CAS: 81246-82-4; N-(9-((2R,3R,4S,5R)-5-((Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Methyl)-3,4-Dihydroxytetrahydrofuran-2-yl)-9H-Purin-6-yl)Benzamide

该化合物是一个经过修改的核素侧面,其特点是在5'氢氧基座的N6位置上有一个苯化物基和一个5'羟基位置的保护组,该化合物主要用于核酸化学领域,特别是用于合成核素核素基体.DMT组是一个保护性动物,防止在合成过程中出现不想要的反应,允许在特定阶段有选择地取消保护.苯并聚物组的存在加强了核素底部的稳定性和溶性,使之适合各种生物化学应用.此外,纯核素的复合物特征,包括参与氢结合和基配对的能力,这对于其在核酸结构中的作用至关重要.总体而言,5'-O-4,4,4'-Dimetoxoxritytyl)-N6-苯甲酸丁基丁基苯基苯丙基丁是经过修改后RNA和DNA序列合成的重要建筑块,有助于分子生物学和治疗生物学的发展.

英文名称N-(9-((2R,3R,4S,5R)-5-((Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Methyl)-3,4-Dihydroxytetrahydrofuran-2-yl)-9H-Purin-6-yl)Benzamide
中文名称5''-O-(4,4''-二甲氧基三苯甲基)-N6-苯甲酰基腺苷
IUPAC名称N-(9-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide
其它别名N6-Benzoyl-5'-O-Dmt-Adenosine; 5'-Dmt-Bz-Ra; 5'-O-Dmt-N6-Bz Adenosine; N6-Benzoyl-5'-O-(4,4'-Dimethoxytrityl)Adenosine; N-Benzoyl-5'-O-[bis(4-Methoxyphenyl)Phenylmethyl]Adenosine; N6-Bz-Dmt-Ar; 5'-O-Dimethoxytrityl-N6-Benzoyl Adenosine
CAS编号81246-82-4
MFCD编号:MFCD00797466
分子式:C38H35N5O7
分子量:673.71
产品CID: 1806448
产品分类有机原料→生命科学→核苷&核苷酸→其他保护性核苷

相似结构搜索
InChIKey: QPHBEJADZCSKCY-UHFFFAOYSA-N
InChI=1S/C38H35N5O7/c1-47-28-17-13-26(14-18-28)38(25-11-7-4-8-12-25,27-15-19-29(48-2)20-16-27)49-21-30-32(44)33(45)37(50-30)43-23-41-31-34(3…
计算化学: 氢键受体数11.0氢键供体数3.0可旋转键数11.0

相似化合物

81256-88-4 81265-93-2 110764-72-2

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险品标志Xi
安全声明H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body

上下游产品

4,4'-dimethoxytrityl chloride N-benzoyladenosine N-benzoyladenine benzoyl chloride 6-benzoyl-5'-O-dimethoxytrityladenosine 2',3'-cyclic phosphoromorpholiditeN6-benzoyl-5'-O-dimethoxytrityladenosine 2',3'-cyclic phosphoromorpholidite Carbonic acid (2R,3R,4R,5R)-2-(6-benzoylamino-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-3-yl ester tert-butyl ester 4-Oxo-pentanoic acid (2R,3S,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-3-yl ester 6-N-Benzoyl-5'-O-(4,4'-dimethoxy)trityladenosine-2',3'-bis(O,O-di(2-cyanoethyl) phosphate)

合成工艺路线路线简述

4546-55-8 + 40615-36-9 = 81246-82-4
反应条件:1.1 Solvents: Pyridine; 8 H,Rt
标题:Preparation Of Acyclic Purine Nucleoside Derivatives
参考文献:China]

4005-49-6 = 81246-82-4
反应条件:1.1 Reagents: Sodium Hydride Solvents: Dimethylformamide; 15 Min,Rt1.2 12 H,Rt1.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 7,Rt
标题:Synthesis Of Nucleosides Through Direct Glycosylation Of Nucleobases With 5-O-Mono-Protected Or 5-Modified Ribose: Improved Protocol,Scope,And Mechanism
作者:Downey,A. Michael; Pohl,Radek; Roithova,Jana; Hocek,Michal
参考文献:Chemistry - A European Journal 日期:2017 卷标:23(16) 页码:3910-3917]

4546-55-8 + 40615-36-9 = 81246-82-4
反应条件:1.1 Solvents: Pyridine; Overnight,Rt
标题:A Conformational Restriction Strategy For The Control Of Crispr/cas Gene Editing With Photoactivatable Guide Rnas
作者:Sun,Ying-Jie; Chen,Wen-Da; Liu,Ji; Li,Jun-Jin; Zhang,Yu; Et Al
参考文献:Angewandte Chemie 日期:2023 卷标:62(5)]

4546-55-8 + 40615-36-9 = 81246-82-4
反应条件:1.1 Solvents: Dichloromethane
标题:Solid-Phase Synthesis And High-Resolution Nmr Studies Of Two Synthetic Double-Helical Rna Dodecamers: R(Cgcgaauucgcg) And R(Cgcguauacgcg)
作者:Chou,Shan Ho; Flynn,Peter; Reid,Brian
参考文献:Biochemistry 日期:1989 卷标:28(6) 页码:2422-35]

4546-55-8 + 40615-36-9 = 81246-82-4
反应条件:1.1 Solvents: Pyridine; 1 H,Rt1.2 Solvents: Ethanol; Rt
标题:Synthesis And Structural Characterization Of Diastereomeric Isomers Of Rna Trimer Adenylyl(3'-5')Adenylyl(3'-5')Adenosine
作者:Urata,Hidehito; Hara,Hisafumi; Hirata,Yoshihiro; Ohmoto,Norihiko; Akagi,Masao
参考文献:Tetrahedron: Asymmetry 日期:2005 卷标:16(17) 页码:2908-2917]

4546-55-8 + 40615-36-9 = 81246-82-4
反应条件:1.1 Catalysts: 4-(Dimethylamino)Pyridine Solvents: Pyridine; 0 °C; 16 H,Rt1.2 Reagents: Methanol; Rt
标题:Discovery Of Iacs-8803 And Iacs-8779,Potent Agonists Of Stimulator Of Interferon Genes (Sting) With Robust Systemic Antitumor Efficacy
作者:Ager,Casey R.; Zhang,Huaping; Wei,Zhanlei; Jones,Philip; Curran,Michael A.; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2019 卷标:29(20)]

4546-55-8 + 40615-36-9 = 81246-82-4
反应条件:1.1 Catalysts: Pyridine
标题:Chemical Synthesis Of Oligonucleotides. 3: Synthesis And Characterization Of N,O-Protected Ribophosphoesters For Applications In Rna Synthesis
作者:Gopalakrishnan,Vidhya; Ganesh,K. N.
参考文献:Proceedings - Indian Academy Of Sciences 日期:1989 卷标:101(5) 页码:401-13

专利信息

专利号:US-2018355369-A1
优先权日:2015-07-02
标题:Method for Increasing Plant Stress Tolerance and Seed Dormancy
发明人：POGSON BARRY JAMES; ESTAVILLO GONZALO MARTIN; CHAN KAI XUN; PHUA SU YIN; CRISP PETER ALEXANDER
权利人:UNIV AUSTRALIAN NATIONAL
摘要:The present invention provides a method for increasing the levels of 3â€²-phosphoadenosine-5â€²-phosphate (PAP) or a derivative or analogue thereof in cells of said plant compared to an untreated or wild-type plant grown under the same stress conditions. The methods may comprise administration to the plant and/or the soil it is growing in of: PAP or a derivative or analogue thereof, a substance that enhances or promotes synthesis or accumulation of PAP or said derivative or analogue thereof; or a substance that inhibits or compromises an activity metabolising or removing PAP or said derivative or analogue thereof. Alternatively, the methods may comprise genetic modification of cells of said plant which modifications allow for increased accumulation of PAP or a derivative or analogue thereof in cells of said plant (or in seeds thereof) at least under stress conditions compared to a wild-type plant. The methods find particular application in increasing the tolerance of plants to abiotic stress conditions, which may be selected from increased salinity, increased sodium levels, drought, light stress and pH stress. The present invention also provides a method for extending the dormancy of a seed, as compared to an untreated seed, said method comprising accumulating in cells within said seed an increased level of PAP or a derivative or analogue thereof compared to an untreated or wild-type seed.