CAS: 174669-74-0; 2-Fluoropyridin-3-Ol

相似化合物

209328-85-8 55758-32-2 1227593-95-4

上下游产品

CAS号372-48-5 2-氟吡啶 | CAS号16867-03-1 2-氨基-3-羟基吡啶 | CAS号40263-57-8 2-碘-3-羟基吡啶 | CAS号186588-98-7 3-[(2S)-2-Azeti... | CAS号233766-72-8 3-Pyridinol,2-(... | CAS号850142-72-2 6-溴-2-氟-3-吡啶醇 | CAS号163234-74-0 2-氟-3-甲氧基吡啶

2-氟吡啶置于lithium Diisopropyl Amide,硼酸三甲酯,过氧乙酸体系中,用 四氢呋喃,正己烷,溶剂黄146 用作溶剂,化学反应 3.5H,以92%的收率获得2-氟-3-羟基吡啶
参考文献:用于代谢研究和脑吸收的氟化铁螯合剂的设计与合成
标题:用于代谢研究和脑吸收的氟化铁螯合剂的设计与合成
摘要:合成了一系列氟化3-羟基吡啶-4-酮,其中氟或氟化取代基连接在吡啶环的2-或5-位,以改善3-羟基吡啶-4-酮的化学和生物学性质.合成途径不同于将官能团引入预先形成的3-羟基吡啶-4-酮环的常规对应途径.本文中,我们介绍了一种新方法,该方法从含氟前体开始,并在稍后阶段引入吡啶环的3-和4-位上的两个羟基.在p ķ一游离配体的值及其铁配合物的亲和常数表明,氟的存在极大地改变了该值.1-辛醇和mops缓冲液(ph 7.4)之间的游离配体和相应的铁(III)配合物的分布系数值也会受到影响.选定的氟化3-羟基吡啶-4-酮的葡萄糖醛酸化和氧化研究表明,某些此类氟化化合物比去铁酮具有明显的优势,因为它们的代谢速度较慢.血脑屏障通透性研究表明,尽管亲脂性会影响通透性,但这不是唯一因素.与去铁酮相比,七个氟3-羟基吡啶-4-酮中的两个具有改善的大脑分布.
Doi:10.1021/jm201475U

专利信息

专利号:US-2024239799-A1
优先权日:2021-04-02
标 题:(s)-1-(5-((pyridin-3-yl)thio)pyrazin-2-yl)-4'h,6'h-spiro[piperidine-4,5'-pyrrolo [1,2-b]pyrazol]-4'-amine derivatives and similar compounds as shp2 inhibitors for the treatment of e.g. cancer
发明人：DI FABIO ROMANO; MONTALBETTI CHRISTIAN; PETROCCHI ALESSIA; GRILLO ALESSANDRO; RANDAZZO PIETRO; ROSSETTI ILARIA; CIAMMAICHELLA ALINA
权利人:C N C C S S C A R L COLLEZIONE NAZ DEI COMPOSTI CHIMICI E CENTRO SCREENING; IRBM S P A
摘要:The present invention relates to compounds of formula (I). The compounds of the formula (I) are e.g. (S)-1-(5-((pyridin-3-yl)thio) pyrazin-2-yl)-41H,6′H-spiro[piperidine-4,5′-pyrrolo[1,2-b]pyrazol]-41-amine derivatives and similar compounds. The present invention also relates to the compounds of formula (I) for use as Src homology phosphotyrosine phosphatase 2 (SHP2) inhibitors in methods of treatment of e.g. cancer, cardiovascular diseases, immunological disorders, autoimmune disorders, fibrosis, ocular disorders, systemic lupus erythematosus, diabetes, neutropenia, and combinations thereof. The present invention also relates to pharmaceutical compositions containing said compounds and to their methods of synthesis.

专利号:US-11229713-B2
优先权日:2014-11-25
标题:Methods and compositions for 18F-radiolabeling of biologics
发明人：DONNELLY DAVID
权利人:BRISTOL MYERS SQUIBB CO
摘要:The invention relates to water soluble 18 F-prosthetic groups and the synthesis and use of 18 F-labeled biological molecules containing the 18 F-prosthetic groups for imaging various processes within the body, for detecting the location of molecules associated with disease pathology, and for monitoring disease progression are disclosed.

专利号:US-11806409-B2
优先权日:2016-06-01
标题 :Imaging methods using 18F-radiolabeled biologics
发明人：DONNELLY DAVID; LEUNG DAVID K
权利人:BRISTOL MYERS SQUIBB CO
摘要:The invention relates to water soluble 18 F-prosthetic groups and the synthesis and use of 18 F-labeled biological molecules containing the 18 F-prosthetic groups for imaging various processes within the body, for detecting the location of molecules associated with disease pathology, and for monitoring disease progression are disclosed.

专利号:CN-117024334-A
优先权日:2023-07-20
标 题:A kind of synthesis method of 2-fluoro-3-hydroxypyridine