CAS: 40161-55-5; 1-Bromo-4-Fluoro-2-(Trifluoromethyl)Benzene

上下游产品

N-acetyl-3-trifluoromethylbenzenamine N-(4-bromo-3-trifluoromethylphenyl)acetamide 4-bromo-3-(trifluoromethyl)aniline 3-trifluoromethylaniline 2-bromo-5-fluoro-1-nitro-3-trifluoromethyl-benzene (3R)-1-(4-fluoro-2-(trifluoromethyl)phenyl)-3-methylpiperazine 2-[4-bromo-3-(trifluoromethyl)phenoxy]ethanol (2,3-dihydrobenzo[1,4]oxazin-4-yl)[3-(4-fluoro-2-(trifluoromethyl)phenyl)-2,5-dihydropyrrol-1-yl]methanone

邻溴三氟甲苯置于potassium Fluoride,Potassium Tetrafluorocobaltate体系中,用 二甲基亚砜 作为反应溶剂,化学反应 5.0H,以96.7%的收率获得产物2-溴-5-氟三氟甲苯
参考文献:一种2-溴-5-氟三氟甲苯的合成方法
标题:一种2-溴-5-氟三氟甲苯的合成方法
摘要:本发明涉及2‑溴‑5‑氟三氟甲苯的合成方法,包括如下步骤:以三氟甲苯为原料,先将三氟甲苯和硫酸,溴化钾,溴化亚铜,催化剂混合,进行溴化反应得到2‑溴三氟甲苯;将得到的2‑溴三氟甲苯于dmso溶剂中,加入氟化钾和kcof4进行氟化反应,得到2‑溴‑5‑氟三氟甲苯.本发明以三氟甲苯为原料,是全新的合成路线,溴化和氟化条件温和,反应产率高,所用的原料易购且价格低廉,因此该方法具有较高的工业应用价值.

专利信息

专利号:US-8008504-B2
优先权日:2005-06-09
标题 :Process for the synthesis of organic compounds
发明人：ABEL STEPHAN; ACEMOGLU MURAT; ERB BERNHARD; KRELL CHRISTOPH; SCLAFANI JOSEPH; MEISENBACH MARK; PRASHAD MAHAVIR; SHIEH WEN-CHUNG; XUE SONG
权利人:NOVARTIS AG
摘要:The present invention provides an efficient, safe and cost effective way to prepare 5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine which is a key intermediate for the preparation of substituted pyrimidinylaminobenzamides of formula (II):

专利号:US-2008200692-A1
优先权日:2005-06-09
标 题:Process For the Synthesis of Organic Compounds

专利号:ES-2380489-T3
优先权日:2005-06-09
标 题 :Process for the synthesis of organic compounds

专利号:ES-2465522-T3
优先权日:2005-06-09
标 题:Process for the synthesis of organic compounds

专利号:CA-2611280-A1
优先权日:2005-06-09
标题 :Processes for the synthesis of 5-(4-methyl-1h-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine and its intermediates

专利号:CA-2833394-C
优先权日:2005-06-09
标题 :Processes for the synthesis of 5-(4-methyl-1h-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine and its intermediates