CAS: 10502-44-0; 2-Hydroxy-2-(4-Methoxyphenyl)Acetic Acid

该化合物是一种芳香化合物,其特点是存在一种甲氧基组(-OCH3)和一个附属于甲氧酸结构的碳本体酸组(-COOH),该化合物一般是白色的脱白晶状固体,由于其极极分功能组,在水和酒精等极溶剂中溶解. 甲基二氧组与其他甲酸衍生物相比,增强了其脂性,有可能影响其生物活动和相互作用. 4-甲基二氧二苯乙酸在各个领域,包括制药和有机合成业,具有潜在的药物开发用途和化学反应的中间作用.其结构特征还可能促进其再活性,使其成为对药用化学和相关学科进行进一步研究的宝贵化合物.与许多有机酸一样,它可能表现出酸性,并参与质子转移反应,从而溶解.

结构式图片

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20714-89-0 75172-66-6 184901-84-6

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ECHA物质C&L通报REACH预注册

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CAS号108-05-4 乙酸乙烯酯

合成工艺路线路线简述

    2,2,2-三氯-1-(4-甲氧基苯基)乙醇置于sodium Hydroxide体系中,用 氯仿,水 用作溶剂,化学反应 0.5H,反应生成对甲氧基苦杏仁酸
    参考文献:Decomposition Of Sodium Trichloroacetate In The Presence Of Quaternary Ammonium Under Microwave Irradiation: A Convenient One‐pot Synthesis Of α‐hydroxy Acids In Water
    标题:Decomposition Of Sodium Trichloroacetate In The Presence Of Quaternary Ammonium Under Microwave Irradiation: A Convenient One‐pot Synthesis Of α‐hydroxy Acids In Water
    摘要:
    Doi:10.1080/00397910600781091

    海关参考信息

    专利信息


    专利号:US-2004110228-A1
    优先权日:2002-04-01
    标 题:Combinatorial organic synthesis of unique biologically active compounds
    发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
    摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

    专利号:US-8138272-B2
    优先权日:2006-05-22
    标 题:Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds
    发明人:KONRADI ANDREI W; SMITH JENIFER L
    权利人:KONRADI ANDREI W; SMITH JENIFER L; ELAN PHARM INC
    摘要:This invention provides an improved synthesis of polymer conjugates of formula (I), n nof agricultural, therapeutic, and food additive compounds. In particular, a process is described for the preparation of conjugates by treating primary or secondary alcohol substituents of active compounds with polymeric nucleophiles using “Mitsunobuâ€? or related reaction conditions.

    专利号:US-7176282-B1
    优先权日:1996-09-09
    标 题 :Solid-phase peptide synthesis and agent for use in such synthesis
    发明人:HOLM ARNE; LARSEN BJARNE DUE
    权利人:ZEALAND PHARMA AS
    摘要:The present invention relates to an improved process for the production of peptides by solid-phase synthesis. The invention also relates to agents, which are useful in solid-phase peptide synthesis.

    专利号:US-7348404-B2
    优先权日:1996-09-09
    标题 :Solid-phase peptide synthesis and agent for use in such synthesis
    发明人:HOLM ARNE; LARSEN BJARNE DUE
    权利人:ZEALAND PHARMA AS
    摘要:The present invention relates to an improved process for the production of peptides by solid-phase synthesis. The invention also relates to agents which are useful in solid-phase peptide synthesis.

    专利号:CN-113355367-B
    优先权日:2018-03-22
    标题 :Application of ketoacid reductase in synthesis of chiral aromatic 2-hydroxy acid

    专利号:CN-108410831-B
    优先权日:2018-03-22
    标题:Ketoacid reductase, gene, engineering bacterium and application in synthesis of chiral aromatic 2-hydroxy acid
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    主要参考文献

    [参考文献]: Jie Zhou, Et Al. Separation Of Mandelic Acid And Its Derivatives With New Immobilized Cellulose Chiral Stationary Phase. J Zhejiang Univ Sci B. 2013 Jul;14(7):615-20.
    [参考文献]: K Valli, Et Al. Oxidation Of Monomethoxylated Aromatic Compounds By Lignin Peroxidase: Role Of Veratryl Alcohol In Lignin Biodegradation. Biochemistry. 1990 Sep 18;29(37):8535-9.
    [参考文献]: L P Candeias, Et Al. Lifetime And Reactivity Of The Veratryl Alcohol Radical Cation. Implications For Lignin Peroxidase Catalysis. J Biol Chem. 1995 Jul 14;270(28):16745-8.
    [参考文献]: M Tien, Et Al. Oxidation Of 4-Methoxymandelic Acid By Lignin Peroxidase. Mediation By Veratryl Alcohol. J Biol Chem. 1997 Apr 4;272(14):8912-7.
    [参考文献]: P J Teunissen, Et Al. 2-Chloro-1,4-Dimethoxybenzene As A Mediator Of Lignin Peroxidase Catalyzed Oxidations. Febs Lett. 1998 Nov 20;439(3):219-23.

    合成参考文献


    摘要:Parmeggiani, F.; Galman, J. L.; Montgomery, S. L.; Turner, N. J., Science of Synthesis, (2019) , 403.
    摘要:J. J. Klingenberg, J. P. Thole and R. D. Lingg, J. Chem. Eng. Data 11, 94 (1966).
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