专利号:US-12421534-B2 优先权日:2021-11-10 标 题 :Engineered enzymes and method for the synthesis of diverse tyrosine analogs 发明人:ALMHJELL PATRICK J; ARNOLD FRANCES H 权利人:CALIFORNIA INST OF TECHN 摘要:Provided herein is an engineered tryptophan synthase β-subunit (TrpB) that catalyzes the synthesis of tyrosine, tyrosine analogs, or salts thereof. Also provided herein are methods for preparing tyrosine, tyrosine analogs, or a salt thereof using the engineered TrpB described herein.
专利号:US-10287412-B2 优先权日:2012-10-18 标题:Process for the preparation of hierarchically meso and macroporous structured materials 发明人:KARTHIK MANI; FAIK ABDESSAMAD; DOPPIU STEFANIA 权利人:CIC ENERGIGUNE 摘要:The present invention describes a hierarchical graphitized carbon foam comprising an interconnected macroporous structure with an ordered mesoporous wall structure, a process for its preparation, as well as to a process for the synthesis of a variety of bimodal porous organic polymer and/or inorganic metal oxide materials.
专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:US-2016318862-A1 优先权日:2013-09-25 标 题:Synthesis of delta 12-pgj3 and related compounds 发明人:NICOLAOU KYRIACOS C; HERETSCH PHILIPP; HALE CHRISTOPHER R H; EL GHZAOUI ABDELLATIF EL MARROUNI; PULUKURI KIRAN KUMAR; YU RUOCHENG; GROVE CHARLES 权利人:UNIV RICE WILLIAM M 摘要:In one aspect, the present invention provides novel derivatives of Δ 12 -PGJ 3 and modular synthetic pathways to obtaining Δ 12 -PGJ 3 and derivatives thereof. In some aspects, the present derivatives of Δ 12 -PGJ 3 are useful as chemotherapeutic agents. The present disclosure also describes compositions of these derivatives as well as methods of use of the derivatives thereof.
专利号:US-2015293109-A1 优先权日:2012-10-29 标题 :Fluorescent Chemical Dye for Visualization of Neural Stem Cell Symmetric and Asymmetric Division 发明人:CHANG YOUNG-TAE; YUN SEONG-WOOK; HA HYUNG HO 权利人:UNIV SINGAPORE; AGENCY SCIENCE TECH & RES 摘要:A fluorescent rosamine dye having specificity for neural stem cells, specifically, proliferative neural stem cells, and represented by Structural Formula (I): wherein X is an anion, is described herein. Synthesis of the fluorescent rosamine dye and use of the fluorescent rosamine dye to detect symmetric and asymmetric division of neural stem cells are also described.
专利号:US-4288386-A 优先权日:1979-05-18 标 题:Ullmann reaction for the synthesis of diaryl ethers 发明人:SOULA GERARD; LINGUENHELD LOUIS 权利人:RHONE POULENC IND 摘要:The Ullman reaction for the preparation of diaryl ethers by coupling aryl halides with metal phenolates is conducted in the presence of at least one tertiary amine sequestering agent having the formula: n n N--CHR.sub.1 --CHR.sub.2 --O--CHR.sub.3 --CHR.sub.4 --O--.sub.n R.sub.5 n n ] 3