1-羟基-2-萘甲酸置于sodium Hydroxide,Dipotassium Peroxodisulfate体系中,化学反应生成1,4-二羟基-2-萘甲酸 参考文献:Desai; Sethna,Journal Of The Indian Chemical Society,1951,Vol. 28,P. 213,216 标题:Desai; Sethna,Journal Of The Indian Chemical Society,1951,Vol. 28,P. 213,216
专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:US-11643660-B2 优先权日:2016-11-28 标题:Nucleoside derivative or salt thereof, polynucleotide synthesis reagent, method for producing polynucleotide, polynucleotide, and method for producing binding nucleic acid molecule 发明人:MINAGAWA HIROTAKA; HORII KATSUNORI; AKITOMI JOU; KANEKO NAOTO; WAGA IWAO; KUWAHARA MASAYASU 权利人:NEC SOLUTION INNOVATORS LTD; UNIV GUNMA NAT UNIV CORP 摘要:The present invention provides a novel nucleoside derivative or a salt thereof, a polynucleotide synthesis reagent, a method for producing a polynucleotide, a polynucleotide, and a method for producing a binding nucleic acid molecule. The nucleoside derivative or a salt thereof of the present invention is represented by the following chemical formula (1).In the chemical formula (1), Su is an atomic group having a sugar skeleton at a nucleoside residue or an atomic group having a sugar phosphate skeleton at a nucleotide residue, and may or may not have a protecting group, L1 and L2 are each independently a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms, X1 is an imino group (—NR1—), an ether group (—O—), or a thioether group (—S—), and R1 is a hydrogen atom or a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms.
专利号:US-10611791-B2 优先权日:2016-09-15 标题:Nucleoside derivative or salt thereof, polynucleotide synthesis reagent, method for producing polynucleotide, polynucleotide, and method for producing binding nucleic acid molecule 发明人:MINAGAWA HIROTAKA; HORII KATSUNORI; AKITOMI JOU; KANEKO NAOTO; WAGA IWAO; KUWAHARA MASAYASU 权利人:NEC SOLUTION INNOVATORS LTD; UNIV GUNMA NAT UNIV CORP 摘要:The present invention provides a novel nucleoside derivative or a salt thereof, a polynucleotide synthesis reagent, a method for producing a polynucleotide, a polynucleotide, and a method for producing a binding nucleic acid molecule. n The nucleoside derivative or a salt thereof of the present invention is represented by the following chemical formula (1): n nwhere in the chemical formula (1), Su is an atomic group having a sugar skeleton at a nucleoside residue or an atomic group having a sugar phosphate skeleton at a nucleotide residue, and may or may not have a protecting group, L 1 and L 2 are each independently a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms, X 1 and X 2 are each independently an imino group (—NR 1 —), an ether group (—O—), or a thioether group (—S—), and the R 1 is a hydrogen atom or a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms.
专利号:US-9217012-B2 优先权日:2009-04-08 标题 :Inhibitors of protein tyrosine phosphatases 发明人:ZHANG ZHONG-YIN; ZHANG SHENG 权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP 摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.
专利号:CN-111560383-A 优先权日:2020-03-14 标 题 :Recombinant bacteria for promoting the synthesis of menaquinone-7 by Bacillus subtilis and its genetic modification method
专利号:CN-116732081-B 优先权日:2023-08-07 标题 :A method for improving the synthesis of menadione by Bacillus subtilis, obtaining a recombinant strain and its application
参考文献:10.1263/jbb.101.464 摘要:Furuichi K, Hojo K, Katakura Y, Ninomiya K, Shioya S. Aerobic culture of Propionibacterium freudenreichii ET-3 can increase production ratio of 1,4-dihydroxy-2-naphthoic acid to menaquinone. Journal of Bioscience and Bioengineering. 2006 Jun;101(6):464–70. doi: 10.1263/jbb.101.464.