CAS: 4124-41-8; 4-Methylbenzenesulfonic Anhydride

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CAS号104-15-4 对甲苯磺酸 | CAS号38542-71-1 4-methylbenzene... | CAS号108-88-3 甲苯 | CAS号58010-17-6 6-dichloromethy... | CAS号16836-95-6 对甲苯磺酸银 | CAS号98-59-9 对甲苯磺酰氯(PTSC) | CAS号6192-52-5 对甲苯磺酸一水合物 | CAS号55865-38-8 bis(trifluorome... | CAS号108-24-7 乙酸酐 | CAS号383-50-6 对甲苯磺酸氟乙酯 | CAS号1816-96-2 2,5-Dimethylphe... | CAS号191092-07-6 (R)-3-(甲苯磺酰氧基甲基... | CAS号640-57-3 4-甲基二苯砜 | CAS号26923-87-5 2-(2-hydroxyeth... | CAS号3386-35-4 对甲苯磺酸正辛酯 | CAS号105-60-2 己内酰胺 | CAS号778-28-9 对甲苯磺酸正丁酯 | CAS号80-48-8 对甲苯磺酸甲酯 | CAS号599-66-6 二对甲苯酰硫

1-甲基吡啶置于三氟甲磺酸酐,均三甲苯体系中,用 二氯甲烷 作为反应溶剂,以90%的收率获得产物4-甲苯磺酸酐
参考文献:用对甲苯磺酸甲酯作为磺化前体对芳族化合物进行磺酰化
标题:用对甲苯磺酸甲酯作为磺化前体对芳族化合物进行磺酰化
摘要:我们已经开发了以对甲苯磺酸甲酯为磺酰化前体的芳族化合物的friedel-Crafts(fc)磺酰化方法.在该方法中,对甲苯磺酸甲酯进行处理并用吡啶活化以产生作为磺酰化试剂的对甲苯磺酸n-甲基吡啶鎓.在三种不同的促进剂(如三氟甲磺酸酐,二甲基硫醚二三氟甲磺酸盐和三苯基膦二三氟甲磺酸盐(tppd))的存在下研究了该盐对均三甲苯磺酰化的反应性.所有启动子均显示化学选择性,其中,Tppd在fc磺酰化反应中显示化学选择性.
DOI:10.1007/s13738-011-0062-3

专利信息

专利号:US-4287123-A
优先权日:1980-01-14
标题 :Synthesis of thienamycin via (3SR, 4RS)-3-((RS)-1-acyloxyethyl)-2-oxo-4-azetidineacetate
发明人：LIU THOMAS M H; MELILLO DAVID G; RYAN KENNETH M; SHINKAI ICHIRO; SLETZINGER MEYER
权利人:MERCK & CO INC
摘要:Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: II wherein R is a readily removable carboxyl protecting group; and is a readily removable acyl group.

专利号:US-4384998-A
优先权日:1981-03-30
标题:Synthesis of thienamycin from D-glucose
发明人：DURETTE PHILIPPE L
权利人:MERCK & CO INC
摘要:Disclosed is a chiral, total synthesis of thienamycin from D-glucose which proceeds via intermediates I, II and III to known aldehyde IV which is known to be useful in the total synthesis of thienamycin (V): ##STR1## wherein: R is lower alkyl having 1-6 carbon atoms or bi-valent alkyl having 2-6 carbon atoms which joins the two sulfur atoms; R 1 is lower alkyl or aralkyl, such as benzyl and the like; and R 2 is hydrogen or a removable protecting group, such as triorganosilyl wherein the organo groups are independently selected from lower alkyl, phenyl and phenylloweralkyl.

专利号:US-4282148-A
优先权日:1980-01-14
标 题:Synthesis of thienamycin via esters of (3SR, 4RS)-3-[(SR)-1-hydroxyethyl]-β,2-dioxo-4-azetidinebutanoic acid
发明人：LIU THOMAS M H; MELILLO DAVID G; RYAN KENNETH M; SHINKAI ICHIRO; SLETZINGER MEYER
权利人:MERCK & CO INC
摘要:Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: II wherein R3 is a readily removable carboxyl protecting group.

专利号:US-4414155-A
优先权日:1980-01-14
标题 :Synthesis of thienamycin via esters of (3SR, 4RS)-3-[(SR)-1-hydroxyethyl]-β,2-dioxo-4-azetidinebutanoic acid
发明人：LIU THOMAS M H; MELILLO DAVID G; RYAN KENNETH M; SHINKAI ICHIRO; SLETZINGER MEYER
权利人:MERCK & CO INC
摘要:Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: II wherein R3 is a readily removable carboxyl protecting group.

专利号:US-4841045-A
优先权日:1985-03-12
标 题 :Synthesis of vinblastine and vincristine type compounds
发明人：KUEHNE MARTIN
权利人:UNIV VERMONT
摘要:A new process for the stereospecific synthesis of alkaloids of the vinblastine and vincristine type including the synthesis of vinblastine and vincristine as well novel alkaloids which are active as anti-tumor agents.

专利号:US-4448976-A
优先权日:1981-03-30
标题 :Chiral synthesis of thienamycin from D-gluocose
发明人：DURETTE PHILIPPE L
权利人:MERCK & CO INC
摘要:Disclosed is a chiral, total synthesis of thienamycin from D-glucose which proceeds via intermediates I, II and III to known aldehyde IV which is known to be useful in the total synthesis of thienamycin (V): ##STR1## wherein: R is lower alkyl having 1-6 carbon atoms or bi-valent alkyl having 2-6 carbon atoms which joins the two sulfur atoms; R 1 is lower alkyl or aralkyl, such as benzyl and the like; and R 2 is hydrogen or a removable protecting group, such as triorganosilyl wherein the organo groups are independently selected from lower alkyl, phenyl and phenylloweralkyl.