CAS: 105-33-9; 4-Chloro-3-Hydroxybutanenitrile

相似化合物

127913-44-4 84367-31-7 727382-14-1

上下游产品

CAS号151-50-8 氰化钾 | CAS号106-89-8 环氧氯丙烷 | CAS号143-33-9 氰化钠 | CAS号74-90-8 氢氰酸 | CAS号75-86-5 丙酮氰醇 | CAS号96-23-1 1,3-二氯丙醇 | CAS号7677-24-9 三甲基氰硅烷 | CAS号109-75-1 3-丁烯腈 | CAS号81091-27-2 4-chloro-3-trim... | CAS号18933-33-0 1-Propanaminium... | CAS号29331-43-9 (1-chloro-3-cya... | CAS号13880-89-2 3-羟基戊二腈 | CAS号10479-81-9 (2E)-4-hydroxyb... | CAS号19060-14-1 γ-Cyano-allylalkohol | CAS号74923-98-1 (R)-3,4-dihydro... | CAS号127913-44-4 (S)-4-氯-3-羟基丁腈 | CAS号34362-21-5 3,4-dichlorobut... | CAS号10488-68-3 4-氯-3-羟基丁酸甲酯 | CAS号2788-28-5 L-卡内腈

烯丙基腈置于次氯酸体系中,化学反应生成4-氯-3-羟基丁腈
参考文献:Vessiere,R.; Chartier,H.,Bulletin De La Societe Chimique De France,1963,P. 200
标题:Vessiere,R.; Chartier,H.,Bulletin De La Societe Chimique De France,1963,P. 200

专利信息

专利号:US-6384228-B2
优先权日:1998-05-26
标题 :Method for synthesis of halopyridyl-azacyclopentane derivative and intermediate thereof
发明人：NODE MANABU; NAKAMURA DAISAKU; FUJIWARA TOSHIO; ICHIHASHI SHOGO
权利人:NIHON MEDIPHYSICS CO LTD
摘要:The present invention relates to a method for synthesis of an optically active halopyridyl-azacyclo-pentane derivative and the intermediate thereof which comprises preparing an optically active allene-1,3-dicarboxylic acid ester derivative from an optically active acetonedicarboxylic acid ester derivative and then proceeding through a 7-azabicyclo[2.2.1]heptane derivative to obtain the objective product.

专利号:WO-2025087822-A1
优先权日:2023-10-23
标 题 :New process for the preparation of (3r)-fluoropyrrolidine hydrochloride
发明人：ENGL PASCAL STEPHAN; HILDBRAND STEFAN; MOESSNER CHRISTIAN; STOECKLI MARKUS; STUTZ ALFRED
权利人:HOFFMANN LA ROCHE; HOFFMANN LA ROCHE
摘要:The present invention relates to a new process for the preparation of (3R)-3-fluoropyrrolidine hydrochloride or an acceptable salts thereof via a N-Boc-(3S)-3-hydroxypyrrolidine intermediate. The process is suitable for the synthesis of N-Boc-(3S)-3- hydroxypyrrolidine at technical scale in high, not less than 99.85%-a/a optical purity and a purity of not less than 99.8%-a/a. The high quality N-Boc-(3S)-3-hydroxypyrrolidine can be converted to (3R)-3-fluoropyrrolidine hydrochloride exhibiting an optical purity of not less than 99.95%-a/a and a purity of not less than 99.5%-a/a thus making it a suitable intermediate for manufacturing of pharmaceutical active compounds.

专利号:US-8802811-B2
优先权日:2006-12-12
标 题:Process for the synthesis of 3-hydroxyglutaronitrile
发明人：CIRAKOVIC JELENA
权利人:CIRAKOVIC JELENA; DU PONT
摘要:A high yield and high productivity processes for preparing 3-hydroxyglutaronitrile by reacting an epihalohydrin or a 4-halo-3-hydroxy-butanenitrile, or analogous compound containing a different leaving group, with cyanide (CN—) in the presence of water and an ionic liquid. The use of an ionic liquid as a cosolvent with water results in increased productivity and selectivity.

专利号:WO-2005030747-A1
优先权日:2003-09-29
标 题:A process for the synthesis of 3-hydroxy-gamma-butyrolactone
发明人：SHIN HYUN-IK; CHANG JAY-HYOK; WOO YOUNG-MIN; KIM YOUNG-SOOK
权利人:LG LIFE SCIENCES LTD; SHIN HYUN-IK; CHANG JAY-HYOK; WOO YOUNG-MIN; KIM YOUNG-SOOK
摘要:The present invention relates to a process for preparing pure 3-hydroxy-Ïœ-butyrolactone by hydrolyzing 4-chloro-3-hydroxy-butyronitrile in the presence of acids and conducting cyclization reaction under slightly basic condition.

专利号:US-2011130540-A1
优先权日:2007-08-17
标 题:Processes for the synthesis of 3-hydroxyglutaronitrile
发明人：CIRAKOVIC JELENA
权利人:DU PONT
摘要:There are disclosed high yield and high productivity processes for preparing 3-hydroxyglutaronitrile by reacting allyl cyanide epoxide with a basic aqueous solution of a cyanide source.

专利号:WO-2014203045-A1
优先权日:2013-06-20
标 题:A novel, green and cost effective process for synthesis of tert-butyl (3r,5s)-6-oxo-3,5-dihydroxy-3,5-o-isopropylidene-hexanoate
发明人：ROY BHAIRABNATH; SINGH GIRIJ PAL; LATHI PIYUSH SURESH; AGRAWAL MANOJ KUNJABIHARI; MITRA RANGAN; TRIVEDI ANURAG; PISE VIJAY SADASHIV; RUPANWAR MANOJ
权利人:LUPIN LTD
摘要:The present invention provides a process of preparation of an intermediate useful for the preparation of statins more particularly the present invention relates to an eco-friendly and cost effective process for the preparation of tert -butyl (3R,5S)-6-oxo-3,5-dihydroxy- 3,5-O-isopropylidene-hexanoate [I].