CAS: 1616342-45-0; (2R,5S,13Ar)-8-Methoxy-7,9-Dioxo-2,3,4,5,7,9,13,13A-Octahydro-2,5-Methanopyrido[1',2':4,5]Pyrazino[2,1-B][1,3]Oxazepine-10-Carboxylic Acid

英文名称(2R,5S,13Ar)-8-Methoxy-7,9-Dioxo-2,3,4,5,7,9,13,13A-Octahydro-2,5-Methanopyrido[1',2':4,5]Pyrazino[2,1-B][1,3]Oxazepine-10-Carboxylic Acid
中文名称(2R,5S,13AR)-8-甲氧基-7,9-二氧代-2,3,4,5,7,9,13,13A-八氢-2,5-甲桥吡啶并[1',2':4,5]吡嗪并[2,1-B][1,3] 氧氮杂环庚烷-10-羧酸
IUPAC名称(2R,5S,13aR)-8-methoxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxylic acid
CAS编号1616342-45-0
MFCD编号:MFCD31730918
FDA UNII编号:RD7MNM79RD
分子式:C15H16N2O6
分子量:320.3
产品CID: 816136
产品分类有机原料 → 有机杂环化合物 → 吡啶及其衍生物

相似结构搜索
InChIKey: GARGTTZRFPGJSI-QXFUBDJGSA-N
InChI=1S/C15H16N2O6/c1-22-13-11-14(19)17-7-2-3-8(4-7)23-10(17)6-16(11)5-9(12(13)18)15(20)21/h5,7-8,10H,2-4,6H2,1H3,(H,20,21)/t7-,8+,10+/m0/s…
计算化学: 氢键受体数7.0氢键供体数1.0可旋转键数2.0

MSDS等安全信息

上下游产品

Dimethyl 1-(2,2-Dimethoxyethyl)-3-Methoxy-4-Oxo-1,4-Dihydropyridine-2,5-Dicarboxylate
Dolutegravir中间体 1-(2,2-Dimethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-Oxo-1,4-Dihydropyridine-3-Carboxylic Acid 1335210-23-5
1-(2,2-Dihydroxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-Oxo-1,4-Dihydropyridine-3-Carboxylic Acid 1616340-75-0

合成工艺路线路线简述

合成目标产物 (2R,5S,13Ar)-8-Methoxy-7,9-Dioxo-2,3,4,5,7,9,13,13A-Octahydro-2,5-Methanopyrido[1',2':4,5]Pyrazino[2,1-B][1,3]Oxazepine-10-Carboxylic Acid 主要起始原料 (1R,3S)-3-Aminocyclopentanol Hydrochloride And 2,5-Pyridinedicarboxylic Acid, 1-(2,2-Dihydroxyethyl)-1,4-Dihydro-3-Methoxy-4-Oxo-, 2-Methyl Ester
(文献来源)合成步骤主要原料 (1R,3S)-3-Aminocyclopentanol Hydrochloride 和 2,5-Pyridinedicarboxylic Acid, 1-(2,2-Dihydroxyethyl)-1,4-Dihydro-3-Methoxy-4-Oxo-, 2-Methyl Ester

4-甲氧基乙酰乙酸甲酯置于甲烷磺酸,水,Sodium Methylate,碳酸氢钠,溶剂黄146,Sodium Hydroxide体系中,用甲醇用作溶剂,化学反应生成(2R,5S,13Ar)-8-甲氧基-7,9-二氧代-2,3,4,5,7,9,13,13A-八氢-2,5-甲桥吡啶并[1',2':4,5]吡嗪并[2,1-B][1,3]氧氮杂环庚烷-10-羧酸
参考文献: Continues Flow Process For The Preparation Of Active Pharmaceutical Ingredients-Polycyclic Carbamoyl Pyridone Derivatives And Intermediates Thereof[fr] Procédé à Flux Continu Pour La Préparation De Dérivés De Carbamoylpyridone Polycycliques à Ingrédients Pharmaceutiquement Actifs Et Intermédiaires De Ceux-Ci
标题: Continues Flow Process For The Preparation Of Active Pharmaceutical Ingredients-Polycyclic Carbamoyl Pyridone Derivatives And Intermediates Thereof[fr] Procédé à Flux Continu Pour La Préparation De Dérivés De Carbamoylpyridone Polycycliques à Ingrédients Pharmaceutiquement Actifs Et Intermédiaires De Ceux-Ci
摘要:本发明公开了用于制备多环氨基吡啶酮衍生物及其中间体的连续流程.具体地,本发明公开了一种制备中间体的方法.公式(v).