CAS: 40172-95-0; 1-(2-Furoyl)Piperazine

上下游产品

CAS号527-69-5 糠酰氯 | CAS号142-63-2 哌嗪(六水) | CAS号110-85-0 哌嗪 | CAS号88-14-2 糠酸; 2-糠酸; 2-呋喃甲酸 | CAS号999-97-3 六甲基二硅氮烷 | CAS号611-13-2 2-糠酸甲酯 | CAS号614-99-3 2-糠酸乙酯 | CAS号57260-71-6 1-B°C-哌嗪 | CAS号111218-71-4 [4-(4-amino-7-c... | CAS号111218-75-8 1-(4-Amino-7-ch... | CAS号111218-74-7 1-(4-Amino-6,8-... | CAS号111218-73-6 1-(4-Amino-6-br... | CAS号67817-56-5 N-(2-cyano-4,5-...

糠酸(呋喃甲酸)置于potassium Carbonate,Methanaminium,N-[(Dimethylamino)(3H-1,2,3-Triazolo[4,5-B]Pyridin-3-Yloxy)Methylene]-N-Methyl-,Hexafluorophosphate(1-),三氟乙酸体系中,用 二氯甲烷,丙酮 作为反应溶剂,化学反应 0.5H,反应生成 1-(2-糠酰)哌嗪
参考文献:高亲和力和低 Parp 捕获苯并咪唑衍生物作为 Parp1 降解剂的潜在弹头
标题:高亲和力和低 Parp 捕获苯并咪唑衍生物作为 Parp1 降解剂的潜在弹头
摘要:Parpi已被探索并应用于治疗多种癌症,效果显着,特别是brca1/2突变的卵巢癌,乳腺癌,前列腺癌和胰腺癌.然而,由于parp-Trapping和长期的临床跟踪,Parpi不可避免地产生耐药性并表现出高毒性.为了克服 Parpi 的耐药性和高毒性,人们开发了许多新方法,包括 Protac.作为一种事件驱动技术,Protac 需要高亲和力,低毒性的弹头,并且在结合过程中没有空间位阻. Veliparib显示出最低的parp捕获效果,但由于强烈的空间位阻,很难成为protac的弹头.其他 Parp1 抑制剂表现出较小的空间位阻,但具有较高的 Parp 捕获效果.因此,开发具有高parp1亲和力,低parp1捕获且无空间位阻的新型弹头将是有价值的.在这项工作中,我们保留苯并咪唑作为基序以保留低parp1捕获效应,并用芳环取代吡咯以避免parp1结合洞中的空间位阻.因此,设计并合成了一系列苯并咪
DOI:10.1016/j.Ejmech.2024.116405

专利信息

专利号:US-6080860-A
优先权日:1992-08-31
标 题:Methods of making ureas and guanidines including, terazosin, prazosin, doxazosin, tiodazosin, trimazosin, quinazosin and bunazosin (exemplary of 2-substituted quinazoline compounds), and meobentine, and bethanidine and intermediates therefor
发明人：KARIMIAN KHASHAYAR; MURTHY KESHAVA; HALL DARREN
权利人:BRANTFORD CHEMICALSS INC
摘要:Novel methods for the synthesis of substituted ureas and guanidines including Terazosin, Prazosin, Doxazosin, Tiodazosin, Trimazosin, Quinasin and Bunazosin (exemplary of 2-amino substituted Quinazolines), Meobentine and Bethanidine and novel intermediates suitable for use in such methods of synthesis are taught.

专利号:US-2008039473-A1
优先权日:2006-08-08
标题:Preparation and utility of substituted quinazoline compounds with alpha-adrenergic blocking effects
发明人：GANT THOMAS G; SARSHAR SEPEHR
权利人:AUSPEX PHARMACEUTICALS INC
摘要:The present disclosure is directed to modulators of alpha-adrenergic receptors and pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and the use of such compounds for the treatment and/or management of hypertension, cardiac failure, prostatitis, and benign prostatic hyperplasia, and any other condition in which it is beneficial to modulate an alpha-adrenergic receptor.

专利号:US-8829014-B2
优先权日:2006-04-07
标题 :Thiazole and thiophene analogues, and their use in treating autoimmune diseases and cancers
发明人：GIORDANO ANTHONY; VASU KAMALA K; THAKAR HARDIK M; GIRI RAJAN S; SUDARSANAM VASUDEVAN; YERANDE SWAPNIL G; INAMDAR GAJANAN S
权利人:GIORDANO ANTHONY; VASU KAMALA K; THAKAR HARDIK M; GIRI RAJAN S; SUDARSANAM VASUDEVAN; YERANDE SWAPNIL G; INAMDAR GAJANAN S; UNIV LOUISIANA STATE; PATEL PHARMACEUTICAL EDUCATION & RES DEV PERD CT B V
摘要:Thiazole and thiophene compounds are disclosed having utility in treating inflammatory conditions, immunoinflammatory conditions, autoimmune diseases, and cancers. Methods for the synthesis of these compounds are also disclosed.

专利号:US-6417195-B1
优先权日:1999-02-22
标题 :Isoquinoline derivatives and isoquinoline combinatorial libraries
发明人：LEBL MICHAL
权利人:LION BIOSCIENCE AG
摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinoline derivatives as well as novel libraries comprised of such compounds.

专利号:WO-9405628-A1
优先权日:1992-08-31
标 题 :Synthesis of 2-substituted quinazoline compounds (such as terazosin) and meobentine and bethanidine and intermediates therefor

专利号:EP-0656885-A1
优先权日:1992-08-31
标 题 :Synthesis of 2-substituted quinazoline compounds (such as terazosin) and meobentine and bethanidine and intermediates therefor