专利号:US-6399820-B2 优先权日:1998-11-04 标题:Process and reagent useful for the synthesis of sulphanilide which is perhalogenated on the carbon borne by the sulphur atom of the sulphanilide function 发明人:DESMURS JEAN-ROGER; MILLET ANDRE; PEVERE VIRGINIE 权利人:RHODIA CHIMIE SA 摘要:The present invention relates to a process and a reagent useful for the synthesis of sulphanilide which is perhalogenated on the carbon borne by the sulphur atom of the sulphanilide function. This persulphonylation process is characterized in that it comprises a step of placing a nucleophile, whose nucleophilic atom is a nitrogen, in contact with a reagent comprising, for successive or simultaneous addition, a heavy halide of sulphonyl, advantageously sulphonyl chloride, and an organic base comprising a trivalent atom from column V whose lone pair is conjugated directly or indirectly to a bond, and in that the organic part of the said sulphonyl is perhalogenated, advantageously perfluorinated, on the carbon borne by the sulphur. Application to the synthesis of intermediates for organic chemistry.
专利号:WO-2025023769-A1 优先权日:2023-07-25 标 题:Novel synthesis method of 18f-rucaparib 发明人:CHEON CHEOL-HONG; PARK JINJAE; SEO JUAN 权利人:UNIV KOREA RES & BUS FOUND 摘要:The present invention relates to a method for efficiently preparing rucaparib for a PET image. More specifically, the present invention relates to an improved preparation method for synthesizing [18F]-rucaparib in excellent yield by means of a pathway for synthesizing a pinacol boronate derivative, which is a key intermediate, by using, as a starting material, a 2-iodoaniline derivative prepared by a novel synthesis method.
专利号:US-4740604-A 优先权日:1986-05-26 标题:Benzanthrone lactones 发明人:WEIS CLAUS D; SUTTER PETER 权利人:CIBA GEIGY CORP 摘要:There are disclosed benzanthrone lactones of formula ##STR1## wherein R 1 , R 2 and R 3 are as defined in claim 1. The benzanthrone lactones of formula (1) are important intermediates for the synthesis of novel dyes which are obtained by coupling suitable diazo components to said compounds of formula (1).
专利号:US-4136033-A 优先权日:1969-11-07 标 题:6-hydroxypyridone-2 compounds having a cationic group in the 3-position 发明人:STEINEMANN WILLY 权利人:SANDOZ LTD 摘要:Compounds of the formula ##STR1## wherein K.sup.⊕ is a cationic group, preferably heterocyclic, n R is hydrogen or an organic radical, preferably alkyl, phenyl or acyl, n R 1 is hydrogen, hydrocarbyl, substituted hydrocarbyl, heterocyclyl, substituted heterocyclyl, amino or substituted amino, and n A.sup.⊖ is an anion, n Are useful as intermediates in the synthesis of azo dyes of the formula ##STR2## wherein D is an aromatic carbocyclic or heterocyclic diazo component radical, and n K.sup.⊕, r, r 1 and A.sup.⊖ are as defined above.
专利号:RU-2023713-C1 优先权日:1989-12-18 标 题:Method of synthesis of benzimidazole derivatives or their salts
专利号:US-6271419-B1 优先权日:1998-11-04 标题 :Process and reagent useful for the synthesis of sulphanilide which is perhalogenated on the carbon borne by the sulphur atom of the sulphanilide function
[参考文献]: Ya-Bin Shi, Et Al. Methyl 2-Amino-5-Chloro-Benzoate. Acta Crystallogr Sect E Struct Rep Online. 2010 Oct 31;66(Pt 11):O3025.
合成参考文献
参考文献:10.1107/s1600536811011093 摘要:Shi YB, Liu KK, Xia S, He FF, Wang HB. Methyl 4-(3-chloro-prop-oxy)benzoate. Acta Crystallogr Sect E Struct Rep Online. 2011 May 01;67(Pt 5):o1052.