CAS: 920509-28-0; 6-(4-Amino-2,6-Dichlorophenoxy)-4-Isopropylpyridazin-3(2H)-One

相似化合物

920509-27-9 1581304-51-9 2768217-12-3

上下游产品

N-(3,5-Dichloro-4-((5-Isopropyl-6-Oxo-1,6-Dihydropyridazin-3-yl)Oxy)Phenyl)Acetamide 1581304-51-9
N-(3,5-Dichloro-4-((5-Isopropyl-6-Oxo-1,6-Dihydropyridazin-3-yl)Oxy)Phenyl)Benzamide 1581304-52-0
3,5-Dichloro-4-((6-Chloro-5-Isopropylpyridazin-3-yl)Oxy)Aniline 920509-27-9
N-(3,5-Dichloro-4-((6-Oxo-1,6-Dihydropyridazin-3-yl)Oxy)Phenyl)Ethanamide 1581304-47-3
N-(3,5-Dichloro-4-((6-Oxo-1,6-Dihydropyridazin-3-yl)Oxy)Phenyl)Benzamide 1581304-48-4
3,5-Dichloro-4-((6-Chloropyridazin-3-yl)Oxy)Aniline 1581304-46-2

3,5-Dichloro-4-((6-Chloropyridazin-3-yl)Oxy)Aniline置于水,溶剂黄146,三氟乙酸,Lithium Chloride,Potassium Hydroxide体系中,用 四氢呋喃 作为反应溶剂,化学反应 81.91H,反应生成 6-(4-氨基-2,6-二氯苯氧基)-4-异丙基哒嗪-3(2H)-酮
参考文献: Method Of Synthesizing Thyroid Hormone Analogs And Polymorphs Thereof[fr] Procédé De Synthèse D'Analogues De L'Hormone Thyroïdienne Et De Ses Polymorphes
标题: Method Of Synthesizing Thyroid Hormone Analogs And Polymorphs Thereof[fr] Procédé De Synthèse D'Analogues De L'Hormone Thyroïdienne Et De Ses Polymorphes

专利信息

专利号:WO-2024084491-A1
优先权日:2022-10-21
标题:Process for synthesis of res metirom and its intermediates thereof
发明人：MEHTA NILESH VIPINCHANDRA
权利人:MEHTA NILESH VIPINCHANDRA
摘要:The present invention discloses a process for synthesis of Res metirom and its intermediates thereof. More particularly, the invention discloses process for synthesis of a key intermediate, 6-(4-amino, 2,6-dichlorophenoxy)4- isopropylpyridazin-3(2H)-one, of Res metirom via novel intermediate compounds of formula A. Wherein, R is selected from methyl, ethyl and propyl.

专利号:US-9968612-B2
优先权日:2012-09-17
标题:Method of synthesizing thyroid hormone analogs and polymorphs thereof
发明人：TAUB REBECCA; REYNOLDS CHARLES H
权利人:MADRIGAL PHARMACEUTICALS INC
摘要:The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TRβ mutation.