((1-环丙基乙氧基)甲基)苯置于氨,Calcium体系中,用 乙醚 作为反应溶剂,化学反应 2.0H,以96%的收率获得产物环丙基甲基甲醇 参考文献:Calcium In Liquid Ammonia For The Reduction Of Benzyl Ethers. Mechanistic Clues Derived From Chemoselectivity Studies 标题:Calcium In Liquid Ammonia For The Reduction Of Benzyl Ethers. Mechanistic Clues Derived From Chemoselectivity Studies 摘要: DOI:10.1021/jo00374A048
专利号:US-5637757-A 优先权日:1995-04-11 标 题 :One-pot synthesis of ring-brominated benzoate compounds 发明人:HILL JOHN E; FAVSTRITSKY NICOLAI A; MAMUZIC RASTKO I; BHATTACHARYA BHABATOSH 权利人:GREAT LAKES CHEMICAL CORP 摘要:A method of preparing tetrabromobenzoate compounds from tetrabromophthalic anhydride by reacting tetrabromophthalic anhydride with alcohol in the presence of a decarboxylation catalyst. The reaction may be carried out in an excess of alcohol, or with a near stoichiometric amount of alcohol by performing the reaction in an inert solvent.
专利号:US-9370515-B2 优先权日:2013-03-07 标题 :Mixed lineage kinase inhibitors and method of treatments 发明人:GOODFELLOW VAL S; NGUYEN THONG X; RAVULA SATHEESH B; GELBARD HARRIS A 权利人:CALIFIA BIO INC; UNIV ROCHESTER 摘要:Provided herein are imidazopyridine compounds having an inhibitory effect on mixed lineage kinases (MLKs), methods of their synthesis, and methods of their therapeutic. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and pharmaceutical compositions.
专利号:WO-9632368-A1 优先权日:1995-04-11 标题:One-pot synthesis of ring-brominated benzoate compounds
专利号:US-4592865-A 优先权日:1976-08-09 标 题 :Azetidinone intermediates for cephalosporin analogs 发明人:NARISADA MASAYUKI; ONOUE HIROSHI; TSUJI TERUJI; NISHITANI YASUHIRO; YOSHIOKA MITSURU; HAMASHIMA YOSHIO; NAGATA WATARU 权利人:SHIONOGI & CO 摘要:Intermediates of the following formula are useful for the synthesis of 1-oxacephalosporins. Their preparation from penicillins and the transformation process to make 1-oxacephalosporins are disclosed. The compounds are of the formula: wherein A is amino or a selected acylamino; COB is carboxy or a selected protected-carboxy; X is halogen or the group OR in which R is a group represented by following formulas: CH2CCH, CH2CCNu, CH2CHCH2, +TR wherein Nu is a selected nucleophilic group; R1 is a group of the following formula: in which Hal is halogen or alkylsulfonyloxy and R2 is alkyl or aryl; and Y is hydrogen or methoxy; with the proviso that when R is propargyl or 2-oxopropyl and R1 is A is in the 3 alpha -configuration and Y is 3 beta -hydrogen or A is in the 3 beta -configuration and Y is 3 alpha -methoxy.
专利号:EP-0825974-A1 优先权日:1995-04-11 标 题 :One-pot synthesis of ring-brominated benzoate compounds
专利号:EP-2826772-A1 优先权日:2010-01-26 标题 :Intermediates for the synthesis of oxygen-substituted 3-heteroaroylamino-propionic acid derivatives