CAS: 700381-18-6; 2-(Bromomethyl)-4-Fluoro-1-Methoxybenzene

上下游产品

CAS号426831-32-5 5-氟-2-甲氧基苄醇 | CAS号19415-51-1 5-氟-2-甲氧基苯甲醛 | CAS号709025-81-0 Benzeneacetonit...

5-氟-2-甲氧基苯甲醛置于甲醇,Sodium Tetrahydroborate,三溴化磷体系中,用 乙醚 作为反应溶剂,化学反应 3.17H,反应生成 5-氟-2-甲氧基溴苄
参考文献:2-卤代-N-Ms-芳基胺与苄基卤化物/磺酸盐的钯催化级联反应合成菲啶
标题:2-卤代-N-Ms-芳基胺与苄基卤化物/磺酸盐的钯催化级联反应合成菲啶
摘要:已经描述了容易获得的 2-卤代-N-Ms-芳基胺(ms = 甲磺酰基)和苄基卤化物/磺酸盐之间的有效钯催化亲核取代/c-H 活化/芳构化级联反应.以一锅法以中等至高产率 (37-86%) 合成了多种菲啶.值得注意的是,该方法为菲啶的合成提供了一种直接,简便的方法.通过成功进行克级制备进一步证实了实用性.
DOI:10.1002/ejoc.201601608

专利信息

专利号:US-12410142-B2
优先权日:2017-04-07
标 题:Substituted imidazole salt compounds, preparation method thereof, pharmaceutical composition thereof and application thereof
发明人：DENG XIANMING; LIN SHENGCAI; ZHANG CHENSONG
权利人:XIAMEN VIVOHEALTHS TECH CO LTD
摘要:Disclosed in the invention are a type of compounds having aldolase selective inhibitory activity, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for inhibiting triglyceride and cholesterol synthesis, for reducing fatty acid synthesis, for preventing and/or treating obesity and type II diabetes, for preventing and/or treating tumor, for preventing and/or treating Parkinson's disease, for preventing and/or treating Alzheimer's disease or for prolonging the lifespan of mammals: