CAS: 482-36-0; 2-(3,4-Dihydroxyphenyl)-5,7-Dihydroxy-3-(((2S,3R,4S,5R,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)-4H-Chromen-4-One

上下游产品

CAS号117-39-5 槲皮素 | CAS号357194-03-7 2-(2,2-diphenyl... | CAS号742062-20-0 2-(2,2-diphenyl... | CAS号53209-27-1 2''-O-没食子酰基金丝桃苷 | CAS号59-23-4 半乳糖 | CAS号117-39-5 槲皮素 | CAS号10257-28-0 D-吡喃葡萄糖 | CAS号7296-64-2 β-D-半乳糖

3-O-(2'',3'',4'',6''-Tetra-O-Acetyl-β-D-Galactopyranosyl)-3',4',5,7-Tetrahydroxyflavonol置于sodium Methylate体系中,用 甲醇 作为反应溶剂,化学反应 1.0H,以81%的收率获得产物金丝桃苷
参考文献:槲皮素-3-β-半乳糖苷及其合成衍生物与 Sars-Cov 3Cl(Pro) 的结合相互作用:结构-活性关系研究揭示了显着的药效团特征.
标题:槲皮素-3-β-半乳糖苷及其合成衍生物与 Sars-Cov 3Cl(Pro) 的结合相互作用:结构-活性关系研究揭示了显着的药效团特征.
摘要:严重急性呼吸综合征相关冠状病毒 (Sars-Cov) 的 3C 样蛋白酶 (3Cl(Pro)) 是发现抗 Sars 药物最有希望的靶标之一,因为它在病毒生命周期中发挥着关键作用.在这项研究中,通过分子对接,基于 Spr/fret 的生物测定和诱变研究,一种名为槲皮素-3-β-半乳糖苷的天然化合物被鉴定为蛋白酶的抑制剂.分子模型和 Q189A 突变都表明 Gln189 在结合中起着关键作用.此外,实验证据表明,Sars-Cov 3Cl(Pro)的二级结构和酶活性不受q189A突变的影响.在分子建模的帮助下,设计并合成了八种新的天然产物衍生物.生物测定结果揭示了新化合物构效关系的显着特征:(1)槲皮素部分7-羟基的去除降低了衍生物的生物活性;(2)糖部分的乙酰氧基化消除了抑制剂作用;(3)槲皮素7-羟基上引入大的糖取代基是可以耐受的;(4)用其他糖替代半乳糖部分不影响抑制剂效力.这项研究不仅揭示了一类新的化合物作为对抗
DOI:10.1016/j.Bmc.2006.09.014

专利信息

专利号:US-2002165207-A1
优先权日:2001-05-02
标题 :Compositions and methods for the treatment of diabetic neuropathy
发明人：ROSENBLOOM RICHARD
摘要:Compositions and a method for the treatment of diabetic neuropathy is disclosed. The compositions comprise a mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant, optionally formulated in a pharmaceutically acceptable carrier. This combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In addition, the compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is administered on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms of diabetic neuropathy, as well as at least some recovery of the damaged nerve tissues.

专利号:US-2007232495-A1
优先权日:2006-03-24
标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof
发明人：NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.

专利号:US-7854946-B1
优先权日:2007-05-31
标题:Anti-inflammatory and anti-HIV compositions and methods of use
发明人：HILLWIG MATTHEW LEE
权利人:UNIV IOWA STATE RES FOUND INC
摘要:The metabolic fingerprint and anti-inflammatory activity and anti-HIV activity of H. gentianoides is disclosed. High performance liquid chromatography (HPLC) analysis shows that H. gentianoides contains a family of compounds, including some not previously observed in other Hypericum species. H. gentianoides extracts and fractions from these extracts reduce prostaglandin E2 synthesis in mammalian macrophages and inhibit HIV in infected HeLa cells. The present invention provides extracts and fractions thereof from H. gentianoides for use in pharmaceutical compositions and methods for the treatment or inhibition of inflammation, prostaglandin E-mediated disease, disorder or condition, a cyclooxygenase-mediated disease, disorder or condition, or an HIV infection.

专利号:CN-109762163-A
优先权日:2019-01-11
标 题:A kind of synthesis and application method of loaded hypericin

专利号:CN-101205223-B
优先权日:2006-12-18
标题:A kind of total synthesis method of natural product icariin compound

专利号:RO-137147-A2
优先权日:2021-05-31
标题 :PHYTOTHERAPEUTIC PRODUCT FOR NATURAL STIMULATION OF COLLAGEN SYNTHESIS AND PROCEDURE FOR OBTAINING