CAS: 7116-95-2; 4-Isopropyl-1,1'-Biphenyl

上下游产品

Isopropylbenzene phenyl radical 4-(propen-2-yl)biphenyl 2-biphenyl-4-yl-propan-2-ol m-mono-isopropylbiphenyl 4,4'-diphenic acid biphenyl-4-acetaldehyde 1-(1,1'-biphenyl-4-yl)-1-methylethyl hydroperoxide

联苯单乙酮置于三氯化铝体系中,用 乙醚,环己烯 作为反应溶剂,化学反应 144.0H,反应生成 4-异丙基联苯
参考文献:Efficient Synthesis And Resolution Of Trans-2-(1-Aryl-1-Methylethyl)Cyclohexanols: Practical Alternatives To 8-Phenylmenthol
标题:Efficient Synthesis And Resolution Of Trans-2-(1-Aryl-1-Methylethyl)Cyclohexanols: Practical Alternatives To 8-Phenylmenthol
摘要:A Short Synthesis And Resolution Of Effective Chiral Auxiliaries Of The 8-Arylmenthol-Type Were Achieved Using Inexpensive Materials,A Recyclable Lipase,And Easily Applied Procedures That Are Amenable To Large-Scale Preparation. A Variety Of Isopropylarenes Were Alpha-Metalated With N-Butyllithium/potassium Tert-Pentoxide And Treated With Cyclohexene Oxide To Provide Racemic Trans-2-(1-Aryl-1-Methylethyl)-Cyclohexanols 6A-F In Fair To High Yield. Candida Rugosa Lipase And Lauric Acid Were Used To Resolve These Racemic Alcohols By Converting The (-)-Enantiomer To Its Laurate Ester. The Enzymatic Resolutions Were Carried Out At 40-Degrees-C And Were Faster In Cyclohexane Than In Hexanes. The Synthesis And Resolution Of Racemic Trans-2-(1-Methyl-1-Phenylethyl)Cyclohexanol (6A) Were Performed On A 1 Mol Scale In 68% Overall Yield,Requiring Three Steps For (+)-6A And Five Steps For (-)-6A.
DOI:10.1021/jo00069A031

专利信息

专利号:US-10889599-B2
优先权日:2018-02-27
标 题:1,1-diborylalkyl-1-metal compounds, preparation method thereof, and their applications toward synthesis of 1,1-diboronate ester compounds
发明人：CHO SEUNG HWAN; LEE YEOSAN
权利人:POSTECH ACAD IND FOUND
摘要:The present invention relates to a 1,1-diborylalkyl-1-metal compound including one metal group together with two identical boron groups at the sp3 carbon center, and its use. Specifically, the present invention relates to development of novel organic reactions, synthesis of functional molecules, and synthesis of new drugs by applying the novel 1,1-diboryl-1-metal substituted alkyl compounds to various molecular libraries which could not be synthesized by conventional methodologies.

专利号:US-11999757-B2
优先权日:2017-11-01
标 题:Synthesis of boronate ester derivatives and uses thereof
发明人：BOYER SERGE HENRI; HECKER SCOTT J; VERZIJL GERARDUS K M; HERMSEN PETRUS J
权利人:MELINTA SUBSIDIARY CORP
摘要:Disclosed herein are methods for the preparation of boronate derivatives in the synthesis of antimicrobial compounds and uses thereof. Disclosed herein includes method of making a compound of Formula (B) by reducing the ketone group of the keto-ester compound of Formula (A), and the reduction can be performed using a Ruthenium based catalyst system or using an alcohol dehydrogenase bioreduction system.

专利号:US-2008125587-A1
优先权日:2006-05-25
标 题 :Synthesis of triazole compounds that modulate HSP90 activity
发明人：CHIMMANAMADA DINESH U; LEE CHI-WAN; JAMES DAVID; ZHANG SHIJIE; YING WEIWEN; CHAE JUNGHYUN; PRZEWLOKA TERESA
权利人:CHIMMANAMADA DINESH U; LEE CHI-WAN; JAMES DAVID; ZHANG SHIJIE; YING WEIWEN; CHAE JUNGHYUN; PRZEWLOKA TERESA
摘要:The present invention provides novel methods of preparing triazole compounds which inhibit the activity of Hsp90. One embodiment of the invention is directed to methods for preparing a triazole compound represented by the following Structural Formula: n n n n n n n n n n or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof, comprising the steps of: a) reacting an amide represented by the following Structural Formula: n n n n n n n n n n with a thionation reagent to form a thioamide; b) reacting the thioamide of step a) with hydrazine to form a hydrazonamide; c) reacting the hydrazonamide of step b) with a carbonylation or a thiocarbonylation reagent. n In one embodiment, the present invention is a method of synthesis of a compound of formula (IA) n n n n n n n n n n or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof, comprising reacting a compound of formula (IIA) n n n n n n n n n n with an oxidizing agent, thereby producing a compound of formula (IA). n The present invention is also directed to a method of preparing a compound or a tautomer thereof represented by the following Structural Formula: n n n n n n n n n n or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof. The method comprises the step of reacting a first starting compound represented by the following Structural Formula: n n n n n n n n n n in the presence of a mercuric salt, with a second starting compound represented by the following Structural Formula:

专利号:US-10669292-B2
优先权日:2014-05-05
标 题 :Synthesis of boronate salts and uses thereof
发明人：HECKER SCOTT; BOYER SERGE
权利人:REMPEX PHARMACEUTICALS INC
摘要:Disclosed herein are boronate intermediates in the synthesis of antimicrobial compounds and the use and preparation thereof. Some embodiments relate to crystalline boronate salt derivatives and their use in the synthesis of therapeutic compounds.

专利号:US-9315483-B2
优先权日:2007-09-13
标题 :Synthesis of deuterated catechols and benzo[D][1,3]dioxoles and derivatives thereof
发明人：JONES ANDREW D; ZELLE ROBERT E; SILVERMAN I ROBERT
权利人:CONCERT PHARMACEUTICALS INC
摘要:The present invention provides a convenient and efficient process for the synthesis of d 2 -benzo[d][1,3]dioxoles.

专利号:US-9951096-B2
优先权日:2008-08-22
标 题 :Catalysts and methods for polymer synthesis
发明人：ALLEN SCOTT D; CHERIAN ANNA E; SIMONEAU CHRIS A; FARMER JAY J; COATES GEOFFREY W; GRIDNEV ALEXEI; LAPOINTE ROBERT E
权利人:SAUDI ARAMCO TECH CO
摘要:The present invention provides unimolecular metal complexes having increased activity in the copolymerization of carbon dioxide and epoxides. Also provided are methods of using such metal complexes in the synthesis of polymers. According to one aspect, the present invention provides metal complexes comprising an activating species with co-catalytic activity tethered to a multidentate ligand that is coordinated to the active metal center of the complex.