S-Vinyl N,N-Di(N-Propyl)-Thiolcarbamate置于palladium On Activated Carbon 氢气体系中,用 甲醇 作为反应溶剂,以82%的收率获得产物茵草敌 参考文献:Process For Preparing Esters Of Thiolcarbamic Acids 标题:Process For Preparing Esters Of Thiolcarbamic Acids 摘要:本发明涉及一种制备已知的一般式(i)的硫醇氨基甲酸酯的新工艺:其中r1和r2独立地代表氢或含有1至6个碳原子的直链或支链烷基或含有2至6个原子的烯基基团,或含有1至6个碳原子的烷基或含有2至6个碳原子的烯基基团并且单独或多次被卤素,氧,硫和/或氮取代;或者r1和r2一起表示可选取代的α,ω-烷基基团,含有4至6个碳原子;r3和r4独立地代表氢或含有1至4个碳原子的烷基基团,并且可选地被卤素或含氧,硫和/或氮的基团取代;r5和r6都代表氢;或者r5和r6一起表示化学键.通式(i)的化合物通过反应制备而成:(a)通式(II)的硫醇氨基甲酸盐反应而成:其中r1和r2的含义如上所述,Y代表一价,二价或三价铵离子或碱金属离子;或(b)通式(iii)的胺反应而成:其中r1和r2的含义如上所述,同时与硫和一氧化碳反应;或(c)通式(iii)的胺与碳酰硫共同反应,与通式(iv)的炔烃反应:其中r3和r4的含义如上所述,并且如果需要,对通式(i)的得到产物进行氢化,其中r1,R2,R3和r4的含义如上所述,而r5和r6结合成化学键,形成通式(i)的化合物,其中r5和r6都代表氢.
专利号:WO-2024256370-A1 优先权日:2023-06-13 标 题 :Synthesis of glufosinate using an amidase-based process 发明人:ZIMMERMANN GUNTHER; POTT MORITZ STEFAN 权利人:BASF SE 摘要:The present invention relates to a method of preparing glufosinate, comprising the steps of hydrolysing an N-carbamoyl glufosinate amide with an Amidase enzyme to form an N- carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N- carbamoyl amino acid compound.
专利号:US-2025120400-A1 优先权日:2021-12-10 标题:Synthesis of glufosinate using a hydantoinase-based process 发明人:DITRICH KLAUS; BREUER MICHAEL; POTT MORITZ STEFAN; ZIMMERMANN GUNTHER; SEEMAYER STEFAN 权利人:BASF SE 摘要:The present invention relates to a method of manufacturing glufosinate, comprising the steps of hydrolysing a hydantoin with a Hydantoinase enzyme to form a N-carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N-carbamoyl amino acid compound.
专利号:US-11919928-B2 优先权日:2016-03-16 标题 :Method for producing dihydrotentoxin 发明人:KUBO TAKASHI; MACHIDA MASAYUKI; FUJIOKA TOMONORI; YAMAGUCHI Shigenari; KAWAI KIYOSHI 权利人:KUMIAI CHEMICAL INDUSTRY CO 摘要:An object of the present invention is to identify an enzyme having activity of synthesizing dihydrotentoxin that is a tentoxin precursor and an enzyme having activity of synthesizing tentoxin using dihydrotentoxin as a substrate. The present invention concerns a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 16 and having activity of nonribosomal peptide synthesis of dihydrotentoxin and a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 18 and having activity of converting dihydrotentoxin to tentoxin.
专利号:US-2021386068-A1 优先权日:2018-11-07 标题 :Compositions comprising pyridine carboxylate herbicides and very long chain fatty acid (vlcfa) synthesis inhibitor herbicides 发明人:KISTER JEREMY; SATCHIVI NORBERT M 权利人:CORTEVA AGRISCIENCE LLC 摘要:Disclosed herein are compositions comprising (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a VLCFA synthesis inhibitor herbicide. Also disclosed herein are methods of controlling undesirable vegetation, comprising applying to vegetation or an area adjacent the vegetation or applying in soil or water to control the emergence or growth of vegetation (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof, and (b) a VLCFA synthesis inhibitor herbicide.
专利号:US-2021352899-A1 优先权日:2018-11-07 标题 :Compositions comprising pyridine carboxylate herbicides and fatty acid and lipid synthesis inhibitor herbicides 发明人:KISTER JEREMY; SATCHIVI NORBERT M 权利人:CORTEVA AGRISCIENCE LLC 摘要:Disclosed herein are compositions comprising (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a fatty acid and lipid synthesis inhibitor (FA/LSI) herbicide, an agriculturally acceptable salt or ester thereof, or mixtures thereof. Also disclosed herein are methods of controlling undesirable vegetation, comprising applying to vegetation or an area adjacent the vegetation or applying in soil or water to control the emergence or growth of vegetation (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a fatty acid and lipid synthesis inhibitor (FA/LSI) herbicide, an agriculturally acceptable salt or ester thereof, or mixtures thereof.
专利号:ES-2717283-T3 优先权日:2012-07-24 标 题:Herbicidal compositions comprising 4-amino-3-chloro-5-fluoro-6- (4-chloro-2-fluoro-3-methoxyphenyl) pyridine-2-carboxylic acid or a derivative thereof and herbicides inhibitors of VLCFA synthesis and synthesis of fatty acids / lipids
[参考文献]: A E Smith, Et Al. Comparison Of The Persistence Of Eptc, Metribuzin, And Propanil In Saskatchewan Field Soils. Bull Environ Contam Toxicol. 1982 Aug;29(2):243-7. [参考文献]: Aqel W Abu-Qare, Et Al. Photodegradation Of The Herbicide Eptc And The Safener Dichlormid, Alone And In Combination. Chemosphere. 2002 Mar;46(8):1183-9. [参考文献]: B Bordás, Et Al. Comparative Three-Dimensional Quantitative Structure-Activity Relationship Study Of Safeners And Herbicides. J Agric Food Chem. 2000 Mar;48(3):926-31. [参考文献]: C L Stiles, Et Al. Influence Of Metam Sodium On The Dissipation And Residual Biological Activity Of The Herbicides Eptc And Pebulate In Surface Soil Under Black Plastic Mulch. J Agric Food Chem. 2000 Oct;48(10):4681-6. [参考文献]: Diána Virág, Et Al. Microbial Toxicity Of Pesticide Derivatives Produced With Uv-Photodegradation. Bull Environ Contam Toxicol. 2007 Sep;79(3):356-9.
合成参考文献
摘要:World Review of Pest Control., 9(119), 1970 摘要:Journal of Agricultural and Food Chemistry., 25(404), 1977 [] 摘要:Gigiena i Sanitariya. For English translation, see HYSAAV., 45(5)(29), 1980 摘要:Richards RP et al; Nature 327: 129-31 (1987) 摘要:USEPA/Office of Water; Federal-State Toxicology and Risk Analysis Committee (FSTRAC). Summary of State and Federal Drinking Water Standards and Guidelines (11/93) To Present