CAS: 162101-31-7; 2-Fluoro-4-Methoxyphenylboronic Acid

相似化合物

628692-21-7 406482-20-0 279261-82-4

上下游产品

Trimethyl borate 1-bromo-2-fluoro-4-methoxybenzene water 6-(2-fluoro-4-hydroxyphenyl)-1-naphthol 3,4-bis(2-fluoro-4-methoxyphenyl)furan 2,5-bis(2-fluoro-4-methoxyphenyl)thiophene 2,5-bis(2-fluoro-4-hydroxyphenyl)furan

硼酸三甲酯,4-溴-3-氟苯甲醚置于正丁基锂体系中,用 四氢呋喃 用作溶剂,以43%的收率获得2-氟-4-甲氧基苯硼酸
参考文献:快速紧密的硼酸盐形成,实现点击生物正交共轭
标题:快速紧密的硼酸盐形成,实现点击生物正交共轭
摘要:新的点击生物正交反应系统设计成使快速连接(ķ On ~340 米-1 小号-1)一个刚性的环状二醇(nopoldiol)和仔细优化硼酸伙伴的缀合衍生物,2-甲基-5-羧甲基苯基硼酸.使用NMR和荧光光谱研究,发现对应于硼酸酯在水中低微摩尔浓度分钟内可逆地形成,从而提供亚微摩尔的平衡常数(ķ当量~10 5-10 6 米-1).用模型蛋白硫氧还蛋白和白蛋白证明了在生理条件下的有效蛋白结合,并通过质谱和凝胶电泳进行了表征.
Doi:10.1002/anie.201510321

专利信息

专利号:WO-2015088565-A1
优先权日:2013-12-13
标题:P2x4 receptor modulating compounds and methods of use thereof
发明人：NEWCOM JASON S; SPEAR KERRY L
权利人:SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are P2X4 receptor modulating compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including but not limited to, chronic pain, neuropathy, inflammatory diseases and central nervous system disorders.

专利号:US-9951062-B2
优先权日:2012-12-14
标 题 :Substituted 1 H-pyrrolo [2, 3-b] pyridine and 1 H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors
发明人：VANKAYALAPATI HARIPRASAD; YERRAMREDDY VENKATAKRISHNAREDDY; GANIPISETTY VENU BABU; TALLURI SURESHKUMAR; APPALANENI RAJENDRA P
权利人:ARRIEN PHARMACEUTICALS LLC
摘要:Compounds according to Formulas I, IA or IB: n nto pharmaceutically acceptable composition, salts thereof, their synthesis and their use as SIK2 inhibitors including such compounds and methods of using said compounds in the treatment of various diseases and/or disorders such as cancer, stroke, cardiovascular, obesity and type II diabetes.