CAS: 188582-62-9; 4-Bromo-2-Fluorobenzyl Alcohol

上下游产品

CAS号57848-46-1 4-溴-2-氟苯甲醛 | CAS号112704-79-7 4-溴-2-氟苯甲酸 | CAS号179232-29-2 4-溴-2-氟苯甲酸甲酯 | CAS号219873-06-0 4-氰基-2-氟苄醇

2-氟-4-溴苯甲酸甲酯置于甲醇,Sodium Tetrahydroborate体系中,化学反应 16.5H,以25 G的收率获得4-溴-2-氟苄醇
参考文献: Compound,Aldehyde Dehydrogenase 2 Activator,Pharmaceutical Composition,And Treatment And/or Preventative Drug[fr] Composé,Activateur De L'Aldéhyde Déshydrogénase 2,Composition Pharmaceutique,Et Médicament De Traitement Et/ou De Prévention[ja] 化合物,アルデヒドデヒドロゲナーゼ2活性化剤,医薬組成物,並びに治療及び／又は予防薬
标题: Compound,Aldehyde Dehydrogenase 2 Activator,Pharmaceutical Composition,And Treatment And/or Preventative Drug[fr] Composé,Activateur De L'Aldéhyde Déshydrogénase 2,Composition Pharmaceutique,Et Médicament De Traitement Et/ou De Prévention[ja] 化合物,アルデヒドデヒドロゲナーゼ2活性化剤,医薬組成物,並びに治療及び／又は予防薬
摘要:アルデヒドデヒドロゲナーゼ2(aldh2)活性化作用を有する化合物等を提供すること. 下記式(1)[式中,aは,複素環であり,r1及びr2は,それぞれ独立して,水素,アルキル,アルケニル,又はアルキニルであり,r3は,アルキル,アルケニル,又はアルキニルであり,x1及びx2は,それぞれ独立して,ハロゲンである] で表される化合物,その医薬上許容可能な塩又はそれらのプロドラッグ.

专利信息

专利号:US-9073935-B2
优先权日:2011-11-11
标 题:Substituted benzylspiroindolin-2-one analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M1
发明人：LINDSLEY CRAIG W; CONN P JEFFREY; WOOD MICHAEL R; HOPKINS COREY R; MELANCON BRUCE J; POSLUSNEY MICHAEL S
权利人:UNIV VANDERBILT
摘要:In one aspect, the invention relates to substituted benzylspiroindolin-2-one analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M 1 (mAChR M 1 ); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-8692026-B2
优先权日:2010-07-15
标题:Processes for producing 4-bromo-2-methoxybenzaldehyde
发明人：GIARD THIERRY J; MUTTERER VINCENT L; DURVAUX CHRISTOPHE
权利人:GIARD THIERRY J; MUTTERER VINCENT L; DURVAUX CHRISTOPHE; ALBEMARLE CORP
摘要:A new synthesis of 4-bromo-2-methoxybenzaldehyde is reported from 1,4 dibromo 2-fluorobenzene. First, 2-fluoro-4-bromobenzaldehyde is prepared through metal halogen exchange and formylation with a formyl source at 0° C. After crystallization, this intermediate is reacted with methanol in the presence of potassium carbonate. Subsequently, 4-bromo-2-methoxy-benzaldehyde is crystallized.

专利号:US-9012445-B2
优先权日:2012-01-12
标题 :Substituted 4-(1H-pyrazol-4-yl)benzyl analogues as positive allosteric modulators of mAChR M1 receptors
发明人：LINDSLEY CRAIG W; CONN P JEFFREY; WOOD MICHAEL R; MELANCON BRUCE J; POSLUSNEY MICHAEL S; TARR JAMES C
权利人:UNIV VANDERBILT
摘要:In one aspect, the invention relates to substituted 4-(1H-pyrazol-4-yl)benzyl analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M 1 (mAChR M 1 ); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-9029563-B2
优先权日:2012-01-06
标题:Substituted 1-benzylindolin-2-one analogs as positive allosteric modulators of muscarinic acetylcholine M1 receptors
发明人：LINDSLEY CRAIG W; CONN P JEFFREY; WOOD MICHAEL R; MELANCON BRUCE J; POSLUSNEY MICHAEL S
权利人:UNIV VANDERBILT
摘要:In one aspect, the invention relates to substituted 1-benzylindolin-2-one analog compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M 1 (mAChR M 1 ); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-9586964-B2
优先权日:2011-10-28
标 题:Substituted 2-(4-heterocyclylbenzyl)isoindolin-1-one analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M1
发明人：LINDSLEY CRAIG W; CONN P JEFFREY; WOOD MICHAEL R; HOPKINS COREY R; MELANCON BRUCE J; POSLUSNEY MICHAEL S; ENGERS DARREN W
权利人:UNIV VANDERBILT
摘要:In one aspect, the invention relates to substituted 2-(4-heterocyclylbenzyl)isoindolin-1-one analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M 1 (mAChR M 1 ); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-7825149-B2
优先权日:2006-01-19
标 题 :Substituted imidazoles
发明人：CHUBB NATHAN ANTHONY LOGAN; COX MARK ROGER; DAUVERGNE JEROME SEBASTIEN; EWIN RICHARD ANDREW; LAURET CHRISTELLE
权利人:PFIZER LTD
摘要:This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides.