CAS: 623-33-6; H-Gly-Oet.Hcl

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6436-90-4 14719-37-0 77385-90-1

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CAS号64-17-5 乙醇 | CAS号56-40-6 甘氨酸 | CAS号77385-90-1 N,N-二苄基甘氨酸乙酯 | CAS号14011-27-9 ethyl 2-chloro-... | CAS号626-35-7 硝基乙酸乙酯 | CAS号170622-26-1 5-(((-4-n-decyl... | CAS号85231-98-7 ethylN-(tert-bu... | CAS号637-81-0 叠氮乙酸乙酯 | CAS号64269-79-0 bis-(1h-imidazo... | CAS号7647-01-0 盐酸 | CAS号111915-68-5 2-(prop-2-enylc... | CAS号105172-45-0 2-[[10-[carboxy... | CAS号54509-73-8 ethene | CAS号124-38-9 二氧化碳 | CAS号74-89-5 氨基甲烷 | CAS号105172-43-8 2-[[5-[butan-2-... | CAS号39735-52-9 Ethyl 2-[(4-chl... | CAS号49755-94-4 H-甘氨酸-NHME盐酸盐 | CAS号5930-92-7 4-硝基吡咯-2-甲酸乙酯 | CAS号348-37-8 6-氟吲哚-2-甲酸乙酯

N,N-二苄基甘氨酸乙酯置于1,1,2-三氯乙烷,10% Palladium On Activated Carbon,氢气体系中,用 甲醇 作为反应溶剂,化学反应 1.0H,以99%的收率获得产物甘氨酸乙酯盐酸盐
参考文献:Highly Chemoselective Pd−c Catalytic Hydrodechlorination Leading To The Highly Efficient N-Debenzylation Of Benzylamines
标题:Highly Chemoselective Pd−c Catalytic Hydrodechlorination Leading To The Highly Efficient N-Debenzylation Of Benzylamines
摘要:In The Presence Of 1,1,2-Trichloroethane,A Novel Procedure For The Pd-C Catalytic N-Debenzylation Of Benzylamines Was Established. The Method Proceeded In A Synergistic Catalytic System And Directly Gave The Products As Crystal Amine Hydrochlorides In Practically Quantitative Yields.
DOI:10.1021/jo9007282

专利信息

专利号:US-3855198-A
优先权日:1972-09-29
标 题:Novel intermediates for synthesis of l-(5-oxoprolyl)-l-histidy-l-tryptophyl-l-seryl-l-tyrosyl-l-glycyl-l-leucyl-l-arginyl-l-prolyl-glycine amide
发明人：SARANTAKIS D
权利人:AMERICAN HOME PROD
摘要:A process for the synthesis of LRF, i.e. L-(5-oxoprolyl)-Lhistidyl-L-tryptophyl-L-seryl-L-tyrosyl-glycyl-L-leucyl -Larginyl-L-prolyl-glycine amine by the classical route is described which comprises coupling a tetrapeptide, azide terminated, representing the 3-6 amino acid sequence in LRF with a C-amide terminated tetrapeptide representing the 7-10 amino acid sequence in LRF and thereafter converting the resulting octapeptide to LRF. Novel tetrapeptides and octapeptides useful as intermediates are described.

专利号:US-11401297-B2
优先权日:2019-10-07
标题:Synthesis of glycoconjugate derivatives of a bile acid
发明人：RESTELLI ALESSANDRO; CARBONI PHILIPP; RAZZETTI GABRIELE
权利人:DIPHARMA FRANCIS SRL
摘要:Processes for the synthesis and purification of glycoconjugate derivatives of cholic acid of formula (I)are provided herein.

专利号:US-6423871-B1
优先权日:1999-02-26
标题 :Efficient synthesis of secondary amines by selective alkylation of primary amines
发明人：JUNG KYUNG WOON
权利人:UNIV SOUTH FLORIDA
摘要:A method for selective mono-N-alkylation of primary amines to produce secondary amines that are substantially free of overalkylated tertiary amines and quaternary ammonium salts, under mild reaction conditions without the necessity of protecting groups. Compounds of the class of secondary amines are produced by reacting an alkyl halide with an alkyl amine in anhydrous solvent, preferably dimethyl sulfoxide or N,N-dimethylformamide, in the presence of 0.1 to 3 molar equivalents of a cesium base. Optionally, the extent and selectivity of mono-N-alkylation is enhanced by addition to the reaction mixture of a powdered molecular sieve material for removal of water produced by the reaction, and/or tetrabutylammonium iodide to promote halide exchange. The invention permits selective and efficient mono-N-alkylation of a wide variety of substrates at 23° C.; does not cause racemization when used with enantiomerically-pure chiral substrates such as L-α-aminoesters; and is applied to solid phase synthesis whereby either the alkyl amine or alkyl halide is immobilized. The method is additionally used to produce polyamines, such as N-(2-(2-aminoethylthio)ethyl)ethylenediamine in 73% yield.

专利号:US-4965397-A
优先权日:1989-01-23
标题:Novel dibasic acid salts and their synthesis
发明人：SCHACHT ETIENNE; CROMMEN JAN
权利人:ETHYL CORP
摘要:The protecting group, Z, of protected alpha-amino acid esters of the formula n n Z--NH--CH(R.sub.2)COOCH(R)COOR.sub.1 n n is removed in the presence of a dibasic acid such as oxalic acid. This results in the formation of a new type of salt of an amino acid ester which may be represented by the formula ##STR1## In the above Q is a divalent hydrocarbyl residue of a dibasic acid, R is a hydrogen atom or hydrocarbyl group, R 1 is a hydrocarbyl group, R 2 is a hydrogen atom or hydrocarbyl group, and p is zero or one, preferably zero. When p is zero, the salts are oxalate salts. When p is one, the salts are salts of other dibasic acids. The salts (II) are useful as reactants in the synthesis of amino-acid substituted phosphazene polymers.

专利号:US-2024182642-A1
优先权日:2022-11-23
标 题:Green synthesis of amino acid based poly(ester urea)s
发明人：OLSEN BRADLEY DAVID; FRANSEN KATHARINA
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Disclosed are methods of synthesizing poly(ester urea)s.

专利号:US-2009215986-A1
优先权日:2006-03-08
标题:Solution Synthesis of Peptide Cell Growth Stimulators
发明人：EPSTEIN DAVID; KRUSZYNSKI MARIAN F; MARSH CHRISTOPHER; SCHMIDT ALBERT
权利人:EPSTEIN DAVID; KRUSZYNSKI MARIAN F; MARSH CHRISTOPHER; SCHMIDT ALBERT
摘要:A solution phase synthetic method for preparing basic tripeptides of the formula Gly-Xaa-Gly-X which have in various biological properties such as stimulating protein production when used as additives in a bioreactor. The basic tripeptides of the invention may be produced on gram or kilogram scale.