氯乙烷,Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于乙醚体系中,化学反应生成乙基氯化镁 参考文献:Gilman Et Al.,Recueil Des Travaux Chimiques Des Pays-Bas,1935,Vol. 54,P. 588 标题:Gilman Et Al.,Recueil Des Travaux Chimiques Des Pays-Bas,1935,Vol. 54,P. 588
专利号:US-11247977-B2 优先权日:2018-06-22 标题 :Compound and use thereof in synthesis of brivaracetam intermediate and crude drug 发明人:FENG YAN; WANG RUYONG; YE YIZHANG; ZHANG FENGSEN; GONG XUAN; WANG ZHONGHONG; KANG XINSHAN 权利人:FUJIAN HAIXI PHARMACEUTICALS CO LTD 摘要:The present application provides a compound in formula III, and further provides a use of the compound in the synthesis of a Brivaracetam intermediate and a crude drug, and a synthesis method. A raw material involved in the method of the present application is low in costs and easily available; (R)-4-propyl-dihydrofuran-2-ketone having high optical purity can be prepared; complicated separation and purification steps are avoided; costs are reduced, and the method is more applicable to industrial production.
专利号:US-10040752-B2 优先权日:2015-08-24 标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof 发明人:MKRTCHYAN GNEL; YAO QINGWEI 权利人:CODY LABORATORIES INC 摘要:Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are provided comprising administering a composition comprising an effective amount of levomethadone hydrochloride having not more than 10 ppm dextromethadone.
专利号:US-10000432-B2 优先权日:2014-01-13 标 题 :Processes for the synthesis of chiral 1-alkanols 发明人:NEGISHI EI-ICHI 权利人:PURDUE RESEARCH FOUNDATION 摘要:The invention relates to highly enantioselective processes for the synthesis of chiral 1-alkanols via Zr-catalyzed asymmetric carboalumination of alkenes.
专利号:US-4501921-A 优先权日:1982-11-18 标题 :Synthesis of alkylidene intermediates 发明人:RYAN CHARLES W; SLOMSKI BRUCE A 权利人:LILLY CO ELI 摘要:A stereo-selective preparation of novel sulfonated o-phenylenediamines carrying a trans-α-alkylidenebenzyl group at the 5-position, which are intermediates in the synthesis of antiviral benzimidazoles.
专利号:US-2010137659-A1 优先权日:2006-09-26 标题 :Process for the synthesis of 2,2',6-tribromobiphenyl 发明人:LEROUX FREDERIC; BONNAFOUX LAURENCE; COLOBERT FRANCOISE 权利人:LEROUX FREDERIC; BONNAFOUX LAURENCE; COLOBERT FRANCOISE 摘要:A process for the synthesis of 2,2′,6-tribromobiphenyl.
专利号:US-6814895-B2 优先权日:2000-12-20 标 题:Process for the synthesis of 1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-one 发明人:CVETOVICH RAYMOND; ASAI TOMOYUKI; YODOGAWA YOSHIKO 权利人:MERCK & CO INC 摘要:The present invention is concerned with a novel process for the preparation of 1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-one (CAS 30071-93-3). This compound is useful as an intermediate in the synthesis of therapeutic agents.
摘要:Gandon, V.; Malacria, M., Science of Synthesis, (2008) 44, 219. 摘要:Aitken, R. A.; Aitken, K. M., Science of Synthesis, (2010) 47, 1044. 摘要:Kantchev, E. A. B.; Organ, M. G., Science of Synthesis, (2009) 48, 38. 摘要:Wu, X.-F., Science of Synthesis Knowledge Updates, (2014) 1, 294. 摘要:Cherkinsky, M.; Levinger, S., Science of Synthesis, (2010) 47, 482.