CAS: 2859-78-1; 4-Bromo-1,2-Dimethoxybenzene

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CAS号91-16-7 1,2-二甲氧基苯 | CAS号39416-48-3 三溴化吡啶鎓 | CAS号66037-04-5 acetic acid,5-b... | CAS号77-78-1 硫酸二甲酯 | CAS号7368-78-7 4-溴-2-甲氧基苯酚 | CAS号90-05-1 愈创木酚 | CAS号77-48-5 二溴海因 | CAS号37942-01-1 5-溴-2-甲氧基苯酚 | CAS号74-88-4 碘甲烷 | CAS号506-68-3 溴化氰 | CAS号4302-52-7 3,4-二甲氧基苯炔 | CAS号35249-62-8 2-溴-4,5-二甲氧基苯丙腈 | CAS号51072-66-3 1-溴-4,5-二甲氧基-2-硝基苯 | CAS号37895-73-1 4,5-二溴-1,2-二甲氧基苯 | CAS号4687-37-0 3,4-二甲氧基苯甲酰乙酸乙酯 | CAS号398-62-9 4-氟-1,2-二甲氧基苯 | CAS号91-16-7 1,2-二甲氧基苯 | CAS号365564-10-9 3,4-二甲氧基苯硼酸频哪醇酯 | CAS号32767-70-7 2-(pentyloxy)te...

邻苯二甲醚置于1,3-二溴-5,5-二甲基海因,Methyl 2-Pentyl-Indole-3-Carboxylate体系中,用 正庚烷 用作溶剂,化学反应 12.0H,以90%的收率获得4-溴黎芦醚
参考文献:对环境有利的吲哚催化的硫代芳烃和其他芳族化合物的位置选择性卤化
标题:对环境有利的吲哚催化的硫代芳烃和其他芳族化合物的位置选择性卤化
摘要:卤代芳族化合物是许多医药,农业和化学产品的核心,但它们通常是在苛刻条件下在非绿色氯化溶剂中使用亲电子卤化反应制备的.另一个问题是硫代芳烃的芳族卤化,因为它们容易发生氧化副反应.在本文中,我们报告了使用吲哚催化方案的芳香族化合物的对环境无害的亲电子溴化反应,该方法适用于包括硫代芳烃在内的各种底物.
Doi:10.1039/c8Gc02415D

专利信息

专利号:US-8779122-B2
优先权日:2012-11-08
标 题:Process for the synthesis of (2E)-3-(3,4-dimethoxyphenyl)prop-2-enenitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
发明人：CARRANZA MARIA DEL PILAR; GARCIA ARANDA MARIA ISABEL; GONZALEZ JOSÉ LORENZO; SANCHEZ FRÉDÉRIC
权利人:SERVIER LAB
摘要:Process for the synthesis of the compound of formula (I): n nApplication in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.

专利号:US-8604213-B2
优先权日:2008-10-21
标 题 :Fluorination of aromatic ring systems
发明人：DIMAGNO STEPHEN
权利人:DIMAGNO STEPHEN; NUTECH VENTURES
摘要:This disclosure relates to reagents and methods useful in the synthesis of aryl fluorides, for example, in the preparation of 18 F labeled radiotracers. The reagents and methods provided herein may be used to access a broad range of compounds, including aromatic compounds, heteroaromatic compounds, amino acids, nucleotides, and synthetic compounds.

专利号:US-8530689-B2
优先权日:2008-05-05
标 题 :Processes for the preparation of biphenyl compounds
发明人：PERCEC VIRGIL; ROSEN BRAD MATTHEW; WILSON DANIELA A; WILSON CHRISTOPHER J
权利人:PERCEC VIRGIL; ROSEN BRAD MATTHEW; WILSON DANIELA A; WILSON CHRISTOPHER J; UNIV PENNSYLVANIA
摘要:The invention concerns processes for the synthesis of a compound of the formula: wherein: R 1 and R 2 are each, independently, C 1 -C 12 alkyl, CO 2 R 3 , OR 4 , R 5 (OR 6 ), or C 6 -C 18 aryl; R 3 -R 6 are each, independently, C 1 -C 12 alkyl or C 6 -C 12 aryl; and n and m are each, independently, O or an integer from 1-5; said process comprising:—contacting a compound of the formula H0-R 7 -0H with BH 3 and a compound of the formula in the presence of a nickel-containing catalyst to produce a first product, where R 7 is a C 2 -C 12 hydrocarbon group and X is a halogen, OMs or OTs;—contacting the first product in situ with a compound of the formula: in the presence of a nickel-containing catalyst to produce a compound of formula I, where Z is a halogen.

专利号:US-7884125-B2
优先权日:2008-04-30
标 题:Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues
发明人：STEVENS CHRISTIAN; HEUGEBAERT THOMAS
权利人:UNIV GENT
摘要:The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invention also relates to certain intermediates for producing such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as a synthetic method for producing such intermediates. The present invention also relates to pharmaceutical compositions comprising such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as their use as medicaments for the treatment of diseases mediated by a Nicotinic Acetylcholine Receptor or a receptor being a member of the Neurotransmitter-gated Ion Channel Superfamily, such as pain, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy and nicotine addiction.

专利号:US-6465693-B2
优先权日:1998-02-26
标 题 :Metal-catalyzed arylations of hydrazines, hydrazones, and related substrates
发明人：BUCHWALD STEPHEN L; WAGAW SEBLE; GEIS O
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:A method is provided for the transition metal-catalyzed arylation, or vinylation, of hydrazines, hydrazones, and the like. Additionally, the invention provides a conceptually novel strategy, the cornerstone of which is the transition metal-catalyzed arylation or vinylation method, for the synthesis of indoles, carbazoles, and the like. The methods and strategies of the invention may be utilized in standard, parallel, and combinatorial synthetic protocols.

专利号:EP-1058678-B1
优先权日:1998-02-26
标 题:Metal-catalyzed arylations and vinylations of hydrazines, hydrazones, hydroxylamines and oximes
发明人：BUCHWALD STEPHEN L; WAGAW SEBLE; GEIS OLIVER
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:A method is provided for the transition metal-catalyzed arylation, or vinylation, of hydrazines, hydrazones, and the like. Additionally, the invention provides a conceptually novel strategy, the cornerstone of which is the transition metal-catalyzed arylation or vinylation method, for the synthesis of indoles, carbazoles, and the like. The methods and strategies of the invention may be utilized in standard, parallel, and combinatorial synthetic protocols.