专利号:US-9885035-B2 优先权日:2002-10-30 标 题 :Method for the synthesis of a bifunctional complex 发明人:FRANCH THOMAS; GOULIAEV ALEX HAAHR 权利人:NUEVOLUTION AS 摘要:Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes.
专利号:US-9574189-B2 优先权日:2005-12-01 标题:Enzymatic encoding methods for efficient synthesis of large libraries 发明人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK 权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS 摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).
专利号:EP-0051234-B1 优先权日:1980-10-31 标题:A process for the production of a 2-azetidinone derivative 摘要:A new and efficient process of producing a 2-azetidinone derivative is provided, which comprises cyclizing a beta -amino acid by treating with triphenylphosphine and a heterocyclic disulfide in the presence of an alkylnitrile. The 2-azetidinone derivatives produced are useful as starting compound for synthesis of beta -lactam group antibiotics such as thienamycin and nocardicin.
专利号:US-11225655-B2 优先权日:2010-04-16 标题:Bi-functional complexes and methods for making and using such complexes 发明人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK 权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS 摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.
专利号:US-12018097-B2 优先权日:2017-06-09 标题 :Non-chromatographic purification of macrocyclic peptides by a resin catch and release 发明人:CREECH GARDNER S; KHEIRABADI MAHBOUBEH; EASTGATE MARTIN D; NIRSCHL DAVID S; CARTER PERCY H 权利人:BRISTOL MYERS SQUIBB CO 摘要:The disclosure is directed to the synthesis and improved methods for purifying macrocyclic peptides produced by solid phase peptide synthesis. The synthesized peptide is capped with an alkyne-functionalized or azide-functionalized compound of formula (I):prior to cleavage of the peptide from the solid phase support.
专利号:US-2019136227-A1 优先权日:2002-10-30 标题:Method for the synthesis of a bifunctional complex
参考标题:Synthesis Of Sulfonimidamides From Sulfenamides Via An Alkoxy‐amino‐λ 6 ‐sulfanenitrile Intermediate 作者:Edward L. Briggs,Arianna Tota,Marco Colella,Leonardo Degennaro,Renzo Luisi,James A. Bull |发布日期:2019.10 摘要:Few Operationally Simple Methods For Their Preparation. Here, The Synthesis Of Nh-Sulfonimidamides Is Achieved Directly From Sulfenamides, Themselves Readily Formed In One Step From Amines And Disulfides. A Highly Chemoselective And One-Pot Nh And O Transfer Is Developed, Mediated By Phio In Iproh, Using Ammonium Carbamate As The Nh Source, And In The Presence Of 1 Equivalent Of Acetic Acid. A Wide
合成参考文献
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