CAS: 5582-62-7; Trimethyl(Prop-2-Yn-1-Yloxy)Silane

该化合物是一种有硅保护的proparyl 酒精衍生物,通常在有机合成中作为一种多功能建筑块使用.三甲基硅酸酯组组增强了稳定性和控制反应性,使其在核生殖添加,交叉反应和点击化学应用方面有用.它的propargyl功能允许进一步衍生,包括基于烷基的转化和循环添加.该化合物在保护集体战略方面特别有用,在温和的条件下可以实现选择性的去保护.其湿度敏感度要求在惰性大气中处理,但其合成灵活性使它成为在制药和材料科学中构建复杂的分子结构的首选.

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上下游产品

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合成工艺路线路线简述

  • 合成目标产物 Propargyloxytrimethylsilane 主要起始原料 3-Trimethylsilyl-2-Oxazolidinone And Propargyl Alcohol
  • (文献来源)合成步骤主要原料 3-Trimethylsilyl-2-Oxazolidinone 和 Propargyl Alcohol
2-丙炔-1-醇 反应生成 丙炔氧基三甲基硅烷
参考文献:Synthesis Of Diosphenol Ethers By Means Of Alkoxytrimethylsilanes
标题:Synthesis Of Diosphenol Ethers By Means Of Alkoxytrimethylsilanes
摘要:
DOI:10.1016/s0040-4039(00)85105-9

海关参考信息

专利信息


专利号:US-2007099915-A1
优先权日:2005-10-07
标题 :Inhibitors of the hiv integrase enzyme
发明人:DRESS KLAUS R; JOHNSON TED W; PLEWE MICHAEL B; TANIS STEVEN P; ZHU HUICHUN
权利人:PFIZER
摘要:The present invention is directed to compounds of formula (I), n nand pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIVâ€?) integrase enzyme.

专利号:US-7468375-B2
优先权日:2004-04-26
标题:Inhibitors of the HIV integrase enzyme
发明人:DRESS KLAUS RUPRECHT; HU QIYUE; JOHNSON TED WILLIAM; PLEWE MICHAEL BRUNO; TANIS STEVEN PAUL; WANG HAI; YANG ANLE; YIN CHUNFENG; ZHANG JUNHU
权利人:PFIZER
摘要:The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIVâ€?) integrase enzyme.

专利号:EP-1873155-A1
优先权日:2004-04-26
标题:Inhibitors of the HIV integrase enzyme
发明人:DRESS KLAUS RUPRECHT; HU QIYUE; JOHNSON TED WILLIAM; PLEWE MICHAEL BRUNO; TANIS STEVEN PAUL; ZHU HUICHUN; ZHANG JUNHU
权利人:PFIZER
摘要:The present invention is directed to compounds of formula (I),n nand pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus ('HIV') integrase enzyme.

专利号:SU-1735300-A1
优先权日:1990-01-22
标题 :Method for synthesis of s-trimethylsilyl esters of dithio- or tetrathiophosphoric acids

专利号:US-7692014-B2
优先权日:2004-04-26
标题:Inhibitors of the HIV integrase enzyme
发明人:DRESS KLAUS RUPRECHT; HU QIYUE; JOHNSON TED WILLIAM; PLEWE MICHAEL BRUNO; TANIS STEVEN PAUL; ZHU HUICHUN; ZHANG JUNHU
权利人:PFIZER
摘要:The present invention is directed to compounds of formula (I), n nand pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIVâ€?) integrase enzyme.

专利号:US-6613942-B1
优先权日:1997-07-01
标题 :Glucagon antagonists/inverse agonists
发明人:LING ANTHONY; GREGOR VLAD; GONZALEZ JAVIER; HONG YUFENG; KIEL DAN; KUKI ATSUO; SHI SHENGHUA; NAERUM LARS; MADSEN PETER; SAMS CHRISTIAN; LAU JESPER; PLEWE MICHAEL BRUNO; FENG JUN; TENG MIN; JOHNSON MICHAEL DAVID; TESTON KIMBERLY ANN; SIDELMANN ULLA GROVE; KNUDSEN LOTTE BJERRE
权利人:NOVO NORDISK AS
摘要:Non-peptide compounds comprising a central hydrazide motif and methods for the synthesis thereof are disclosed. The compounds act to antagonize the action of the glucagon peptide hormone.
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合成参考文献


摘要:Aubert, C.; Malacria, M.; Ollivier, C., Science of Synthesis: Stereoselective Synthesis, (2011) 3, 234.
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