CAS: 2166-31-6; 6-Phenylpyridazin-3(2H)-One

相似化合物

52240-08-1 2166-32-7 586950-22-3

上下游产品

6-phenyl-2,3,4,5-tetrahydropyridazin-3-one 4-chloro-6-phenylpyridazin-3(2H)-one 3-Butoxy-6-phenyl-pyridazine acetophenone H-pyridazin-3-one2-(2-morpholin-4-yl-ethyl)-6-phenyl-2H-pyridazin-3-one H-pyridazin-3-one2-(3-morpholin-4-yl-propyl)-6-phenyl-2H-pyridazin-3-one 2-(2-hydroxyethyl)-6-phenyl-3(2H)-pyridazinone 2-(4-Bromobutyl)-3-oxo-6-phenyl-2,3-dihydropyridazine

3-苯丙烯溴酸酯置于溴,一水合肼,溶剂黄146体系中,用 乙醇 用作溶剂,化学反应生成6-苯基-3-哒嗪酮
参考文献:作为环氧合酶 2 抑制剂的新型 N-取代苯基-6-氧代-3-苯基哒嗪衍生物的合成.
标题:作为环氧合酶 2 抑制剂的新型 N-取代苯基-6-氧代-3-苯基哒嗪衍生物的合成.
摘要:一些新型的非致溃疡性 N-取代苯基-6-氧代-3-苯基哒嗪作为 Cox-2 抑制剂被开发出来(补充材料附录 1).通过 6-苯基哒嗪-3( 2H )-One 与 4-氟苯甲醛反应制备了新型醛3.醛3与不同的肼和噻唑啉-4-酮反应得到新型n-取代苯基-6-氧代-3-苯基哒嗪衍生物.评估了它们的抗炎潜力和胃溃疡形成作用.还进行了分子对接研究.光谱数据与化合物的分配结构一致.化合物4A (Ic 50 = 17.45 Nm;P < .05),4B (Ic 50 = 17.40 Nm; P < .05),5A (Ic 50 = 16.76 Nm; P < .05) 和10 (Ic 50 = 17.15 Nm; P < .05) 比塞来昔布(ic 50 = 17.79 Nm;P < .05).这些发现与4A,4B,5A和10的分子对接研究一致.在体内的抗炎轮廓图4A,图4B,图5A,和10也优于塞来昔
Doi:10.1002/ddr.21655

专利信息

专利号:US-4152517-A
优先权日:1977-10-19
标题:Synthesis of 6-(2-hydroxyphenyl)-3(2H)-pyridazinones from trihalocarbinols
发明人：LEVINSON SIDNEY H; MENDELSON WILFORD L
权利人:SMITHKLINE CORP
摘要:A new synthesis for the preparation of 6-(2-hydroxyphenyl)-3-pyridazinones whose key reaction is cyclizing a 1,1,1-trihalo-2-hydroxy-4-(2-hydroxyphenyl)-1-butanone with hydrazine. 6-(2-Hydroxyphenyl)-3-pyridazinones are important intermediates for preparing medicinally active compounds.

专利号:RU-2135491-C1
优先权日:1993-10-01
标 题:Derivatives of n-phenyl-2-pyrimidineamine, method of their synthesis, pharmaceutical composition on said and method of inhibition (treatment) of tumor

专利号:CN-115557900-B
优先权日:2022-11-11
标 题:Synthesis method of 3-substituted pyridazine derivative