alpha -haloacetamide) with a sufficient amount of a second sub-monomer comprising an -NH2 group, such as a primary amine, alkoxyamine, semicarbazide, acyl hydrazide, carbazate or the like. Repetition of the two step cycle of acylation and displacement gives the desired oligomers. The efficient synthesis of a wide variety of oligomeric NSGs using automated synthesis technology of the present method makes these oligomers attractive candidates for the generation and rapid screening of diverse peptidomimetic libraries. The oligomers of the invention, such as N-substituted glycines (i.e. poly NSGs) disclosed here provide a new class of peptide-like compounds not found in nature, but which are synthetically accessible and have been shown to possess significant biological activity and proteolytic stability. Combinatorial libraries of cyclic compounds are disclosed wherein the cyclic compounds are comprised of at least one ring structure derived from cyclization of a peptoid backbone. The diversity of product compounds is generated by the sequential addition of substituted submonomers. The combinatorial library includes 10 or more, preferably 100 or more, and more preferably 1,000 or more distinct and different compounds. The library includes each of the product compounds in retrievable and analyzable amounts and preferably includes at least one biologically active compound. Methods of synthesizing the combinatorial libraries and assay devices produced using the libraries are disclosed as is methodology for screening for and obtaining biologically active cyclic organic compounds.

专利号:WO-2014095657-A1
优先权日:2012-12-20
标题:Synthesis of a viral protease inhibitor intermediate
发明人：RIVA SERGIO; ALLEGRINI PIETRO; ATTOLINO EMANUELE; GRAZIOSI RENZO
权利人:DIPHARMA FRANCIS SRL
摘要:Synthesis of an intermediate useful in the synthesis of a viral protease inhibitor, and its use in the preparation of said inhibitor.

专利号:US-2003083352-A1
优先权日:2000-07-31
标 题 :Synthesis of imidazole intermediates
发明人：HELAL CHRISTOPHER J
权利人:PFIZER
摘要:The invention provides a method for synthesis of compounds of formula n n n wherein R 1 and R 19 are as defined. Compounds of formula 12 are useful as intermediates for synthesizing compounds having pharmacological activity inhibiting cdk5, cdk2, and GSK-3.

专利号:US-9862745-B2
优先权日:2004-03-30
标题 :Synthesis of boronic ester and acid compounds
发明人：AMMOSCATO VINCE; BISHOP JOHN E; CHIU FANG-TING; GEISER ACHIM; GOMEZ JEAN-MARC; HETT ROBERT; KOELLNER CHRISTOPH; KULKARNI VITHALANAND R; LO YOUNG; MUNK STEPHEN; PICKERSGILL I FRASER
权利人:MILLENNIUM PHARM INC; MILLENNIUM PHARM INC
摘要:The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.

专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人：SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.