CAS: 183802-98-4; 5-Bromo-2-Chlorophenol

上下游产品

CAS号16817-43-9 5-溴-2-氯苯甲醚 | CAS号18282-59-2 3,4-二氯溴苯 | CAS号124-41-4 甲醇钠 | CAS号876487-15-9 2,3,4-tribromo-... | CAS号71-43-2 苯 | CAS号60811-17-8 2-氯-5-溴苯胺 | CAS号95-76-1 3,4-二氯苯胺 | CAS号7446-70-0 氯化铝 | CAS号915201-06-8 3-羟基-4-氯苯硼酸 | CAS号16817-43-9 5-溴-2-氯苯甲醚 | CAS号1198422-80-8 甲基4-氯-3-羟基-[1,1... | CAS号85117-86-8 3-bromo-2,4,6-t... | CAS号900174-61-0 4-溴-1-氯-2-乙氧基苯

5-溴-2-氯苯甲醚置于三溴化硼,Potassium Carbonate,盐酸体系中,用 二氯甲烷,水 用作溶剂,化学反应 14.0H,以96%的收率获得5-溴-2-氯苯酚
参考文献:D-Xylopyranosyl-Phenyl-Substituted Cycles,Medicaments Containing Such Compounds,Their Use And Process For Their Manufacture
标题:D-Xylopyranosyl-Phenyl-Substituted Cycles,Medicaments Containing Such Compounds,Their Use And Process For Their Manufacture
摘要:通式i的d-葡萄糖吡喃基苯取代环,其中基团r1至r6,Z,Cy以及r7A,R7B,R7C,R7D如权利要求1所定义,在钠依赖型葡萄糖协同转运蛋白sglt上具有抑制作用.本发明还涉及用于治疗代谢紊乱的药物组合物.

专利信息

专利号:US-9994558-B2
优先权日:2013-09-20
标题 :Multicyclic compounds and methods of using same
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to compounds represented by Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders (e.g., PAK-mediated, for example, PAK4-mediated, diseases and disorders).

专利号:US-8063224-B2
优先权日:2006-12-01
标 题 :Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：LACHANCE NICOLAS; LI CHUN SING; LECLERC JEAN-PHILIPPE; RAMTOHUL YEEMAN K
权利人:LACHANCE NICOLAS; LI CHUN SING; LECLERC JEAN-PHILIPPE; RAMTOHUL YEEMAN K; MERCK CANADA INC
摘要:Azacycloalkane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

专利号:US-7582633-B2
优先权日:2007-01-26
标题:Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：LEBLANC YVES; POWELL DAVID; RAMTOHUL YEEMAN K; LEGER SERGE
权利人:MERCK FROSST CANADA L L C
摘要:Azacycloalkane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

专利号:US-2010249192-A1
优先权日:2007-12-11
标 题 :Novel heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：LI CHUN SING; RAMTOHUL YEEMAN K; LECLERC JEAN-PHILIPPE
权利人:MERCK FROSST CANADA LTD
摘要:Heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; Metabolic Syndrome; insulin resistance; cancer; liver steatosis; and non-alcoholic steatohepatitis. n HetAr − W − X − Ar  (I)

专利号:US-11325903-B2
优先权日:2016-11-30
标 题:Substituted pyrazole compounds and methods of using them for treatment of hyperproliferative diseases
发明人：SIDDIQUI M ARSHAD; CIBLAT STEPHANE; DERY MARTIN; CONSTANTINEAU-FORGET LEA; GRAND-MAITRE CHANTAL; BRUNEAU-LATOUR NICOLAS; SHIPPS GERALD W; COOPER ALAN B; OZA VIBHA; KOSTURA MATTHEW J; LUTHER MICHAEL; LEVINE JEDD
权利人:BANTAM PHARMACEUTICAL LLC
摘要:Disclosed are compounds useful, for example, in methods of treating hyperproliferative disorders such as cancer, methods of arresting the cell cycle in cancer cells, methods of inhibiting glutathione synthesis in cancer cells, and associated compounds for use and uses in medicaments. In certain embodiments, the methods, uses and compounds are provided with reference to compounds of the structural formulae (Ia), (Ib), (Ic), (Id) and (Ie), in which R 1 , L 1 , L 2 , Q, L 3 , R 3 , L 4 , R 4 , L 5 , and R 5 are as described herein. In certain embodiments, compounds disclosed herein are especially active against cancers having a mutant KRAS gene.

专利号:US-9938258-B2
优先权日:2012-11-29
标 题:Substituted 2,3-dihydrobenzofuranyl compounds and uses thereof
发明人：BALOGLU ERKAN; SHECHTER SHARON; SHACHAM SHARON; MCCAULEY DILARA; SENAPEDIS WILLIAM; GOLAN GALI; KALID ORI
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to substituted 2,3-dihydrobenzofuranyl compounds, and more particularly to a compound represented by Structural Formula I: n nor a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.