CAS: 5908-99-6; Atropine Sulfate Monohydrate

该化合物是一种晶状的碱性碱性衍生物,通常用于制药和研究应用,其化学配方(C17H23NO3)2 /H2SO4 /H2O,反映其单水合物形式,确保水溶液的稳定性和一致性溶解性.它作为一种有竞争力的肌肉性乙酰胆碱受体受体抗体对抗剂,在抑制寄生性...

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CAS号529-64-6 托品酸 | CAS号500-55-0 阿朴阿托品

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    专利信息


    专利号:US-4311645-A
    优先权日:1980-03-24
    标 题 :Synthesis of SRS-active compounds
    发明人：ROSENBERGER MICHAEL
    权利人:HOFFMANN LA ROCHE
    摘要:A chemical synthesis of an SRS-A active compound from the reaction product of 1-halo-2-octyne and the ether of 2-penten-4-yn-1-ol including intermediates in the synthesis, some of which being antagonists of SRS-A useful for treating allergic reactions.

    专利号:US-2008280855-A1
    优先权日:2005-06-22
    标 题 :Process For the Production of Intermediates For the Preparation of Tricyclic Benzimidazoles
    发明人：CHIESA MARIA VITTORIA; PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; SIMON WOLFGANG-ALEXANDER; POSTIUS STEFAN; KROMER WOLFGANG; ZANOTTI-GEROSA ANTONIO
    权利人:NYCOMED GMBH
    摘要:The invention relates to a process for the synthesis of compounds of the formula 1-a and compounds of the formula 1-b. n n n n n n n n n n The compounds of the formula 1-a and the compounds of the formula 1-b, in which the substituents R1, R2, R3, and Ar have the meanings indicated in the description, are valuable intermediates for the preparation of pharmaceutically active compounds.

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    主要参考文献


    1: Addo RT, Yeboah KG, Siwale RC, Siddig A, Jones A, Ubale RV, Akande J, Nettey H, Patel NJ, Addo E, D'Souza MJ. Formulation and characterization of atropine sulfate in albumin-chitosan microparticles for in vivo ocular drug delivery. J Pharm Sci. 2015 May;104(5):1677-90. doi: 10.1002/jps.24380. Epub 2015 Feb 4. pii: bcr2014207596. doi: 10.1136/bcr-2014-207596. doi: 10.1016/j.talanta.2014.07.082. Epub 2014 Aug 12. doi: 10.1111/vop.12138. Epub 2014 Jan 16. Chinese. doi: 10.1016/j.jpba.2013.10.036. Epub 2013 Nov 7.
    8: Byadagi KS, Nandibewoor ST, Chimatadar SA. Catalytic activity of ruthenium(III) on the oxidation of an anticholinergic drug-atropine sulfate monohydrate by copper(III) periodate complex in aqueous alkaline medium - decarboxylation and free radical mechanism. Acta Chim Slov. 2013;60(3):617-27. doi: 10.2460/ajvr.74.11.1404. doi: 10.3109/08958378.2012.691912. doi: 10.1089/jamp.2011.0948. Epub 2012 Jun 12.
    12: Wu H, Fan Z. Mn-doped ZnS quantum dots for the room-temperature phosphorescence detection of raceanisodamine hydrochloride and atropine sulfate in biological fluids. Spectrochim Acta A Mol Biomol Spectrosc. 2012 May;90:131-4. doi: 10.1016/j.saa.2012.01.041. Epub 2012 Jan 27. doi: 10.3109/08958378.2011.554458. Epub 2011 Jan 8. doi: 10.1016/j.ajem.2008.10.025. doi: 10.1088/1752-7155/3/4/047003. Epub 2009 Nov 27. doi: 10.1089/acm.2008.0614. doi: 10.1111/j.1346-8138.2009.00602.x.

    合成参考文献


    摘要:Schafer, E. W., Jr., and W. A. Bowles Jr. 2004. Toxicity, Repellency of Phytotoxicity of 979 Chemicals to Birds, Mammals and Plants. Research Report No. 04-01. National Wildlife Research Center, Fort Collins, Colorado. 118 pp. https://www.aphis.usda.gov/ws/nwrc/chem-effects-db/U_schafer041_2004.pdf
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