CAS: 75-75-2; Methanesulfonic Acid

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CAS号74-93-1 甲硫醇 | CAS号34557-54-5 methane | CAS号73153-55-6 2-Benzamidophen... | CAS号74-88-4 碘甲烷 | CAS号624-92-0 二甲基二硫醚 | CAS号77-78-1 硫酸二甲酯 | CAS号2949-92-0 甲基硫代磺酸甲酯 | CAS号66-27-3 甲基磺酸甲酯 | CAS号556-64-9 硫氰酸甲酯 | CAS号1048007-93-7 Masitinib甲磺酸盐 | CAS号1077-02-7 (3-methylphenyl... | CAS号1095565-87-9 (5S)-2-[(1S,2S,... | CAS号3570-58-9 甲磺酸2-氯乙酯 | CAS号80520-50-9 1-chlorododecan... | CAS号1373360-84-9 2-oxododecyl me... | CAS号1352167-40-8 1-chloro-5-(dib... | CAS号58131-47-8 甲基磺酸钙 | CAS号3517-90-6 4-甲氧基苯急家基砜

甲磺酸正丁酯置于邻苯二甲酸二丁酯,水体系中,化学反应 3.0H,反应生成 甲烷磺酸
参考文献:Removal Of Alkyl Alkanesulfonate Esters From Alkanesulfonic Acids And Other Organic Media
标题:Removal Of Alkyl Alkanesulfonate Esters From Alkanesulfonic Acids And Other Organic Media
摘要:提供了从水性或无水性组合物中去除烷基烷磺酸酯的方法.该发明提供了将化学式为rso3R'的烷基烷磺酸酯转化为化学式为rso3H的相应酸的方法.烷基烷磺酸酯存在于有机介质中,该介质可能含有大量水,也可能是无水或基本无水的.在某些实施例中,该发明提供了通过去除烷基烷磺酸酯来净化水性或无水烷磺酸的方法.

专利信息

专利号:US-6504041-B2
优先权日:1996-11-15
标题 :Synthesis of ruthenium or osmium metathesis catalysts
发明人：GRUBBS ROBERT H; BELDERRAIN TOMAS R; BROWN SETH N; WILHELM THOMAS E
权利人:CALIFORNIA INST OF TECHN
摘要:The present invention relates to the synthesis of highly active ruthenium and osmium carbene metathesis catalyst in good yield from readily available starting materials. The catalysts that may be synthesized are of the general formula n wherein: n M is ruthenium or osmium; n X and X 1 are independently any anionic ligand; n L and L 1 are any neutral electron donor ligand; and, n R and R 1 are each hydrogen or one of the following substituent groups: C 2 -C 20 alkenyl, C 2 -C 20 alkynyl, C 1 -C 20 alkyl, aryl, C 1 -C 20 carboxylate, C 1 -C 20 alkoxy, C 2 -C 20 alkenyloxy, C 2 -C 20 alkynyloxy, aryloxy, C 2 -C 20 alkoxycarbonyl, C 1 -C 20 alkylthio, C 1 -C 20 alkylsulfonyl and C 1 -C 20 alkylsulfinyl. Optionally, the substituent group may be substituted with one or more groups selected from C 1 -C 5 alkyl, halogen, C 1 -C 5 alkoxy, and aryl. When the substitute aryl group is phenyl, it may be further substituted with one or more groups selected from a halogen, a C 1 -C 5 alkyl, or a C 1 -C 5 alkoxy. Specific synthetic protocols for vinyl alkylidene catalysts wherein R is hydrogen and R 1 is —CHCR 12 R 13 and non-vinyl alkylidene catalysts are also disclosed. In addition to the ease of synthesis (typically a one-step synthesis), the reactions generally may be run at or above room temperature and the resulting products usually may be used without extensive post synthesis purification.

专利号:US-9446995-B2
优先权日:2012-05-21
标 题:Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
发明人：CHONG HYUN-SOON
权利人:CHONG HYUN-SOON; ILLINOIS INST OF TECH
摘要:Stereoselective and regioselective synthesis of compounds via nucleophilic ring opening reactions of aziridinium ions for use in stereoselective and regioselective synthesis of therapeutic and diagnostic compounds.

专利号:US-12441721-B2
优先权日:2020-07-21
标 题 :Synthesis of heterocyclic compounds from carboxamide and carboxamide derivatives with haloalkanols
发明人：KARPOORMATH RAJSHEKHAR; SAYYAD NISAR
权利人:UNIV OF KWAZULU NATAL
摘要:The invention provides for methods for the synthesis of various compounds through reaction of carboxamide, or carboxamide derivatives, with various substituted or unsubstituted haloalkanols in a one-step, single vessel, reaction mechanism. Preferably, but not exclusively, the reaction proceeds in the absence of any solvents, catalyst, base, or any further reagents.

专利号:US-6794534-B2
优先权日:2000-06-23
标题:Synthesis of functionalized and unfunctionalized olefins via cross and ring-closing metathesis
发明人：GRUBBS ROBERT H; CHATTERJEE ARNAB K; MORGAN JOHN P; SCHOLL MATTHIAS; CHOI TAE-LIM
权利人:CALIFORNIA INST OF TECHN
摘要:The invention is directed to the cross-metathesis and ring-closing metathesis reactions between geminal disubstituted olefins and terminal olefins, wherein the reaction employs a Ruthenium or Osmium metal carbene complex. Specifically, the invention relates to the synthesis of α-functionalized or unfunctionalized olefins via intermolecular cross-metathesis and intramolecular ring-closing metathesis using a ruthenium alkylidene complex. The catalysts preferably used in the invention are of the general formula n wherein: n M is ruthenium or osmium; n X and X 1 are each independently an anionic ligand; n L is a neutral electron donor ligand; and, n R, R 1 R 6 , R 7 , R 8 , and R 9 are each independently hydrogen or a substituent selected from the group consisting of C 1 -C 20 alkyl, C 2 -C 20 alkenyl, C 2 -C 20 alkynyl, aryl, C 1 -C 20 carboxylate, C 1 -C 20 alkoxy, C 2 -C 20 alkenyloxy, C 2 -C 20 alkynyloxy, aryloxy, C 2 -C 20 alkoxycarbonyl, C 1 -C 20 alkylthio, C 1 -C 20 alkylsulfonyl and C 1 -C 20 alkylsulfinyl.

专利号:WO-2013138200-A1
优先权日:2012-03-13
标 题 :Green chemistry synthesis of the malaria drug amodiaquine and analogs thereof
发明人：FORTUNAK JOSEPH MARIAN; KULKARNI AMOL ANANT; KING CHRISTOPHER
权利人:UNIV HOWARD
摘要:Methods are provided for a green chemistry one-pot synthesis of amodiaquine and amodiaquine analogs. The methods have a lower environmental impact, lower investment cost, reduced amounts of byproducts and impurities, and a shorter synthesis time, compared to current conventional synthesis methods. The methods reduce the total number of steps in the synthesis from four to five down to two, thereby simplifying production; and allow a reduced number of solvents and reagents to be used in production, thereby reducing the waste generated in the synthesis. The methods can reduce the waste to about 3-5 kilograms of waste generated per kilogram of product produced; and surprisingly improve the overall yield from 60-65% to greater than 90% as compared to the current conventional synthesis methods for amodiaquine and its analogs.

专利号:US-11873305-B2
优先权日:2020-06-30
标题 :Processes for synthesis of substituted indole intermediates for the synthesis of serd compounds
发明人：ZHANG HAIMING; XU JIE; WUITSCHIK GEORG; ANGELAUD REMY; HEROLD SEBASTIAN; STUTZ ALFRED; BRUETSCH TOBIAS; BURKHARD JOHANNES
权利人:GENENTECH INC; HOFFMANN LA ROCHE
摘要:Provided herein are processes for the preparation of indolyl intermediates using Wenker Synthesis for the total synthesis of SERD compounds useful in the treatment of cancer.