CAS: 57280-22-5; 4,4-Dimethyl-3,5,8-Trioxabicyclo[5.1.0]Octane

相似化合物

4416-85-7 1607-37-0 5754-34-7

上下游产品

6-Bromo-2,2-Dimethyl-1,3-Dioxepan-5-Ol

钆布醇中间体置于disodium Hydrogenphosphate,间氯过氧苯甲酸体系中,用 二氯甲烷 作为反应溶剂,化学反应 18.0H,以85%的收率获得产物4,4-二甲基-3,5,8-三氧杂双环[5,1,0]辛烷
参考文献:2,3-二氟丁烷-1,4-二醇非对映异构体的合成.
标题:2,3-二氟丁烷-1,4-二醇非对映异构体的合成.
摘要:含有手性氟取代基的氟化结构单元的非对映选择性合成是令人感兴趣的.在这里,我们描述了抗 2,3-二氟丁烷-1,4-二醇的合成以及相应的顺式非对映体的合成中的优化工作.这两个目标都是使用环氧化物开放策略合成的.
DOI:10.3762/bjoc.13.280

专利信息

专利号:US-11091449-B2
优先权日:2017-08-29
标题:Gadobutrol intermediate and gadobutrol production method using same
发明人：LEE JAE YOUNG; LEE JONG SOO; KANG BYUNG KYU; LEE SANG OH; LEE BYOUONG WOO; YUN DAE MYOUNG; BANG JAE HUN; KYUNG SEOK CHOI
权利人:ENZYCHEM LIFESCIENCES CORP
摘要:Disclosed are: an intermediate capable of high-purity synthesis of gadobutrol which can be used as an MRI contrast agent; and a gadobutrol production method using same. The gadobutrol intermediate is represented by Chemical Formula 2 in the specification.

专利号:US-4341756-A
优先权日:1980-01-31
标 题 :Novel amino-dioxepane intermediates for the synthesis of new non-ionic contrast media
发明人：SOVAK MILOS; RANGANATHAN RAMACHANDRAN
权利人:UNIV CALIFORNIA
摘要:Novel intermediates for non-ionic polyiodo amino-substituted benzenepolyamides having polyol substituents on the amide nitrogens are provided which are 5-amino-6-hydroxy-1,3-dioxepanes. The compounds provide an economic and efficient route to novel contrast media having excellent chemical and physiological properties. n Also provided are methods for preparing the subject compounds.

专利号:US-4439613-A
优先权日:1980-04-17
标 题:Novel amino-dioxepane intermediates for the synthesis of new non-ionic contrast media
发明人：SOVAK MILOS; RANGANATHAN RAMACHANDRAN
权利人:UNIV CALIFORNIA
摘要:Novel intermediates for non-ionic polyiodo amino-substituted benzenepolyamides having polyol substituents on the amide nitrogens are provided which are 5-amino-6-hydroxy-1,3-dioxepanes. The compounds provide an economic and efficient route to novel contrast media having excellent chemical and physiological properties. Also provided are methods for preparing the subject compounds.