CAS: 13222-26-9; 2-Chloro-2-Methylpropanoyl Chloride

上下游产品

2-methyllactic acid 2-chloro-2-methylpropanoic acid isobutyryl chloride 1,1,1-trichloro-2-methyl-2-propanol 1-(4-bromophenyl)-2-chloro-2-methylpropan-1-one 1-chloro-2,4-bis-(α-chloro-isobutyryloxy)-benzene dimethylcarbamylmethyl chloride 2-chloro-2-methylpropanoic acid

2-甲基-2-羟基丙酸置于氯化亚砜,N,N-二甲基甲酰胺体系中,化学反应 2.0H,以83%的收率获得2-氯异丁酰氯
参考文献:平面手性钌配合物的不对称自动串联催化:顺序烯丙基酰胺化和原子转移自由基环化
标题:平面手性钌配合物的不对称自动串联催化:顺序烯丙基酰胺化和原子转移自由基环化
摘要:Ru完成了所有工作:描述了一个由平面手性环戊二烯基-钌络合物催化的不对称自串联反应的新例子.烯丙基氯与α-卤代酰胺的反应通过一锅顺序的烯丙基酰胺化/原子转移自由基环化反应提供了合成有用的,非对映异构和对映异构体富集的具有多个立体异构中心的γ-内酰胺.Pg =保护基.
Doi:10.1002/anie.201300485

专利信息

专利号:WO-2020246902-A1
优先权日:2019-06-07
标 题 :An initiator of atrp radical polymerisation, a method of its synthesis, and a method of synthesis of low-dispersion polymer and copolymer using this initiator
发明人：MEGIEL ELÅ»BIETA; ROMAŃSKI JAN; FEDORCZUK MAGDALENA
权利人:UNIV WARSZAWSKI
摘要:An initiator of ATRP radical polymerisation having a functional group with a substituent active in polymerisation process, is characterised in that it is a bifunctional initiator containing at least two functional groups separated by a hydrocarbon moiety Y, where the first functional group has an active substituent X and the second functional group has a protecting group Z, which can be chemically modified with the same or a different substituent than the active substituent X present in the first functional group. A method of synthesis of 2-chloro-N-(2-hydroxyethyl)propionamide initiator, NCPAE, is characterised in that ethanolamine is subjected to an acylation reaction with 2-chloropropionyl chloride in presence of triethylamine (TEA), wherein the reaction is carried out under inert atmosphere at room temperature.

专利号:US-2013165350-A1
优先权日:2011-12-22
标 题:Surface linkers for array synthesis
发明人：KUIMELIS ROBERT; MCGALL GLENN; PAO DEXTER; CHEN ZIHUI; AXELROD TREVOR
权利人:KUIMELIS ROBERT; MCGALL GLENN; PAO DEXTER; CHEN ZIHUI; AXELROD TREVOR; AFFYMETRIX INC
摘要:The present invention provide several methods of derivatizing a surface of a support with one or more linkers thus providing a suitable platform for synthesis of a polymer array, particular a nucleic acid array. Some methods derivatize a surface with a self-assembled monolayer (SAM) of a linker. The SAM confers advantages of hydrolytic stability, broad compatibility with synthesis and detection chemistries, and reduced emergence of latent functional groups during polymer array synthesis. Substrates can also be derivatized with multi-layers of SAMs providing greater hydrolytic stability. Substrates can also be derivatized by synthesizing a linker in situ on the substrate by atom transfer radical polymerization of functional and functional monomers. Appropriate selection of monomers reduces emergence of latent functional groups in subsequent array synthesis.

专利号:US-5221742-A
优先权日:1990-12-21
标 题 :Process for the preparation of 6-(3,4-dihydro-3-oxo-1,4(2h)-benzoxazin-7-yl)-2,3,4,5-tetrahydropyridazin-3-ones
发明人：COMBS DONALD W; DEMERS JAMES P
权利人:ORTHO PHARMA CORP
摘要:The invention relates to a process for the synthesis of compounds of the formula I ##STR1## wherein R 1 -R 5 are as defined herein. The process is a multistep process which comprises acylating a 2-benzoxazolinone with an alkanoic anhydride to form an acylated carbamate, hydrolyzing the carbamate, reacting the resultant aminophenol with haloalkanoyl halide to form a substituted benzoxazine, reacting the benzoxazine with an aldehyde, alkylating the resultant aminomethyl compound with an alkylating agent to form a quaternary ammonium salt, reacting the salt with an alkali metal cyanide to form a nitrile, hydrolyzing the nitrile and reacting the resultant carboxylic acid with hydrazine. n The compounds are useful as cardiotonic and vasodilating agents and as inhibitors of phosphodiesterase fraction III and platelet aggregation. In addition, the compounds are active as smooth muscle relaxants and bronchodilators.

专利号:PL-243003-B1
优先权日:2019-06-07
标题:ATRP radical polymerization initiator, method of its synthesis and method of synthesis of low-dispersion polymers and copolymers using this initiator

专利号:CN-113429308-A
优先权日:2021-06-16
标题 :The synthesis process of diclofenac sodium