CAS: 104040-78-0; N-((4,6-Dimethoxypyrimidin-2-yl)Carbamoyl)-3-(Trifluoromethyl)Pyridine-2-Sulfonamide

该化合物是一种以其针对广泛各种年长和常年草和宽叶草的选择性活性而闻名的灭蚁灵,其作用是抑制乙醇actate合成酶(ALS),这是分链氨基酸盐生物合成物中的关键酶,导致植物生长停止并最终死亡. Flazasulfront 以低应用率表现出高度的功效,使它在非作物区,草皮和某些园艺作物中成为控制杂草的经济选择.它有利的环境特征包括哺乳动物毒性低和土壤迅速退化,最大限度地减少残留影响.由于它采取了有针对性的行动,对非目标物种的影响最小,除草剂因其与综合除草管理系统的兼容性而特别受到重视.

结构式图片

相似化合物

208465-21-8 98389-04-9 128569-20-0

物理性质

欧盟法规

[欧盟农药活性物质

上下游产品

CAS号89392-03-0 4,6-二甲氧基-2-(苯氧基... | CAS号104040-76-8 3-(Trifluoromet... | CAS号111923-83-2 4,6-dimethoxypy... | CAS号111284-03-8 2-is°Cyanato-4,... | CAS号104040-76-8 3-(Trifluoromet...

合成工艺路线路线简述

  • 合成目标产物 Flazasulfuron 主要起始原料 4,6-Dimethoxy-2-(Phenoxycarbonyl)Aminopyrimidine And 3-(Trifluoromethyl)-2-Pyridinesulfonamide
  • (文献来源)合成步骤主要原料 4,6-Dimethoxy-2-(Phenoxycarbonyl)Aminopyrimidine 和 3-(Trifluoromethyl)-2-Pyridinesulfonamide
4,6-二甲氧基-2-(苯氧基羰基)氨基嘧啶,3-三氟甲基-2-吡啶磺酰胺置于三乙胺体系中,用 乙腈 用作溶剂,以85 %的收率获得啶嘧磺隆
参考文献:(杂)芳基羧酸肟酯的可见光诱导脱羧氨基磺酰化
标题:(杂)芳基羧酸肟酯的可见光诱导脱羧氨基磺酰化
摘要:磺酰胺是药物,农用化学品和有机催化剂中的重要结构,但这些化合物的快速,良性合成仍然是一个巨大的挑战.在此,我们报道了一种从(杂)芳基羧酸肟酯合成磺酰胺的光诱导方法.该反应通过能量转移介导的光催化作用,通过一锅级联自由基-自由基交叉偶联进行.广泛的底物范围,包括(杂)芳基底物和药物分子实体的后期修饰揭示了其普遍性.
Doi:10.1021/acs.Orglett.3C04142

专利信息


专利号:WO-2024256370-A1
优先权日:2023-06-13
标 题 :Synthesis of glufosinate using an amidase-based process
发明人:ZIMMERMANN GUNTHER; POTT MORITZ STEFAN
权利人:BASF SE
摘要:The present invention relates to a method of preparing glufosinate, comprising the steps of hydrolysing an N-carbamoyl glufosinate amide with an Amidase enzyme to form an N- carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N- carbamoyl amino acid compound.

专利号:US-2025120400-A1
优先权日:2021-12-10
标题:Synthesis of glufosinate using a hydantoinase-based process
发明人:DITRICH KLAUS; BREUER MICHAEL; POTT MORITZ STEFAN; ZIMMERMANN GUNTHER; SEEMAYER STEFAN
权利人:BASF SE
摘要:The present invention relates to a method of manufacturing glufosinate, comprising the steps of hydrolysing a hydantoin with a Hydantoinase enzyme to form a N-carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N-carbamoyl amino acid compound.

专利号:WO-2021130756-A1
优先权日:2019-12-25
标题:Combinations of non-protein amino acids and acetolactate synthase enzyme inhibitors
发明人:KLIPCAN LIRON; VAN-OSS PINHASI RUTH
权利人:THE STATE OF ISRAEL MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT AGRICULTURAL RES ORGANIZATION ARO VO
摘要:The present invention provides compositions and methods for disrupting protein synthesis in plant cells.

专利号:US-11919928-B2
优先权日:2016-03-16
标题 :Method for producing dihydrotentoxin
发明人:KUBO TAKASHI; MACHIDA MASAYUKI; FUJIOKA TOMONORI; YAMAGUCHI Shigenari; KAWAI KIYOSHI
权利人:KUMIAI CHEMICAL INDUSTRY CO
摘要:An object of the present invention is to identify an enzyme having activity of synthesizing dihydrotentoxin that is a tentoxin precursor and an enzyme having activity of synthesizing tentoxin using dihydrotentoxin as a substrate. The present invention concerns a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 16 and having activity of nonribosomal peptide synthesis of dihydrotentoxin and a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 18 and having activity of converting dihydrotentoxin to tentoxin.

专利号:US-2021386068-A1
优先权日:2018-11-07
标题 :Compositions comprising pyridine carboxylate herbicides and very long chain fatty acid (vlcfa) synthesis inhibitor herbicides
发明人:KISTER JEREMY; SATCHIVI NORBERT M
权利人:CORTEVA AGRISCIENCE LLC
摘要:Disclosed herein are compositions comprising (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a VLCFA synthesis inhibitor herbicide. Also disclosed herein are methods of controlling undesirable vegetation, comprising applying to vegetation or an area adjacent the vegetation or applying in soil or water to control the emergence or growth of vegetation (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof, and (b) a VLCFA synthesis inhibitor herbicide.

专利号:US-2021352899-A1
优先权日:2018-11-07
标题 :Compositions comprising pyridine carboxylate herbicides and fatty acid and lipid synthesis inhibitor herbicides
发明人:KISTER JEREMY; SATCHIVI NORBERT M
权利人:CORTEVA AGRISCIENCE LLC
摘要:Disclosed herein are compositions comprising (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a fatty acid and lipid synthesis inhibitor (FA/LSI) herbicide, an agriculturally acceptable salt or ester thereof, or mixtures thereof. Also disclosed herein are methods of controlling undesirable vegetation, comprising applying to vegetation or an area adjacent the vegetation or applying in soil or water to control the emergence or growth of vegetation (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a fatty acid and lipid synthesis inhibitor (FA/LSI) herbicide, an agriculturally acceptable salt or ester thereof, or mixtures thereof.
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主要参考文献


1: Mandl K, Cantelmo C, Gruber E, Faber F, Friedrich B, Zaller JG. Effects of Glyphosate-, Glufosinate- and Flazasulfuron-Based Herbicides on Soil Microorganisms in a Vineyard. Bull Environ Contam Toxicol. 2018 Nov;101(5):562-569. doi: 10.1007/s00128-018-2438-x. Epub 2018 Sep 18.
2: Tahmasebi BK, Alcántara-de la Cruz R, Alcántara E, Torra J, Domínguez- Valenzuela JA, Cruz-Hipólito HE, Rojano-Delgado AM, De Prado R. Multiple Resistance Evolution in Bipyridylium-Resistant Epilobium ciliatum After Recurrent Selection. Front Plant Sci. 2018 May 28;9:695. doi: 10.3389/fpls.2018.00695.
3: Couderchet M, Vernet G. Pigments as biomarkers of exposure to the vineyard herbicide flazasulfuron in freshwater algae. Ecotoxicol Environ Saf. 2003 Jul;55(3):271-7. doi: 10.1016/s0147-6513(02)00064-7. 62(4):650-7. doi: 10.1016/j.chemosphere.2005.04.119. Epub 2005 Jun 28. 51(26):7717-21. doi: 10.1021/jf0347970. 40(1):177-80. doi: 10.1081/pfc-200034303. 25(23):23215-23226. doi: 10.1007/s11356-018-2422-3. Epub 2018 Jun 3.

合成参考文献


摘要:Directory of World Chemical Producers, Chemical Information Services, 9101 LBJ Frwy., Suite 310, Dallas, TX 75243, (214) 349-6200. Date downloaded: September 2009. Available from, as of Apr 20, 2011:
摘要:National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Flazasulfuron (104040-78-0). Available from, as of May 23, 2011:
摘要:US EPA; Estimation Program Interface (EPI) Suite. Ver. 4.1. Jan, 2010. Available from, as of Jun 16, 2011:
摘要:Franke C et al; Chemosphere 29: 1501-14 (1994)
摘要:MacBean C, ed. Flazasulfuron (104040-78-0). In: The e-Pesticide Manual, 15th Edition, Version 5.0.1 (2010). Surrey UK, British Crop Protection Council.
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